SYNTARA LIMITED — Director's Dealing 2006

Mar 20, 2006

Appendix 3Z

Rule 3.19A.3

Final Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

	Name of entity PHARMAXIS LTD
IA BN75 082 811 630

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	Brett Charlton
Date of last notice	1 February 2006
Date that director ceased to be director	20 March 2006

Part 1 - Director's relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Number & class of securities

660,000 Ordinary shares in Pharmaxis Ltd 1,065,000 unlisted options over ordinary shares issued under the Pharmaxis Ltd Employee Option Plan

$+$ See chapter 19 for defined terms.

Part 2 - Director's relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interestNote: Provide details of the circumstances giving rise tothe relevant interest	Number & class of securities
N/A

Part 3 – Director's interests in contracts

Detail of contract	N/A
Nature of interest
Name of registered holder(if issued securities)
No. and class of securities towhich interest relates

$+$ See chapter 19 for defined terms.