Tempus AI, Inc. — Director's Dealing 2025

Dec 22, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Tempus AI, Inc. (TEM)
CIK: 0001717115
Period of Report: 2025-12-18

Reporting Person: LEFKOFSKY ERIC P (N/A)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-12-18	Class A Common Stock	S	3571	$62.26	Disposed	9004462	Indirect
2025-12-18	Class A Common Stock	S	5118	$63.08	Disposed	8999344	Indirect
2025-12-18	Class A Common Stock	S	18960	$64.12	Disposed	8980384	Indirect
2025-12-18	Class A Common Stock	S	2800	$64.92	Disposed	8977584	Indirect
2025-12-18	Class A Common Stock	S	2801	$66.04	Disposed	8974783	Indirect
2025-12-18	Class A Common Stock	S	14153	$62.26	Disposed	16307316	Indirect
2025-12-18	Class A Common Stock	S	20489	$63.08	Disposed	16286827	Indirect
2025-12-18	Class A Common Stock	S	75913	$64.12	Disposed	16210914	Indirect
2025-12-18	Class A Common Stock	S	11238	$64.92	Disposed	16199676	Indirect
2025-12-18	Class A Common Stock	S	11207	$66.04	Disposed	16188469	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Class A Common Stock	2003213	Direct
Class A Common Stock	406	Indirect
Class A Common Stock	10000000	Indirect
Class A Common Stock	206	Indirect
Class A Common Stock	832131	Indirect
Class A Common Stock	250000	Indirect

Footnotes

F1: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 4, 2025.

F2: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.59 to $62.5897 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2), (4), (5), (6) and (7).

F3: The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC, (iii) a trustee of each of Lefkofsky Family Foundation and Vas.org Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT.

F4: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.59 to $63.5897 inclusive.

F5: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.59 to $64.5898 inclusive.

F6: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.59 to $65.5649 inclusive.

F7: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.59 to $66.50 inclusive.

F8: Represents the number of shares owned after Blue Media, LLC contributed a portion of its shares to the Vas.org.