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SYNTARA LIMITED Major Shareholding Notification 2005

Nov 16, 2005

65830_rns_2005-11-16_f3f94230-204d-49b4-ad48-b9fb1a300b35.pdf

Major Shareholding Notification

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MALLESONS STEPHEN JAQUES

Confidential communication

16 November 2005

Australian Stock Exchange Limited Company Announcements Fax 1900 999 279

Pharmaxis Limited

We act for Orbis Global Equity Fund Limited and enclose a notice under Part 6C.1 of the Corporations Act 2001 (Cth).

Yours faithfully

Damien Scholefield Senior Associate Direct line +61 2 9296 2463 Email [email protected]

Level 60 Governor Phillip Tower 1 Farrer Place Sydney NSW 2000 Australia T+61 2 9296 2000 DX 113 Sydney ABN 22-041-424-954. [email protected] www.mallesons.com F +61 2 9296 3999

8186366_Ldoc / 02-5132-9165 / DSCHOLEF

Page 1 of 14

$#$

Form 603

Corporations Act 2001

Section 671B

Notice of initial substantial holder

To Company Name/Scheme. Pharmaxis Limited
ACN/ARSN/ABN 75 082 811 630
1. Details of substantial holder (1) $\cdots$
Name Orbis Global Equity Fund Limited and the entities listed in table 1 of annexure A
ACN/ARSN (if applicable). пa
The holder became a substantial holder on 11 /11/05
2. Octails of voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in on the date the substantial holder became a substantial holder are as follows:

------------------------------------------ _____________
1.11-191. MInfluent-------------------------------------- APR ,,,,,,,,,,- 3
__________SAMPLE AT ______TEE OOO ----100 000 000 000 000 000 000 000 000 000

3. Details of relevant interests

The nature of the relevant interest the substantial holder or an associate had in the following voting securities on the date the substantial holder bocame a substantial holder are as follows:

Holder of relevant interest Nature of relevant interest (7) Class and number of securities
Orbia Global Equity Fund Limited Acouisition of shares-Share Placement Agreement$ -$ Ordinary 16 300,000
See Annexure A. (lable 1 and 2) . See Annexure B

4. Details of present registered holders

The persons registered as holders of the securities referred to in paragraph 3 above are as follows:

Holder of relevantinterest. Registered holder ofsocunties. Person entitled to beregistered as holder (8). Class and number.of securities
Orbis Global Equity FundLimitad No HSBC Custody Nominees(Australia) Ltd as nominee of OrbisGlobal Equity Fund Limited(no current registered holder) Ordinary 16,300,000
See Annexure A (table 1 and 2)

5. Consideration

The consideration paid for each relevant interest referred to in paragraph 3 above, and acquired in the four months prior to the day that the substantial holder became a substantial holder is as follows:

Holder of relevant interest Date of acquisition Consideration (9) Class and number ofsecurities
Non-CashCash
Orbis Global Equity FundLimited 11/11/05 $35,860,000 (to be paid on11/11/05 Ordinary 16,300,000
. See Annexura A (table 1and 2) $\cdots$. $\sim$

1603 pharmaaxis(14 11) (2)

6. Associates

The reasons the persons named in paragraph 3 above are associates of the substantial holder are as follows:

$\mathcal{A}$ $\sim$

$\alpha$

.
Name and ACN/ARSN (if applicable) Nature of association
See Annexure A (table 1 and 2).
---------------------------------------
$\sim$ . .

$\mathbb{R}^2$ $\sim$ $\sim$

$\mathbb{C}$

l,

7. Addresses

÷.

$\overline{a}$

Name Address
Orbis: Global Equity Fund Limited LPG Building, 34 Sermudiana Road, Hamilton, HM11, Bermuda
See Annexure A (teble 1 and 2)
Signature
print name Capacity
D3×.Jami Director/Officer/Authonsed Signatory
sign here: date 15 / 11 / 2005
DIRECTIONS
paragraph 7 of the form.See the definition of "associate" in section 9 of the Corporations Act 2001. reteried to throughout the form as a specifically named group if the membership of each group, with the names and addresses of members is dearly set out in
See the definition of "relevant Interest" in sections 608 and 671B(7) of the Corporations Act 2001,The voting shares of a company constitute one class unless divided into separate classes.The total number of votes attached to all the voting shares in the company or voting interests in the scheme (if any) that the person or an associate has a relevant
interest in.
The person's votes divided by the total votes in the body corporate or scheme multiplied by 100.
(2)(*)(4)60 Include details of
any relevant agreement or other circumstances by which the relevant interest was acquired. If subsection 671B(4) applies, a copy of any document(a)satting out the terms of any relevant agreement, and a statement by the person giving full and accurate details of any contract, scheme orarrangement, must accompany this form, together with a written statement certifying this contract, scheme or arrangement; and
any qualification of the power of a person to exercise, control the exercise of, or influence the exercise of, the voting powers or disposal of the(h)securities to which the relevent interest relates (indicating clearly the particular securities to which the qualification applies).
See the definition of "relevant agreement" in saction 9 of the Corporations Act 2001.
(6) If the substantial holder is unable to determine the identity of the person (eg if the relevant interest anses because of an option) write "unknown".

$3 / 14$

$\sharp$

15 7 11 72005

date

PHARMAXIS LIMITED ACN 75 082 811 630

$\sim$ $\mu$

THIS IS ANNEXURE A OF 3 PAGES REFERRED TO IN FORM 603

Table 1

Name and address ofsubstantial holder /associate Nature ofrelevantinterest Class anddumber ofsecurities Consideration(to be paid on11/11/05) Person entitledto be registeredholder of Nature ofassociation
securities (nocurrent.registeredholder)
Orbis Capital Limited ofLPG Building, 34Bermudiana Road.Hamilton, HM11,Bermuca Acquisitionof shares -Share -placementagreement 865,000Ordinaryshares $1,904,500 HSBC CustodyNominees.(Australia) Ltd asnominee of OrbisCapital Limited Controlled byOrbisHoldingsLimited
Orbis Optimal SA FundLimited of LPG Building,34 Bermudiana Road.Hamilton, HM11Bermuda Acquisitionof shares -Shareplacementagreement 1670,000Ordinaryshares! $1,474,000 WestpacCustodianNominees Ltd asnominee of Orbis.Optimal SA Fund.Limited Controlled byOrbisHoldingsLimited
Orbis SICAV GlobalEquity Fund of LPGBuilding, 34 BermudianaRoad, Hamilton, HM11,Bermuca Acquisitionof shares -Share -placementagreement 1,290,000Ordinaryshares $2,838,000 WestpacCustodianNominees Ltd asnominee of OrbisSICAV GlobalEquity Fund Controlled byaidnOHoldingsLimited
Orbis Optimal GlobalFund LP of LPG Building.34 Bermudiana Road.Hamilton, HM11,Bermuda Acquisitionof shares -Shareplacementagreement 2150,000Ordinarvsharesi $550,000 Westpac.CustodianNominees Ltd asnominee of OrbisOptimal GlobalFund - Controlled byOmisHoldingsLimited
Orbis MIS Orbis GlobalEquity Fund of Level 2.575 Bourke StreetMelbourne VIC 3000 Acquisitionof sharesShareplacementagreement 390,000Ordinaryshares $858,000 WestpacCustodianNominees Ltd asnominee of OrbisMIS Orbis GlobalFor ity Fund Controlled byOrbisHoldingsLimited

Table 2

The following entities, by reason of their relationship as associates, have a relevant interest in 19,765,000 ordinary securities of Pharmaxis Limited.

Name: - Address ACN$1 - 1 = 1$ Nature of association
Orbis Holdings Limited LPG Building, 34 п/а Controlling shareholder of
Bermudiana Road substantial holders.
Hamilton HM 11
Bermuda
Pictet Overseas TrustCorporation and Pictet.Trustee Company SA Bayside Executive ParkWest Bay StreetNassau, Bahamas n/a Controlling entity of Orbis HoldingsLimited

iAlb

$\hat{\boldsymbol{\theta}}$

I

$\bar{\beta}$

$\ddot{\phantom{0}}$

$#$

Name: Address ACN Nature of association
Orbis World Limited LPG Building, 34Bermudiana Road, n/a Controlling entity of Orbis HoldingsLimited
Hamilton HM 11.Bermuda
Orbis Investment LPG Building, 34 n/a Controlled by Orbis Holdings Limited
Management Limited Bermudiana Road,Hamilton HM 11,Bermuda
Orbis Asset Management LPG Building, 34 nia Controlled by Orbis Holdings Limited
Limited. Bermudiana Road,
Hamilton HM 11,Bermuda
Orbis Leveraged Global LPG Building, 34 n/a Controlled by Orbis Holdings Limited
Fund L.P. Bermudiana Road,Hamilton HM 11,
Bermuda
Orbis Administration LPG Building, 34 n/a Controlled by Orbis Holdings Limited.
Limited Bermudiana Road,Hamilton HM 11.
Bermuda
Orbis Investment 1017,3 Danji Kings n/a Controlled by Orbis Holdings Limited
Research Limited Garden Office 72, Naesu-Dong Jongro-Gu Seoul:
1110-070 Korea
Orbis InvestmentManagement (MIS)Limited LPG Building, 34Bermudiana Road,Hamilton HM 11.Bermuda n/a. Controlled by Orbis Holdings Limited
Triple Blue Holdings Romasco Place n/a
Limited Wickhams:Cay TPO Box 3140 Controlled by Orbis Holdings Limited
Road Town, TortolaBritish Virgin Islands
Orbis Mansfield Street Romasco Place n/a Controlled by Orbis Holdings Limited
Properties Ltd Wickhams Cay 1.PO Box 3140
Road Town, TortolaBritish Virgin Islands
Orbis Investment LPG Building, 34 n/a Controlled by Orbis Holdings Limited
Management (BVI)Limited Bermudiana Road,Hamilton HM 11.
Bermuda
Orbis Investment AdvisoryPty Limited Level 2 Challis House4 Martin Place 101 387 964 Controlled by Orbis Holdings Limited
Sydney NSW 2000
Orbis Holdings (Australia) Level 2 Challis House 112315625 Controlled by Orbis Holdings Limited
Pty Limited 4 Martin PlaceSydney NSW 200
Name Address ACN Nature of association
Orbis InvestmentManagement (Australia)Pty Limited Level 2 Challis House4 Martin PlaceSydney NSW 200 112.316.168 Controlled by Orbis Holdings Limited
Orbis Optimal (US$) FundLimited LPG Building, 34Bermudiana Road.Hamilton HM 11,Bermuda n/a Controlled by Orbis Holdings Limited
Orbis Leveraged (US$)Fund Limited LPG Building, 34Bermudiana Road,Hamilton HM 11.Bermuda n/a Controlled by Orbis Holdings Limited
Orbis Africa Equity (Rand)Fund Limited LPG Building, 34Bermudiana Road,Hamilton HM 11,Bermuda n/a Controlled by Orbis Holdings Limited
Orbis Optimal (Euro)Fund Limited LPG Building, 34Bermudiana Road.Hamilton HM 11.Bermuda. n/a Controlled by Orbis Holdings Limited
Orbis Leveraged (Euro)Fund Limited LPG Building, 34Bermudiana Road,Hamilton HM 11.Bermuda n/a Controlled by Orbis Holdings Limited
Orbis Japan OpportunityMaster Fund Limited LPG Building, 34Bermudiana Road,Hamilton HM 11,Bermuda n/a: Controlled by Orbis Holdings Limited
Orbis Japan Equity (US$)Fund Limited LPG Building, 34Bermudiana Road.Hamilton HM 11.Bermuda - r/a Controlled by Orbis Holdings Limited
Orbis Access Limited LPG Building, 34Bermudiana Road,Hamilton HM 11,Bermuda. n/a. Controlled by Orbis Holdings Limited

PHARMAXIS LIMITED ACN 75 082 811 630

THIS IS ANNEXURE B OF 10 PAGES REFERRED TO IN FORM 603

$\mathcal{L}$ date 15 / 11 / 2005

NO. 4531 P. 2

PXS23

  1. NOV. 2005 14:15

Wilson HTM Limited ABN 58 010 529 685 LeversRoyal Exchange BuildingSo Pill StreetSydney NSW 2000Tel. 51 2 8247 6621Fax 61 2 8247 6621

www.wilson/rtm.com.au

Private and Confidential

Monday 7th November 2005

Email: [email protected], 8 pages

URGENT FAX ACCEPTANCE REQUIRED BY 5PM Monday 7th November 2005

Dear Steve

Pharmaxis Ltd (the "Company") PLACEMENT OF NEW FULLY PAID ORDINARY SHARES AT $2.20 PER SHARE

WILSON HTM 61 2 8247 6601

$\mathbf{1}$ Introduction

On behalf of the Company, Wilson HTM Limited (the "Placement Agent"), is pleased to confirm yourinvitation to acquire new fully paid ordinary shares in the Company through the placement of new fully paid ordinary shares in the Company ("Placement Shares"), at an issue price of $2.20 per Placement .Share.

The Company has engaged the Placement Agent to arrange the placement of up to 19.9 million Placement Shares with investors in Australia and other jurisdictions outside the United States (the "Placement"). The Company is also proposing to offer in the United States (the "US Offer") 18.6 million new fully paid ordinary shares with the ability to accept over subscriptions of an additional 4.2 mRlion ordinary shares (the "Overallotment Option"). The Placement, the US Offer and the Overallotment Option are referred to in this letter as the "Global Offers".

You are being offered Placement Shares under this letter of offer (the "Placement Offer Letter") which have already received shareholder approval on 28 October 2005.

$\mathbf{Z}$ Use of Proceeds

The Company has informed us that the funds raised in the Global Offers will be used for the following

  • to fund clinical development of Bronchitol in patients with cystic fibrosis;
  • to fund clinical development of Aridol for management of asthma and chronic obstructive pulmonary $\bullet$ disease;
  • to prepare for the commercial launch of Aridot for the management of asthma;
  • . to fund the clinical development of Bronchitol in patients with bronchiectasis and chronic bronchitis;
  • . to fund pre-clinical development of the Company's product pipeline;
  • to fund further expansion of the Company's manufacturing facilities;
  • to accelerate the commercialization and investigate additional indications for Bronchitol;
  • to fund working capital; and
  • · for general corporate purposes, including capital expenditures.
  1. NOV. 2005 14:15

NO. 4531 P. 31

WILSON HTM 61 2 8247 6601

The Company has also informed us that a portion of the net proceeds may also be used to in-license product candidates, enter into future collaborations or invest in businesses or technologies that it believes are complementary to its own; and the Company has no present understandings, commitments or are compressionally to the critic and completely the increase processingly com-

$\overline{\mathbf{3}}$ . Placement Offer

The Placement Agent is pleased to confirm that you have been allocated up to the following Placement Shares in the Placement ("Offer"), subject to the terms set out below in this Placement Offer Letter.

Number ofShares. --Issue Price Total Amount
Allocation 3,500,000 ____52.20$\sim$ Advances and Links and AdvancesA$7,700,000

Details of the transaction are proposed to be approved by the Pharmaxis Board on the morning of Tuesday 8th November 2005.

In making an investment decision to participate in the Placement in accordance with the provisions of this Placement Offer Letter, you must rely on your own examination of the Company and the terms and conditions of the offer to participate in the Placement, including the merits and risks involved. Your allocation may be scaled back at the discretion of the Placement Agent depending on the level of demand for the Placement Shares.

Australia

The Offer is being made to Australian residents on the basis that you are a Sophisticated Investor or Professional Investor (pursuant to sections 708(8) and 708(11) of the Corporations Act 2001 (Commonwealth), (the "Act") so that the Offer can be made without the need for disclosure under Part 60.2 of the Act.

Other Jurisdictions

The Placement Shares are not offered or sold in any other jurisdiction by means of this Placement Offer Letter or otherwise, unless the Offer is in accordance with the laws of that jurisdiction as may apply to the Offer and sale of the Placement Shares.

4 Timetable

The indicative Placement timetable is as follows:

Return of Placement Acceptance Advice 5PM, 7th November 2005
CARD Form (settlement details) due to Wilson HTM 5PM, 7 th November 2005
DyP Settlement in CHESS 1 th November 2005
Application and Expected date of ASX quotation ofPlacement Shares 14th November 2005

Please note that the above timetable is indicative only and may change without consultation with you and, subject to the terms of this Placement Offer Letter, you are bound by the agreement arising from your irrevocable acceptance of this Offer notwithstanding any such changes to the timetable. All times above are references to Sydney, Australia time.

5. Rights Attaching to the Placement Shares

When issued, the Placement Shares will rank part passu with the Company's existing ordinary shares including in respect of distributions. The Company has agreed to apply to Australian Stock Exchange 7, NOV, 2005 14:16

WILSON HTM 6: 2 8247 6501

$-3-$

Limited ("ASX") for official quotation of the Placement Shares on ASX. Please note that a Participant (as defined in the ASTC Settlement Rules) cannot deal in the Placement Shares either as principal or agent until official quotation is granted in respect of the Placement Shares.

6. Offer Personal

The Offer of Placement Shares and the agreement arising from the acceptance of the Offer is personal to you and you may not:

  • $(n)$ assign;
  • $(b)$ transfer: or
  • $(c)$ in any other manner deal with,

your entitiement to the Placement Shares or the Placement Shares or your rights or obligations under the agreement arising from your irrevocable acceptance of the Offer.

$\overline{7}$ Placement Agreement

The Placement Agent and the Company have entered into a placement agreement (the "Placement Agreement").

The Placement Agreement contains customary termination provisions which entitles either the Placement Agent or the Company to terminate the Placement Agreement.

If either the Company or the Placement Agent chooses to terminate the Placement Agreement, your rights under this Placement Offer Letter will end including your right to receive the Placement Shares. In this case, your application monies will be refunded to you and you are not entitled to claim any interest on the application monies or any loss, damage or liability suffered or incurred as a result of or in connection with the termination of the Placement Agreement or otherwise.

If the Placement Agent chooses not to terminate its involvement in the Placement Agreement in circumstances where the Placement Agent is entitled to do so (or the Placement Agent chooses not to exercise any other right it may have under the Placement Agreement), you will be and remain bound by such election and will be and remain bound to fulfil all your obligations pursuant to this Placement Offer Letter.

The Placement Agent will be paid customary fees for their services in the Placement.

Corporations Act relief for the Placement 8.

No disclosure document has been prepared or will be issued by the Company in connection with the Placement. Accordingly, the Placement Shares will only be issued to one of the categories of investors to whom such an issue can be made without a disclosure document under the Act.

If you on-sell the Placement Shares within twelve months from their issue to you pursuant to this agreement, you may be required to create and lodge a prospectus with ASIC unless:

  • $(a)$ that sale is to another Sophisticated Investor, Professional Investor, or other class of person to whom offers for sale of the Placement Shares can be made without disclosure under the Act; or
  • (b) it can be established that the Company has complied with the requirements of section 708A of the Am.

Under the Placement Agreement, the Company has agreed to, within 5 Business Days from the issue of the Placement Shares, give ASX a notice under section 708A of the Act that:

$(a)$ the Company issued the Placement Shares without disclosure to investors under Part 6D.2 of the Act; and

$(\mathbf{c})$

  1. NOV. 2005 14:16

WILSON HTM 61 2 8247 6601

NO. 4531 $P. 5.$

$-4-$

  • (b) stating that the notice is being given under section 708A(5)(e) of the Act; and
    • stating that as at the date of the notice, the Company has complied with:
      • $(1)$ the provisions of Chapter 2M of the Act as they apply to the Company; and
      • $(ii)$ section 674 of the Act: and

sets out any information that is excluded information (as specified in sections 708A(6), 708A(7) and 708A(8) of the Act) as at the date of the notice.

However, your ability to on-sell the Placement Shares within twelve months from their issue may be affected if certain conditions under section 708A of the Act no longer apply.

$\bullet$ . Representations, Warranties and Agreements

By accepting the Offer of Placement Shares, you represent, warrant and agree for the benefit of the Company, the Placement Agent and their respective related bodies corporate and their respective directors, officers, employees and advisers that:

  • $(a)$ If you are resident in Australia, you fall within one of the following categories:
    • a "Sophisticated Investor" pursuant to section 708(8) of the Act; or $(1)$
    • $(n)$ a "Professional Investor" within the meaning of section 9 and pursuant to section 708(11) of the Act.
  • $(b)$ You are not now, and you will not be at the time of subscribing for the Ptacement Shares, in the United States, nor are you a U.S. person for the purposes of the Regulations S under the U.S. Securities Act of 1933, as amended (the "Securities Act"), and you are subscribing for the Placement Shares outside the United States in an "offshore transaction" (as such term is defined in Rule 902(h) under the Securities Act).
  • If you are resident outside Australia, you are entitled to accept the Offer, in accordance with its $\langle \mathbf{c} \rangle$ terms and conditions herein stated under the law of the jurisdiction in which you accept the Offer.
  • $(a)$ Your purchase of the Placement Sharos is in compliance with all relevant laws and regulations (including, without limitation, the requirements of the Australian Foreign Acquisitions and Takeovers Act 1975).
  • $(e)$ You are aware that publicly available information about the Company can be obtained from the Australian Securities and Investments Commission and ASX (including its web site http://www.asx.com.au).
  • You have had access to all information that you believe is necessary or appropriate in connection (f) with your acceptance of the Offer to purchase the Placement Shares. You acknowledge and agree that you will not hold the Placement Agent or any of its related bodies corporate, their respective directors, officers, employees and advisers responsible for any misstatements in, or omissions from, any publicly available information concerning the Company.
  • You have made and relied upon your own assessment of the Company and have conducted your $\left( 2 \right)$ own investigation with respect to the Placement Shares and the Company including, without limitation, the particular tax consequences of purchasing, owning or disposing of the Placement Shares in light of your particular situation as well as any consequences arising under the laws of any other taxing jurisdiction.
  • You have not relied on any investigation that the Placement Agents or any of its related bodies (h) corporate or any persons acting on their behalf may have conducted with respect to the Placement Shares or the Company. None of such persons has made any representation to you, express or implied, with respect to the Placement Shares or the Company.

$(1)$

$(i)$

$(0)$

$\phi$

$(m)$ $(n)$

$(0)$

$(p)$

$\left( 0 \right)$

$(r)$

$(5)$

agreements.

$11.$

7, NOV, 2005 14:16

WILSON HTM 61 2 8247 6601

NO. 4531 $P_{\rm{eff}}$ 6

$5.5.$ If you are acquiring any Placement Shares on account of one or more persons, you have full power to make the foregoing acknowledgements, representations, warranties and agreements on behalf of each such person and you will take reasonable steps to cosure that each such person will comply with its obligations herein. You are not a Related Party (as defined in the ASX Listing Rules) or associate of the Company. You acknowledge that no disclosure document has been prepared in connection with the Placement. You acknowledge that the Offer does not constitute a securities recommendation. You acknowledge that the acquisition of the Placement Shares involves a high degree of risk. Except to the extent that liability cannot by law be excluded, none of the Company and the Placement Agent or their respective related bodies corporate, or any of their respective directors, officers, employees or advisers accept any responsibility in relation to the Placement or your acquisition of any Placement Shares. You acknowledge that you will accept the decisions and actions of the Placement Agent in respect of the Placement Agreement (as defined in paragraph 7 above) relating to the Placement and your acceptance of the Offer does not oblige the Placement Agent to consult with you as to any matter or qualify the exercise or non-exercise of the rights of the Placement Agent under the Placement Agreement in any way, including in particular, the exercise of the right of termination. You acknowledge that any issue of Placement Shares to you pursuant to your acceptance of theOffer is subject to the completion of the Placement Agreement relating to the Placement in accordance with its provisions. You acknowledge that the share price of the Company may rise and fall prior to you being issued shares in the Company but that this agreement remains binding on you. You acknowledge that the Placement Agent may scale back your allocation in the event that the Placement is oversubscribed. The representations and warranties made by you are true and correct as at the date of the Placement Acceptance Advice and will be true and correct as at the date of allotment of the Placement Shares. Once you have completed the Placement Acceptance Advice, if you fail to meet any obligation to procure Placement Shares in the Global Offers by the time required by this agreement, the Placement Agent may require that you do so or may without notice to you itself (or procure for a third party to) procure those Placement Shares. In addition to any other obligations under this agreement you indemnify the Placement Agent for any cost or loss associated with so doing (including loss incurred on the sale of the Placement Shares within 6 months of the procurement). The Company and the Placement Agent and their respective directors, officers, employees and advisers will rely upon the truth and accuracy of your acknowledgments, representations, warranties and Governing Law and Jurisdiction The agreement between us arising out of your irrevocable acceptance of the terms of the Offer shall be governed by the laws of New South Wales, Australia and if you accept the Offer you will be and remain obliged to submit to the non-exclusive jurisdiction and determination of the courts of that State. Confidential Information

$P$ 7

NO. 4531

  1. NOV. 2005 14:17

WILSON HTM 61 2 8247 6601

You agree to treat any information provided to you in relation to the Company, the Placement Agent and the Placement as strictly confidential and not to disclose it to any other person. Such information is being made available to you solely in connection with your consideration of the Offer of Placement Shares, You further agree that you will not purchase or sell any shares of any type in the Company or procure another berson to do so, in breach of Part 7.10 of the Act.

17. Entire Agreement

The terms contained in this Placement Offer Letter including, without limitation, your duly executed and delivered Placement Acceptance Advice, constitute the entire terms of the agreement between the Company, the Placement Agent and you as to the Placement of the Placement Shares offered to you and your participation in the Placement to the exclusion of all prior representations, understandings and agreements between the Company or the Placement Agent and you. Any variation of the terms of the agreement must be in writing signed by each of the Company, the Placement Agent and you.

13. Notices

Any notice to be given relating to the Offer of Placement Shares or your acceptance of the Offer may be sent by facsimile to the facsimile number of the party to whom the notice is sent and will be deemed to have been given upon the successful transmission to that facsimile number.

14. Placement Acceptance Advice

Each applicant for Placement Shares will be required to execute and deliver a Placement Acceptance Advice (attached) which incorporates by reference the representations, warranties and agreements set out in this Placement Offer Letter.

Our receipt of your Placement Acceptance Advice signed by you will constitute your unconditional and irrevocable acceptance of the Offer set out in this Placement Offer Letter. Placement Shares will not be attocated or issued to you if you fail to execute and deliver to the Placement Agent the Placement Acceptance Advice in the form attached.

To confirm your irrevocable acceptance of the terms of the Placement and entry into an agreement with the Placement Agent for the acquisition of the Placement Shares indicated in this Placement Offer Letter, please sign and return a fully completed, executed and dated copy of the Placement Acceptance Advice to the Placement Agent by fax on or before 5PM Sydney time, Monday 7th November 2005 to:

Attention: Lisa Springer, Wilson HTM Limited; Facsimile: (61-2) 8247 6621;

15. Settlement

Settlement of the institutional portion of the Offer is to be conducted by the Placement Agent via the CHESS Delivery versus Payment (DVP) settlement service, and is scheduled to occur on 11th November 2005 (the interventy recover regiment year, accounting an intervention is seriously as security in the intervention and the"Settlement Date"). The Placement Agent has provided all successful institutional allottees with a GARD Form

You are required to advise the Placement Agent of your booking details in the usual manner by no later than SPM (Sydney time) Monday 7th November 2005.

Prior to the Settlement Date (preferably immediately), we require your appointed settlement agent totransmit a Dual Entry Batch Message (as defined in the SCH Business Rules) with the Placement Agent to facilitate settlement of the transaction by DvP Settlement in accordance with the SCH Business Rules. You should instruct your settling Custodian to settle with Wilson HTM (PID 04124) on Friday 11th November 2005 via CHESS message type "101" DvP with a Transaction basis of "I" (IPO) and a stock code of "PXS" quoting Bid Reference Number "PXS23"

Yours sincerely Lisa Springer Business Director Wilson HTM Limited

$\sim 10^4$

ستعمل والمر

$-7-$
PLACEMENT ACCEPTANCE ADVICE PHARMAXIS LIMITED ("PXS")
Private & Confidential
To:Attention: Ms Lisa SpringerFacsimile No: (02) 8247 6621 Wilson HTM Corporate Finance Limited Code: PXS23
Letter") regarding the placement by the Company of 19,900,000 Placement Shares. We refer to the Placement Offer Letter from the Placement Agent dated 7 th November 2005 (the "Offer
terms and conditions set out in the Offer Letter: We confirm our unconditional and irrevocable agreement to subscribe for the following allocation on the
Placement Shares at $2.20 per share: 3,500,000 Shares
Application Monies: A$7,700,000
Full Name of Applicant: ORSIS ANDESTIMENT MINNAGEMENT NM ITE
Address of Applicant: 34 BERMUSHNA RD.
NAMILION HM II
Name of Contact: STEJEN TIMBNÉLL
Telephone: +1-7-41 296 5000 225 Fax Number? 1 - 441 296 300 /
Sfenature: Date: T NO UFMAR 2005
Details of authorised signatory:
STEVEN TIM AREALName ASIAN TRADER MANI INSTANTINGSMANAGFAR A KINTIFI)rganisation