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Circio Holding ASA

Report Publication Announcement Aug 21, 2025

3769_rns_2025-08-21_2a60f1d5-2596-47c5-9d30-0fb502334554.html

Report Publication Announcement

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Circio invites to first half 2025 report and R&D update webcast on 28 August

Circio invites to first half 2025 report and R&D update webcast on 28 August

* CEO Dr. Erik D Wiklund and CFO Dr. Lubor Gaal will provide a general

corporate update and present the first half 2025 financial results

* CTO Dr. Thomas B Hansen will present recent in vivo data demonstrating

further enhancements of Circio s circVec AAV gene therapy technology

Oslo, Norway 21 August 2025 -- Circio Holding ASA (OSE: CRNA), a biotechnology

company developing powerful circular RNA technology for next generation

nucleic acid medicine, invites to a live webcast at 10:00am CEST on Thursday

28 August 2025. In the webcast, Circio management will provide a corporate

update, including the first half 2025 financial results, and present recent in

vivo data for its circVec platform technology.

The webcast will include an overview of ongoing testing and optimization of

circVec generation 3 for AAV gene therapy, including strong performance in new

in vivo settings, as well as an outlook on experimental plans and milestones.

The corporate section will cover Circio s first half 2025 financial results

(unaudited) and provide an update on financing and business development

activities in the second half of 2025.

Presenters:

CEO Dr. Erik Digman Wiklund

CFO Dr. Lubor Gaal

CTO Dr. Thomas Birkballe Hansen

Time: 10:00 CEST on 28 August 2025

click here to access the Teams webcast

(https://teams.microsoft.com/l/meetup-join/19%3ameeting_M2I2MGFjYTgtYWZjMC00YTkwLWJiZGQtNzk5ZWM0MTc2ODIy%40thread.v2/0?context={"Tid"%3a"66b0661a-3ec3-48a8-a966-5b0cce82b3fe"%2c"Oid"%3a"3f5f84b0-5521-4c04-bd8a-e185546abe04"})

Meeting ID: 352 997 264 281

Passcode: dj23Wc6o

Participate by phone:

+47 21402155

Phone conference ID: 591397143#

Questions can be submitted in advance by email to Erik D Wiklund:

[email protected] or directly in the live webcast

A recording of the webcast will be made available on the Circio webpage

(http://www.circio.com/)

For further information, please contact:

Erik Digman Wiklund, CEO

Phone: +47 413 33 536

Email: [email protected]

Lubor Gaal, CFO

Phone: +34 683 34 3811

Email: [email protected]

About Circio

Building circular RNA expression systems for enhanced gene and cell therapies

Circio Holding ASA is a biotechnology company developing powerful circular RNA

vector expression technology for next generation nucleic acid medicine.

Circio has established a unique circular RNA (circRNA) vector expression

technology for next generation RNA, DNA and viral therapeutics. The

proprietary circVec platform is based on a modular genetic cassette design for

efficient biogenesis of multifunctional circRNA inside cells. The circVec

platform has applications in multiple therapeutic settings, including genetic

medicine, cell therapy and chronic disease. It has demonstrated over 70-fold

prolonged RNA half-life and up to 15-fold enhanced protein expression vs.

conventional mRNA vector systems in vivo, and has the potential to become a

new gold-standard protein expression technology. The circRNA R&D activities

are being conducted by the wholly owned subsidiary Circio AB in Stockholm,

Sweden.

In parallel, Circio is continuing to develop its legacy immuno-oncology

program, TG01, through cost-efficient external academic and industry

collaborations. TG01 targets RAS-mutated cancers and is being tested in two

clinical trials in Norway and the USA. TG01 is a therapeutic peptide vaccine

adjuvanted by STIMULON QS-21 licensed from Agenus Inc.

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