TG THERAPEUTICS, INC. — Director's Dealing 2008

Mar 28, 2008

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: MANHATTAN PHARMACEUTICALS INC (MHAN)
CIK: 0001001316
Period of Report: 2008-03-25

Reporting Person: WEISER MICHAEL (Director)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2008-03-25	Stock Options	$0.17	A	75000	Acquired	2018-03-25	Common Stock (75000)	Direct

Holdings (Derivative)

Security	Exercise Price	Expiration	Underlying	Shares	Ownership
Warrant	$1.21	2009-01-27	Common Stock (103655)	103655	Direct
Stock Options	$1.65	2014-01-27	Common Stock (75000)	75000	Direct
Warrant	$1.44	2010-08-30	Common Stock (24099)	24099	Direct
Stock Options	$1.00	2015-01-11	Common Stock (30000)	30000	Direct
Stock Options	$0.71	2017-01-30	Common Stock (50000)	50000	Direct

Footnotes

F1: 75,000 shares have vested.

F2: Immediately

F3: 10,000 shares vest on each of 1/11/05, 1/11/06, and 1/11/07.

F4: 16,667 shares vest on each of 1/30/07 and 1/30/08; 16,666 shares vest on 1/30/09.

F5: 41,667 shares vest on the grant date, 3/25/08, an additional 16,667 shares vest on 3/25/09 and an additional 16,666 shares
vest on 3/25/10.