Trillium Therapeutics Inc. — Proxy Solicitation & Information Statement 2021

Apr 30, 2021

==> picture [36 x 239] intentionally omitted <==

Mr A Sample Designation (if any) Add1 Add2 add3 add4 add5 add6

000001

==> picture [97 x 18] intentionally omitted <==

8th Floor, 100 University Avenue Toronto, Ontario M5J 2Y1 www.computershare.com

Security Class COMMON SHARES Holder Account Number C1234567890 XXX

Fold

Form of Proxy - Annual General and Special Meeting to be held on June 8, 2021

This Form of Proxy is solicited by and on behalf of Management.

Notes to proxy

1. Every holder has the right to appoint some other person or company of their choice, who need not be a holder, to attend and act on their behalf at the meeting or any adjournment or postponement thereof. If you wish to appoint a person or company other than the Management Nominees whose names are printed herein, please insert the name of your chosen proxyholder in the space provided (see reverse).

2. If the securities are registered in the name of more than one owner (for example, joint ownership, trustees, executors, etc.), then all those registered should sign this proxy. If you are voting on behalf of a corporation or another individual you may be required to provide documentation evidencing your power to sign this proxy with signing capacity stated.

3. This proxy should be signed in the exact manner as the name(s) appear(s) on the proxy.

4. If a date is not inserted in the space provided on the reverse of this proxy, it will be deemed to bear the date on which it was mailed to the holder by Management.

5. The securities represented by this proxy will be voted as directed by the holder, however, if such a direction is not made in respect of any matter, and the proxy appoints the Management Nominees listed on the reverse, this proxy will be voted as recommended by Management.

1. The securities represented by this proxy will be voted in favour, or withheld from voting, or voted against each of the matters described herein, as applicable, in accordance with the instructions of the holder, on any ballot that may be called for. If you have specified a choice with respect to any matter to be acted on, the securities will be voted accordingly.

2. This proxy confers discretionary authority in respect of amendments or variations to matters identified in the Notice of Meeting and Management Information Circular or other matters that may properly come before the meeting or any adjournment or postponement thereof, unless prohibited by law.

3. This proxy should be read in conjunction with the accompanying documentation provided by Management.

Fold

Proxies submitted must be received by 1:00 pm (Toronto time) on June 4, 2021.

VOTE USING THE TELEPHONE OR INTERNET 24 HOURS A DAY 7 DAYS A WEEK!

• To Receive Documents To Virtually Attend

• To Vote Using the Telephone To Vote Using the Internet Electronically the Meeti ~~n~~ g

• • Call the number listed BELOW from a touch • Go to the following web • You can enroll to receive future securityholder • You can attend the meeting virtually by tone telephone. site: www.investorvote.com communications electronically by visiting visiting the URL provided on the back of

• 1-866-732-VOTE (8683) Toll Free • Scan the QR code Smartphone? www.investorcentre.com. this proxy. to vote now.

If you vote by telephone or the Internet, DO NOT mail back this proxy.

Voting by mail may be the only method for securities held in the name of a corporation or securities being voted on behalf of another individual. Voting by mail or by Internet are the only methods by which a holder may appoint a person as proxyholder other than the Management Nominees named on the reverse of this proxy. Instead of mailing this proxy, you may choose one of the two voting methods outlined above to vote this proxy.

To vote by telephone or the Internet, you will need to provide your CONTROL NUMBER listed below.

CONTROL NUMBER 123456789012345

CPUQC01.E.INT/000001/i1234

01QFNA

C1234567890

MR SAM SAMPLE

XXX 123

==> picture [155 x 34] intentionally omitted <==

Appointment of Proxyholder

I/We being holder(s) of securities of Trillium Therapeutics Inc.

(the “Corporation”) hereby appoint: Mr. Paul Walker, or failing this person, Dr. Jan Skvarka, or failing this person, Mr. James Parsons (the “Management Nominees”)

Print the name of the person you are OR appointing if this person is someone other than the Management Nominees listed herein.

Note: If completing the appointment box above YOU MUST go to http://www.computershare.com/Trillium and provide Computershare with the name and email address of the person you are appointing. Computershare will use this information ONLY to provide the appointee with a user name to gain entry to the online meeting.

as my/our proxyholder with full power of substitution and to attend, act and to vote for and on behalf of the holder in accordance with the following direction (or if no directions have been given, as the proxyholder sees fit) and on all other matters that may properly come before the Annual General and Special Meeting of shareholders of the Corporation to be held online at https://web. lumiagm.com/268053638 on June 8, 2021 at 1:00 pm (Toronto time) and at any adjournment or postponement thereof.

VOTING RECOMMENDATIONS ARE INDICATED BY HIGHLIGHTED TEXT OVER THE BOXES.

1. Election of Directors

1. Election of Directors	1. Election of Directors
For Withhold		For	Withhold					For	Withhold
01. Mr. Luke Beshar	02. Dr. Michael Kamarck				03. Mr. Paul Walker						Fold
04. Mr. Paolo Pucci	05. Dr. Jan Skvarka				06. Dr. Helen Tayton-Martin
07. Mr. Scott Myers
								For	Withhold
2. Appointment of Auditors
To reappoint Ernst & Young, LLP, Chartered Professional Accountants, Licensed Public Accountants, as auditors of the Corporation for the ensuing year and to authorize the directors to fx the remuneration to be paid to the auditors.
								For	Against
3. Advisory vote on the compensation of the Corporation’s named executive offcers
To consider and if deemed appropriate, act upon an advisory vote on the compensation of the Corporation’s		named executive offcers, the full text of the resolution is
set forth in the management information circular and proxy	statement (the “Circular”) prepared in connection	with the Meeting.
						1 Year	2	Years		3 Years

4. Advisory vote on the frequency of future advisory votes on the compensation of the Corporation’s named executive officers

To consider and if deemed appropriate, act upon an advisory vote on the frequency of future advisory votes on the compensation of the Corporation’s named executed officers, the full text of the resolution is set forth in the Circular.

Fold

Signature(s) Date If no voting instructions are MM / DD / YY Annual Financial Statements – would like to receive the Annual Financial Statements and Mark this box if you Mark this box if you Information Circular – Mark this box if you would like to receive the Information Circular by mail for the next accompanying Management’s Discussion and Analysis securityholders’ meeting. by mail.

Signature of Proxyholder

I/We authorize you to act in accordance with my/our instructions set out above. I/We hereby revoke any proxy previously given with respect to the Meeting. If no voting instructions are indicated above, and the proxy appoints the Management Nominees, this Proxy will be voted as recommended by Management.

Interim Financial Statements would like to receive interim financial statements and – Mark this box if you Annual Financial Statements – would like to receive the Annual Financial Statements and Mark this box if you Mark this box if you accompanying Management’s Discussion and Analysis accompanying Management’s Discussion and Analysis by mail. by mail. If you are not mailing back your proxy, you may register online to receive the above financial report(s) by mail at www.computershare.com/mailinglist.

S H C Q

A R 1

X X X X

3 1 4 7 7 4

999999999999

01QFOA