SYNTARA LIMITED — Major Shareholding Notification 2017

Apr 3, 2017

			Form 604Corporations Act 2001Section 671B
			Notice of change of interests of substantial holder
To Company Name/SchemePharmaxis Ltd
ACN/ARSN		082 811 630
1. Details of substantial holder (1)
Name						BVF Partners LP on its own behalf and on behalf of BVF Inc., Mark N. Lampert and Biotechnology Value Fund, L.P. and
ACN/ARSN (if applicable)		Biotechnology Value Fund II, L.P.
There was a change in the interests of thesubstantial holder on:
			06/10/2015 to 31/03/2017 (both dates inclusive)
The previous notice was given to the company on			10/09/2015
The previous notice was dated			09/09/2015
2.Previous and present voting powerrelevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:						The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a
	Class of securities (4)		Previous notice		Present notice
rows)		Fully Paid Ordinary Shares (note: this rowrelates only to BVF Partners LP, BVF Inc.,and Mark N. Lampert, and includes thevotes and voting power in the next two	Person's votes41,209,253	Voting power (5)12.99%	Person's votes60,423,669	Voting power (5)18.94%
		Fully Paid Ordinary Shares (note: this rowrelates only to Biotechnology Value Fund.L.P. in respect of its registered holdings)	20,084,414	6.33%	27,649,910	8.66%
		Fully Paid Ordinary Shares (note: this rowrelates only to Biotechnology Value Fund II,L.P. in respect of its registered holdings)			18,097,097	5.67%
3.Changes in relevant interests
Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or
scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:
Date ofchange		Person whoserelevant interestchanged	Nature ofchange (6)	Considerationgiven in relationto change (7)	Class andnumber ofsecuritiesaffected	Person's votesaffected
06/10/2015		BVF Partners, L.P., BVFInc. and Mark N. Lampert,BVF Partners OS, Ltd.,and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$920.00	4,000 fully paid
		BVF Partners, L.P., BVFInc. and Mark N. Lampert,BVF Partners OS, Ltd.,and Biotechnology Value	On Market purchase of		ordinary shares63,412 fully paid	4,000
07/10/2015		Trading Fund OS, L.P.	fully paid ordinary shares	$14,584.76	ordinary shares	63,412

	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
20/10/2015	and Biotechnology Value	On Market purchase of		100,000 fully paid
	Trading Fund OS, L.P.BVF Partners, L.P., BVF	fully paid ordinary shares	$22,950.00	ordinary shares	100,000
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of
21/10/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$1,145.00	5,000 fully paidordinary shares
	BVF Partners, L.P., BVF				5,000
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		100,000 fully paid
22/10/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$22,730.00	ordinary shares	100,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
23/10/2015	and Biotechnology Value	On Market purchase of		3,687 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$848.01	ordinary shares	3,687
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,BVF Partners OS, Ltd.,
	and Biotechnology Value
26/10/2015	Trading Fund OS, L.P.	On Market purchase of		55,005 fully paid
	BVF Partners, L.P., BVF	fully paid ordinary shares	$12,651.15	ordinary shares	55,005
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		69,995 fully paid
27/10/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$15,972.86	ordinary shares
	BVF Partners, L.P., BVF				69,995
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		23,439 fully paid
28/10/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$5,390.97	ordinary shares	23,439
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
30/10/2015	and Biotechnology Value	On Market purchase of		48,000 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$11,016.00	ordinary shares	48,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,BVF Partners OS, Ltd.,
	and Biotechnology Value
02/11/2015	Trading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$10,580.00	46,000 fully paid
	BVF Partners, L.P., BVF			ordinary shares	46,000
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		40,000 fully paid
03/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$9,200.00	ordinary shares	40,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		20,000 fully paid
04/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$4,600.00	ordinary shares	20,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,and Biotechnology Value	On Market purchase of
05/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares		60,000 fully paid
	BVF Partners, L.P., BVF		$13,674.00	ordinary shares	60,000
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		36,000 fully paid
06/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$8,276.40	ordinary shares	36,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		23,635 fully paid
09/11/2015				ordinary shares	23,635
	Trading Fund OS, L.P.	fully paid ordinary shares	$5,341.51
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		50,365 fully paid
10/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$11,583.95	ordinary shares	50,365
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
11/11/2015	and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase of		40,000 fully paid
		fully paid ordinary shares	$9,200.00	ordinary shares	40,000
	BVF Partners, L.P., BVFInc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
13/11/2015	and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares		200,000 fully paid

	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		75,000 fully paid
17/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$16,627.50	ordinary shares	75,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		15,000 fully paid
18/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$3,225.00	ordinary shares	15,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of
19/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$7,697.14	33,938 fully paid
	BVF Partners, L.P., BVF			ordinary shares	33,938
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of
20/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares		27,000 fully paid
	BVF Partners, L.P., BVF		$6,210.00	ordinary shares	27,000
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		50,000 fully paid
23/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$11,390.00	ordinary shares	50,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		34,000 fully paid
24/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$7,748.60	ordinary shares	34,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		10,000 fully paid
25/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$2,300.00	ordinary shares	10,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		93,000 fully paid
26/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares	$20,980.80	ordinary shares
	BVF Partners, L.P., BVF				93,000
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of
27/11/2015	Trading Fund OS, L.P.	fully paid ordinary shares		35,900 fully paid
	BVF Partners, L.P., BVF		$8,127.76	ordinary shares	35,900
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value
		On Market purchase of		50,100 fully paid
30/11/2015					50,100
	Trading Fund OS, L.P.	fully paid ordinary shares	$11,072.10	ordinary shares
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		92,000 fully paid	92,000
	Trading Fund OS, L.P.	fully paid ordinary shares	$20,322.80	ordinary shares
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		10,000 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$2,250.00	ordinary shares	10,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		72,000 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$18,720.00	ordinary shares	72,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
01/12/201502/12/201521/06/2016	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		20,000 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$5,200.00	ordinary shares	20,000
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			1,000,000 fully paid
	and Investment 10 LLC	paid ordinary shares	$250,800.00	ordinary shares
28/06/201612/07/2016	BVF Partners, L.P., BVF				1,000,000
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of
	Trading Fund OS, L.P.			559,639 fully paid
		fully paid ordinary shares	$139,909.75	ordinary shares	559,639
08/07/2016	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,and Biotechnology Value	On Market purchase of		90,819 fully paid

	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully
25/10/2016	and Investment 10 LLC	paid ordinary shares	$42,190.46	162,271 fully paidordinary shares	162,271
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			37,729 fully paid
25/10/2016	and MSI BVF SPV LLC	paid ordinary shares	$9,809.54	ordinary shares	37,729
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert.BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		77,000 fully paid
26/10/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$20,435.80	ordinary shares	77,000
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		246,879 fully paid
27/10/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$66,237.64	ordinary shares	246,879
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			58,448 fully paid
31/10/2016	and Investment 10 LLC	paid ordinary shares	$15,634.84	ordinary shares	58,448
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			141,552 fully paid
31/10/2016	and MSI BVF SPV LLC	paid ordinary shares	$37,865.16	ordinary shares	141,552
	BVF Partners, L.P., BVFInc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		76,121 fully paid
28/10/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$20,552.67	ordinary shares	76,121
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,	On Market sale of fully		37,710 fully paid
07/11/2016	and Investment 10 LLC	paid ordinary shares	$9,808.37	ordinary shares	37,710
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			94,344 fully paid
07/11/2016	and MSI BVF SPV LLCBVF Partners, L.P., BVF	paid ordinary shares	$24,538.87	ordinary shares	94,344
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		318,363 fully paid
03/11/2016	Trading Fund OS, L.P.BVF Partners, L.P., BVF	fully paid ordinary shares	$82,583.36	ordinary shares	318,363
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
04/11/2016	and Biotechnology Value	On Market purchase of		81,637 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$21,029.69	ordinary shares	81,637
	BVF Partners LP, BVF
08/11/2016	Inc. and Mark N. Lampert, On Market sale of fully			14,661 fully paid
	and Investment 10 LLC	paid ordinary shares	$3,811.86	ordinary shares	14,661
	BVF Partners LP, BVF
08/11/2016	Inc. and Mark N. Lampert, On Market sale of fullyand MSI BVF SPV LLC	paid ordinary shares		39,669 fully paid
			$10,313.94	ordinary shares	39,669
	BVF Partners LP, BVF
09/11/2016	Inc. and Mark N. Lampert, On Market sale of fullyand MSI BVF SPV LLC	paid ordinary shares		7,685 fully paid
			$1,998.10	ordinary shares	7,685
	BVF Partners LP, BVFInc. and Mark N. Lampert,
09/11/2016	and Investment 10 LLC	On Market sale of fullypaid ordinary shares	$1,542.06	5,931 fully paid
	BVF Partners, L.P., BVF			ordinary shares	5,931
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,and Biotechnology Value
08/11/2016	Trading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$59,895.60	228,000 fully paid
				ordinary shares	228,000
	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully
10/11/2016	and Investment 10 LLC	paid ordinary shares	$16,511.51	62,901 fully paidordinary shares	62,901

BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully137,099 fully paid10/11/2016and MSI BVF SPV LLCpaid ordinary shares$35,988.49ordinary shares137,099BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueOn Market purchase of2,536 fully paid09/11/2016Fund II LPfully paid ordinary shares$667.48ordinary shares2,536BVF Partners, L.P., BVFInc. and Mark N. Lampert.BVF Partners OS, Ltd.,and Biotechnology ValueOn Market purchase of169,464 fully paid09/11/2016Trading Fund OS, L.P.fully paid ordinary shares$44,602.92ordinary shares169,464BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueOn Market purchase of49,867 fully paid10/11/2016Fund II LPfully paid ordinary shares$12,935.50ordinary shares49,867BVF Partners, L.P., BVFInc. and Mark N. Lampert,BVF Partners OS, Ltd.,and Biotechnology ValueOn Market purchase of37,133 fully paid10/11/2016Trading Fund OS, L.P.fully paid ordinary shares$9,632.30ordinary shares37,133BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully101,806 fully paid14/11/2016and MSI BVF SPV LLCpaid ordinary shares$26,469.56ordinary shares101,806BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully44,525 fully paid14/11/2016and Investment 10 LLCpaid ordinary shares$11,576.50ordinary shares44,525BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully51,760 fully paid15/11/2016and MSI BVF SPV LLCpaid ordinary shares$13,457.60ordinary shares51,760BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully51,833 fully paid15/11/2016and Investment 10 LLCpaid ordinary shares$13,476.58ordinary shares51,833BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueOn Market purchase of121,617 fully paid11/11/2016Fund II LPfully paid ordinary shares$31,255.57ordinary shares121,617BVF Partners, L.P., BVFInc. and Mark N. Lampert.BVF Partners OS, Ltd.,and Biotechnology ValueOn Market purchase of35,383 fully paid11/11/2016Trading Fund OS, L.P.fully paid ordinary shares$9,093.43ordinary shares35,383BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully0,037 fully paid16/11/2016and Investment 10 LLCpaid ordinary shares$9.62ordinary shares37BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully0,039 fully paid16/11/2016and MSI BVF SPV LLCpaid ordinary shares$10.14ordinary shares39BVF Partners LP, BVFInc. and Mark N. Lampert.and Biotechnology ValueOn Market purchase of91,920 fully paid14/11/2016Fund II LPfully paid ordinary shares$23,899.20ordinary shares91,920BVF Partners, L.P., BVFInc. and Mark N. Lampert,BVF Partners OS, Ltd.,and Biotechnology ValueOn Market purchase of14,080 fully paid14/11/2016Trading Fund OS, L.P.fully paid ordinary shares$3,660.80ordinary shares14,080BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully47,985 fully paid17/11/2016and MSI BVF SPV LLCpaid ordinary shares$12,476.10ordinary shares47,985BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully44,854 fully paid17/11/2016and Investment 10 LLCpaid ordinary shares$11,662.04ordinary shares44,854BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueOn Market purchase of113,654 fully paid
ordinary shares113.654	15/11/2016	Fund II LP	fully paid ordinary shares	$29,550.04

	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,BVF Partners OS, Ltd.,
	and Biotechnology Value
15/11/2016	Trading Fund OS, L.P.	On Market purchase of		36,346 fully paid
		fully paid ordinary shares	$9,449.96	ordinary shares	36,346
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert.
	and Biotechnology Value	On Market purchase of		185,139 fully paid
16/11/2016	Fund II LP	fully paid ordinary shares	$47,784.38	ordinary shares	185,139
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		54,861 fully paid
16/11/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$14,159.62	ordinary shares	54,861
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully
18/11/2016	and Investment 10 LLC	paid ordinary shares		21,351 fully paid
			$5,551.26	ordinary shares	21,351
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			22,221 fully paid
18/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$5,777.46	ordinary shares	22,221
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,
	and Biotechnology Value	On Market purchase of		120,153 fully paid
17/11/2016	Fund II LP	fully paid ordinary shares	$30,711.11	ordinary shares	120,153
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
17/11/2016	and Biotechnology Value	On Market purchase of		33,701 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$8,613.98	ordinary shares	33,701
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully
21/11/2016	and Investment 10 LLC	paid ordinary shares	$875.16	3,366 fully paid
				ordinary shares	3,366
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			6,232 fully paid
21/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$1,620.32	ordinary shares	6,232
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,
	and Biotechnology Value	On Market purchase of		99,301 fully paid
18/11/2016	Fund II LPBVF Partners, L.P., BVF	fully paid ordinary shares	$25,570.01	ordinary shares	99,301
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value
18/11/2016	Trading Fund OS, L.P.	On Market purchase offully paid ordinary shares		31,560 fully paid
			$8,126.70	ordinary shares	31.560
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			17,784 fully paid
22/11/2016	and Investment 10 LLC	paid ordinary shares	$4,623.84	ordinary shares	17,784
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			33,893 fully paid
22/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$8,812.18	ordinary shares	33,893
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert.
	and Biotechnology Value	On Market purchase of
21/11/2016	Fund II LP	fully paid ordinary shares		90,876 fully paid
	BVF Partners, L.P., BVF		$23,373.31	ordinary shares	90,876
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		24,409 fully paid
21/11/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$6,277.99	ordinary shares	24,409
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			15,650 fully paid
23/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$4,069.00	ordinary shares	15,650
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully
23/11/2016	and Investment 10 LLC	paid ordinary shares		8,211 fully paid
			$2,134.86	ordinary shares	8,211
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,
	and Biotechnology Value	On Market purchase of		75,655 fully paid
22/11/2016	Fund II LP	fully paid ordinary shares	$19,670.30	ordinary shares	75,655

$\tilde{D}^{\prime}_{1}$

	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,and Biotechnology Value
22/11/2016	Trading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$6,329.70	24,345 fully paid
				ordinary shares	24,345
	BVF Partners LP, BVF	Inc. and Mark N. Lampert, On Market sale of fully
24/11/2016	and Investment 10 LLC	paid ordinary shares	$11,258.52	43,302 fully paid
				ordinary shares	43,302
	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully
24/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$20,604.22	79,247 fully paidordinary shares
					79,247
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,and Biotechnology Value	On Market purchase of
23/11/2016	Fund II LP	fully paid ordinary shares	$4,364.58	17,116 fully paidordinary shares	17,116
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,and Biotechnology Value	On Market purchase of
23/11/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$2,010.42	7,884 fully paidordinary shares
					7,884
	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully
25/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$435.76	1,676 fully paidordinary shares	1,676
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,	On Market sale of fully
25/11/2016	and Investment 10 LLC	paid ordinary shares	$257.66	0,991 fully paidordinary shares	991
	BVF Partners LP, BVFInc. and Mark N. Lampert,
	and Biotechnology Value	On Market purchase of		41,925 fully paid
25/11/2016	Fund II LP	fully paid ordinary shares	$10,934.04	ordinary shares	41,925
	BVF Partners, L.P., BVF
	Inc. and Mark N. Lampert.BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		18,075 fully paid
25/11/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$4,713.96	ordinary shares	18,075
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			24,912 fully paid
29/11/2016	and MSI BVF SPV LLC	paid ordinary shares	$6,601.68	ordinary shares	24,912
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert, On Market sale of fully			14,736 fully paid
29/11/2016	and Investment 10 LLC	paid ordinary shares	$3,905.04	ordinary shares	14,736
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert,
	and Biotechnology Value	On Market purchase of		46,652 fully paid
12/12/2016	Fund II LPBVF Partners, L.P., BVF	fully paid ordinary shares	$12,129.52	ordinary shares	46,652
	Inc. and Mark N. Lampert,
	BVF Partners OS, Ltd.,
	and Biotechnology Value	On Market purchase of		13,348 fully paid
12/12/2016	Trading Fund OS, L.P.	fully paid ordinary shares	$3,470.48	ordinary shares	13,348
	BVF Partners LP, BVF
14/12/2016	Inc. and Mark N. Lampert, On Market sale of fully			171,305 fully paid
	and Investment 10 LLC	paid ordinary shares	$45,053.22	ordinary shares	171,305
	BVF Partners LP, BVF
14/12/2016	Inc. and Mark N. Lampert, On Market sale of fullyand MSI BVF SPV LLC			28,695 fully paid
		paid ordinary shares	$7,546.79	ordinary shares	28,695
	BVF Partners LP, BVF
	Inc. and Mark N. Lampert.
13/12/2016	and Biotechnology ValueFund II LP	On Market purchase offully paid ordinary shares		38,283 fully paid
	BVF Partners, L.P., BVF		$9,953.58	ordinary shares	38,283
	Inc. and Mark N. Lampert.
	BVF Partners OS, Ltd.,
13/12/2016	and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares		1,717 fully paid
			$446.42	ordinary shares	1,717
	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fully
15/12/2016	and Investment 10 LLC	paid ordinary shares	$52,060.00	200,000 fully paid
				ordinary shares	200,000

	BVF Partners LP, BVFInc. and Mark N. Lampert.and Biotechnology Value
15/12/2016	Fund II LP	On Market purchase offully paid ordinary shares	$37,462.62	144,087 fully paid
	BVF Partners, L.P., BVFInc. and Mark N. Lampert.			ordinary shares	144,087
15/12/2016	BVF Partners OS, Ltd.,and Biotechnology Value	On Market purchase of		45,913 fully paid
	Trading Fund OS, L.P.	fully paid ordinary shares	$11,937.38	ordinary shares	45,913
19/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market sale of fullyand Investment 10 LLC	paid ordinary shares	$39,445.21	151,654 fully paidordinary shares	151,654
	BVF Partners, L.P., BVFInc. and Mark N. Lampert.BVF Partners OS, Ltd.,and Biotechnology Value
16/12/2016	Trading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$4,046.12	15,562 fully paidordinary shares	15,562
16/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueFund II LP	On Market purchase of		60,621 fully paid
		fully paid ordinary shares	$15,761.46	ordinary shares	60,621
16/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market purchase ofand Investment 10 LLC	fully paid ordinary shares	$8,792.42	33,817 fully paidordinary shares	33,817
19/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert,and Biotechnology ValueFund II LP	On Market purchase offully paid ordinary shares	$8,613.67	33,155 fully paid
				ordinary shares	33,155
19/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market purchase ofand Investment 10 LLC	fully paid ordinary shares	$1,242.62	4,783 fully paidordinary shares	4,783
19/12/2016	BVF Partners, L.P., BVFInc. and Mark N. Lampert.BVF Partners OS, Ltd.,and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$3,133.71	12,062 fully paidordinary shares	12,062
20/12/2016	BVF Partners, L.P., BVFInc. and Mark N. Lampert,and Biotechnology Value	On Market purchase of		1,364 fully paid
	Fund, L.P.BVF Partners LP, BVF	fully paid ordinary shares	$354.64	ordinary shares	1,364
20/12/2016	Inc. and Mark N. Lampert.and Biotechnology ValueFund II LP	On Market purchase offully paid ordinary shares	$9,030.32	34,732 fully paidordinary shares	34.732
20/12/2016	BVF Partners, L.P., BVFInc. and Mark N. Lampert.BVF Partners OS, Ltd.,and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$2,404.22	9,247 fully paidordinary shares	9,247
20/12/2016	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market purchase ofand Investment 10 LLC	fully paid ordinary shares		4,657 fully paid
	BVF Partners, L.P., BVF		$1,210.82	ordinary shares	4,657
31/03/2017	Inc. and Mark N. Lampert.and Biotechnology ValueFund, L.P.	On Market purchase offully paid ordinary shares	$2,004,494.98	7,564,132 fully paidordinary shares	7,564,132
31/03/2017	BVF Partners LP, BVFInc. and Mark N. Lampert.and Biotechnology ValueFund II LP	On Market purchase offully paid ordinary shares	$1,372,630.31	5,179,737 fully paidordinary shares
	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market purchase of				5,179,737
31/03/2017	and Investment 10 LLCBVF Partners, L.P., BVFInc. and Mark N. Lampert.	fully paid ordinary shares	$367,686.18	1,387,495 fully paidordinary shares	1,387,495
31/03/2017	BVF Partners OS, Ltd.,and Biotechnology ValueTrading Fund OS, L.P.	On Market purchase offully paid ordinary shares	$310,265.98	1,170,815 fully paidordinary shares	1,170,815
31/03/2017	BVF Partners LP, BVFInc. and Mark N. Lampert, On Market purchase ofand MSI BVF SPV LLC	fully paid ordinary shares	$428,867.52	1,618,368 fully paid
				ordinary shares	1,618,368

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

			in young securities arter the change are as follows
Holder ofrelevantinterest	Registeredholder ofsecurities	Personentitledto beregisteredas holder (8)	Nature ofrelevantinterest (6)	Class andnumber ofsecurities	Person's votes
BVF Partners.L.P.	Biotechnology ValueFund, L.P, Biotechnology Value Fund, L.P,Value Fund II, L.P.Biotechnology ValueTrading Fund OS, L.P.,Investment 10 LLC, MSIBVF SPV, LLC, as pertheir relevant interestsbelow.	BiotechnologyBiotechnologyValue Fund II.L.P,BiotechnologyValue TradingFund OS, L.P.,Investment 10LLC, MSI BVFSPV, LLC, as pertheir relevantinterests below.	Relevant interest arisesunder section 608(1)(b) ofthe Corporations Act 2001(Cth) (Corporations Act)by virtue of BVF Partners,L.P. (i) acting as generalpartner of, and/or (ii) actingas investment manager of,respectively, the registeredholders of the securities.whereby it holds theauthority to cast votes inrespect of the securities.	60,423,669 fully paidordinary shares	60,423,669
BVF Inc. andMark N.Lampert	Biotechnology ValueFund, L.P, Biotechnology Value Fund, L.P,Value Fund II, L.P.Biotechnology ValueTrading Fund OS, L.P.,Investment 10 LLC, MSIBVF SPV, LLC, as pertheir relevant interestsbelow.	BiotechnologyBiotechnologyValue Fund II.L.P,BiotechnologyValue TradingFund OS, L.P.,Investment 10LLC, MSI BVFSPV, LLC, as pertheir relevantinterests below.	Relevant interest arisesunder section 608(3)(b) ofthe Corporations Act aseach of BVF Inc. and MarkN. Lampert controls BVFPartners, L.P.	60,423,669 fully paidordinary shares	60,423,669
BVF PartnersOS Ltd.	Biotechnology ValueTrading Fund OS, L.P.	BiotechnologyValue TradingFund OS, L.P.	Relevant interest arisesunder section 608(1)(b) ofthe Corporations Act byvirtue of BVF Partners OS.Ltd. acting as generalpartner of BiotechnologyValue Trading Fund OS,L.P., a registered holder ofsecurities, whereby it holdsthe authority to cast votes inrespect to the securities.	5,040,839 fully paidordinary shares	5,040,839
BiotechnologyValue TradingFund OS, L.P.	Biotechnology ValueTrading Fund OS, L.P.	BiotechnologyValue TradingFund OS, L.P.	Relevant interest arisesunder section 608(1)(a) ofthe Corporations Act asholder of the securities	5,040,839 fully paidordinary shares	5,040,839
BiotechnologyValue Fund,L.P.	Biotechnology ValueFund, L.P.	BiotechnologyValue Fund, L.P.	Relevant interest arisesunder section 608(1)(a) ofthe Corporations Act asholder of the securities	27,649,910 fully paidordinary shares	27,649,910
BiotechnologyValue Fund II.L.P.	Biotechnology ValueFund II, L.P.	BiotechnologyValue Fund II,L.P.	Relevant interest arisesunder section 608(1)(a) ofthe Corporations Act asholder of the securities	18,097,097 fully paidordinary shares	18,097,097
Investment 10LLC	Investment 10 LLC	Investment 10LLC	Relevant interest arisesunder section 608(1)(a) ofthe Corporations Act asholder of the securities	3,016,729 fully paidordinary shares	3,016,729
MSI BVF SPV,LLC	MSI BVF SPV, LLC	MSI BVF SPV,LLC	Relevant interest arisesunder section 608(1)(a) ofthe Corporations Act asholder of the securities	6,619,094 fully paidordinary shares	6,619,094

5. Changes in association

The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Nameandapplicable)	ACN/ARSN	(if	Nature of association
Not applicable			Not applicable

6. Addresses

The addresses of persons named in this form are as follows:

Name	Address
BVF Partners LPBiotechnology Value Fund, L.P.Biotechnology Value Fund II, L.P.BVF Inc.	One Sansome Street, 30 th FloorSan Francisco, California 94104United States of America
BVF Partners OS, LtdBiotechnology Value Trading Fund OS.L.P.	PO Box 309Ugland HouseGrand Cayman, KY1-1104Cayman Islands
Investment 10 LLC	900 North Michigan Avenue, Suite 1100Chicago, Illinois 60611United States of America
MSI BVF SPV, LLC	c/o Magnitude Capital, L.L.C.601 Lexington Avenue, 59th FloorNew York, NY 10022
Mark N. Lampert	c/o BVF IncOne Sansome Street, 30 th FloorSan Francisco, California 94104United States of America

Signature
	print name	BVF Partners LP BY BVF Inc., its general partner, BY Mark N. Lampert,President	capacity	General Partner andAttorney-in-Fact for theSubstantial Holders
	sign here	1417	date	04/04/2017