Telix Pharmaceuticals Ltd — Capital/Financing Update 2021

Jun 6, 2021

Telix Pharmaceuticals Limited ACN 616 620 369 Suite 401, 55 Flemington Road North Melbourne Victoria, 3051 Australia

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Telix and ATS Awarded $1.56M ‘Eurostars’ Grant for Alpha Therapy

Liège (Belgium) and Gothenburg (Sweden) – 7 June 2021 . Advanced Nuclear Medicine Ingredients S.A. (‘ANMI’), a wholly owned European subsidiary of Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company), and Swedish radiopharmaceutical production company Alpha Therapy Solutions (‘ATS’), today announce that they have been jointly awarded a €990K (A$1.56M) ‘Eurostars-2’ research grant from the EUREKA Association.

The Eurostars program[1] supports international innovative projects involving at least two different participants from different Eurostars countries and led by R&D-performing small and medium-sized enterprises. Eurostars projects are awarded access to public funding, which originates from participating countries’ national budgets and the European Union Horizon 2020 framework.

Funding has been awarded to Telix and ATS to develop a novel anti-cancer Targeted Alpha Therapy (TAT) using the alpha-particle emitting radioisotope; astatine-211. The scope of the project, with a budget of €990K over three years, comprises scale up radiochemistry, preclinical studies and support for a clinical proof-of-concept study. The efficient scale-up production of astatinated radiopharmaceuticals is made possible through the use of ATS’ novel automated astatine production platform.

ATS Co-Founder and Chief Executive Officer, Milton Lönnroth said, “We are honoured and excited to enter this collaboration with Telix Pharmaceuticals. We look forward to helping to bring this project into clinical development and to validating our platform for the clinical production of astatinated radiopharmaceuticals. Astatine-211 presents some highly favourable characteristics for use in Targeted Alpha Therapy. However, the challenges of producing clinical-scale quantities of this shortlived radioisotope, combined with the lack of commercially available equipment for automated production have so far limited more widespread development. Our platform aims to mitigate these perceived challenges by making the isotope purification and radiopharmaceutical production steps, safer, more reliable and more efficient.”

Telix Chief Scientist, Dr Michael Wheatcroft added, “Coupling the tumour-targeting specificity of peptides and antibodies with the cell-killing power of alpha-emitting radioisotopes offers potential in creating more effective therapeutics in certain cancers. The combination of Telix’s targeting agents and ATS’ automated production platform forms a potent fusion of capability to demonstrate the potential utility of Astatine-based Targeted Alpha Therapies. We are grateful to the Eurostars program in helping our two companies explore the synergies of our combined technologies, expertise and resources to enable the development of this promising area of oncology research.”

About Alpha Therapy Solutions

ATS aims to become the leading global partner for production of radiopharmaceuticals based on the alpha-particle emitting isotope astatine-211. ATS is developing the world’s first automated production platform for astatinated radiopharmaceuticals; a product which will greatly enhance clinical research in this field and which is essential for drug commercialisation. ATS also provides industry-leading know-how related to astatine radiochemistry and the production of astatine-based radiopharmaceuticals. For more information visit www.alphatherapysolutions.com, and follow ATS on LinkedIn.

1 See: http://www.eurostars-eureka.eu/

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About Telix Pharmaceuticals Limited

Telix is a clinical-stage biopharmaceutical company focused on the development of diagnostic and therapeutic products using Molecularly Targeted Radiation (MTR). Telix is headquartered in Melbourne, Australia with international operations in Belgium, Japan, and the United States. Telix is developing a portfolio of clinical-stage products that address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX). For more information visit www.telixpharma.com and follow Telix on Twitter (@TelixPharma) and LinkedIn.

Telix’s lead investigational product, Illuccix[®] (TLX591-CDx) for prostate cancer imaging, has been accepted for filing by the U.S. FDA,[2] and is under priority evaluation by the Australian Therapeutic Goods Administration (TGA).[3] Telix is also progressing marketing authorisation applications for Illuccix[®] in the European Union[4] and Canada.[5] None of Telix’s products have received a marketing authorisation in any jurisdiction.

Telix Corporate Contact

Dr. Christian Behrenbruch Telix Pharmaceuticals Limited Managing Director and CEO Email: chris.behrenbruch@telixpharma.com

Telix Corporate Communications

Dr. Stewart Holmstrom Telix Pharmaceuticals Limited Director of Corporate Communications Email: stewart.holmstrom@telixpharma.com

Important Information

This announcement does not constitute an offer to sell, or a solicitation of an offer to buy, securities in the United States, or in any other jurisdiction in which such an offer would be illegal. The securities referred to herein have not been and will not be registered under the United States Securities Act of 1933 (the “U.S. Securities Act”), or under the securities laws of any state or other jurisdiction of the United States and may not be offered or sold within the United States, unless the securities have been registered under the U.S. Securities Act or an exemption from the registration requirements of the U.S. Securities Act is available. None of the technologies or products described in this document have received a marketing authorisation in any jurisdiction. This announcement has been authorised for release by Dr Christian Behrenbruch, Managing Director and Chief Executive Officer.

2 ASX disclosure 24/11/20.

3 ASX disclosure 14/04/21.

4 ASX disclosure 1/05/20.

5 ASX disclosure 16/12/20.

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