Tempus AI, Inc. — Director's Dealing 2025

Nov 21, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Tempus AI, Inc. (TEM)
CIK: 0001717115
Period of Report: 2025-11-18

Reporting Person: LEFKOFSKY ERIC P (N/A)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-11-18	Class A Common Stock	S	11567	$65.26	Disposed	2008475	Direct
2025-11-18	Class A Common Stock	S	5262	$66.15	Disposed	2003213	Direct
2025-11-20	Class A Common Stock	S	6221	$65.59	Disposed	9068312	Indirect
2025-11-20	Class A Common Stock	S	6467	$66.33	Disposed	9061845	Indirect
2025-11-20	Class A Common Stock	S	1913	$67.39	Disposed	9059932	Indirect
2025-11-20	Class A Common Stock	S	910	$68.38	Disposed	9059022	Indirect
2025-11-20	Class A Common Stock	S	2041	$69.43	Disposed	9056981	Indirect
2025-11-20	Class A Common Stock	S	3074	$70.58	Disposed	9053907	Indirect
2025-11-20	Class A Common Stock	S	8841	$71.63	Disposed	9045066	Indirect
2025-11-20	Class A Common Stock	S	3783	$72.20	Disposed	9041283	Indirect
2025-11-20	Class A Common Stock	S	24881	$65.59	Disposed	16812588	Indirect
2025-11-20	Class A Common Stock	S	25866	$66.33	Disposed	16786722	Indirect
2025-11-20	Class A Common Stock	S	7660	$67.39	Disposed	16779062	Indirect
2025-11-20	Class A Common Stock	S	3640	$68.38	Disposed	16775422	Indirect
2025-11-20	Class A Common Stock	S	8158	$69.43	Disposed	16767264	Indirect
2025-11-20	Class A Common Stock	S	12295	$70.58	Disposed	16754969	Indirect
2025-11-20	Class A Common Stock	S	35362	$71.63	Disposed	16719607	Indirect
2025-11-20	Class A Common Stock	S	15138	$72.20	Disposed	16704469	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Class A Common Stock	406	Indirect
Class A Common Stock	10000000	Indirect
Class A Common Stock	206	Indirect
Class A Common Stock	832131	Indirect

Footnotes

F1: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of minimum statutory tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary sale by the Reporting Person.

F2: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.7216 to $65.685 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (5), (7), (8), (9), (10), (11), (12) and (13).

F3: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.78 to $66.62 inclusive.

F4: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 4, 2025.

F5: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.94 to $65.935 inclusive.

F6: The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC and (iii) a trustee of Lefkofsky Family Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT.

F7: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.94 to $66.935 inclusive.

F8: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.94 to $67.93 inclusive.

F9: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.94 to $68.835 inclusive.

F10: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.00 to $69.90 inclusive.

F11: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.05 to $71.04 inclusive.

F12: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.065 to $72.06 inclusive.

F13: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.065 to $72.40 inclusive.

F14: Represents the number of shares owned after Blue Media, LLC contributed a portion of its shares to the Lefkofsky Family Foundation.