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Swedish Orphan Biovitrum Earnings Release 2011

Feb 23, 2012

2974_10-k_2012-02-23_3e846cc5-2739-4d1c-8c1c-c15f8e996b17.pdf

Earnings Release

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Report for the Fourth Quarter and Full Year 2011

Stockholm, 23 February 2012

Geoffrey McDonough, CEO: "2011 was a year of consolidation and stabilization for Sobi. Our full year results show revenues in line with the previous year, with impact from currency and discontinued products balanced by growth in our product portfolio and the ReFacto® manufacturing business. During the year, we expanded geographically, reduced our cost base and decreased our net debt. In order to improve operational efficiency, we are implementing a new organization and reporting structure based on the three business lines: Core Products, Partner Products, and ReFacto® manufacturing and royalty. We enter 2012 focused on the operating performance and growth of our business lines, and on achieving the key milestones in our pipeline in the second half of the year."

Fourth quarter1)

  • Total revenues as reported declined by 6% to SEK 436.4 M (465.0), and were unchanged adjusted for currency effects and discontinued products.
  • Product revenues rose by 11% adjusted for currency effects and discontinued products.
  • Gross margin declined to 64.9% (67.4), primarily due to lower manufacturing revenues. Gross margin improved from the third quarter mainly as a result of higher plant utilization.
  • Write-down of balance sheet items affecting EBIT by SEK 291.4 M.

Full year 20111)

  • Total revenues as reported were unchanged at SEK 1,910.8 M (1,906.7), but increased by 9% adjusted for currency effects and discontinued products.
  • Product revenues increased by 8% adjusted for currency effects and discontinued products.
  • Revenues from ReFacto® manufacturing and royalty increased by 16% to SEK 575 M.
  • Gross margin declined to 56.4% (64.0) mainly due to a lower margin for manufacturing and currency effects.
  • Operating expenses declined by 6% reflecting the ongoing streamlining of operations.

Significant events after reporting period

  • Extension of supply agreement with Pfizer for ReFacto®/XYNTHA® until 2020.
  • Agreement with Pfizer to return co-promotion rights in exchange for a payment of USD 47.5 M.

Outlook for 2012

Total revenues for the full year 2012 are expected to be approximately SEK 100 M lower than 2011 reflecting the divestment of the ReFacto® co-promotion rights. Gross margin expected to be in line with 2011, which was 54% after adjustment for both the balance sheet write-downs and copromotion, see page 8.

Q 4
2011 adjusted for 2011 adjusted for
Amounts in SEK million 2011 write downs 2010 2011 write downs 2010
Total revenues 436.4 436.4 465.0 1.910.8 1,910.8 1,906.7
Gross profit 180.3 283.4 313.2 974.6 1.077.8 1,221.0
Gross margin 41.3% 64.9% 67.4% 51.0% 56.4% 64.0%
Operating profit before amortizations and non-recurring items (EBITA) $-115.8$ 38.6 199.0 127.3 281.8 378.7
Operating profit before non-recurring items (EBIT) $-317.1$ $-25.8$ 53.2 $-238.2$ 53.2 77.5
Profit/loss 11.8 303.2 $-13.2$ 17.9 309.3 $-104.4$
Earnings/loss per share, SEK 2) 0.04 1.14 $-0.06$ 0.07 1.28 $-0.47$

1) Adjusted for balance sheet write-downs in Q4 2011.

2) Comparison numbers adjusted for the rights issue completed in June 2011.

Fourth quarter Revenues and profit

Total revenues declined by 6% to SEK 436.4 M as compared to SEK 465.0 M in the fourth quarter of 2010. Adjusted for negative currency effects of SEK 1.9 M and discontinued products in the amount of SEK 24.9 M, revenues in the quarter were unchanged from the previous year. Discontinued products comprise the Shire products (Xagrid®, Fosrenol®, Equasym®) and Mimpara®.

Product revenues, including co-promotion but excluding manufacturing and royalty revenues for ReFacto®, adjusted for currency effects and discontinued products, rose by 11% as a result of positive trends for most products. Manufacturing revenues for ReFacto® declined in comparison with a strong quarter in 2010.

Gross margin, adjusted for balance sheet write-downs declined to 64.9% (67.4), mainly due to lower manufacturing revenues. Gross margin improved compared to the third quarter mainly due to higher plant utilization.

Operating expenses 1) , declined by 3%, reflecting the ongoing streamlining of operations.

Operating profit (EBITA) before write-downs, amortization of intangible assets and non-recurring items, was SEK 38.6 M (199.0). The decline reflects lower revenues and contribution from ReFacto® in 2011 and proceeds from the sales of Mimpara® in 2010. The operating loss/profit (EBIT) before write-downs and non-recurring items was SEK -25.8 M (53.2). Amortization of intangible assets amounted to SEK 67.0 M (145.8).

Write-down of balance sheet items

As previously communicated, a number of balance sheet items were written down in the fourth quarter. These items amounted to a total of SEK 291.4 M.

Item SEK M
Inventory (Kineret® and Kepivance®) 103.2 Gross profit
Overdue trade receivables 14.8 Operating expenses
Intangibles (Leptin modulation program) 126.9
Real estate 46.5
Total 291.4 Operating profit before non-recurring (EBIT)

Non-recurring items

Non-recurring items in the fourth quarter amounted to SEK -10.6 M (-29.8) and consisted mainly of costs related to the consolidation of headquarters office space following the headcount reductions implemented during the year.

Financial items and tax

_____________________________

Net financial items for the fourth quarter amounted to SEK -19.1 M (-26.6). The improvement is due to the reduction in net debt following the rights issue in the second quarter.

Sobi has valued its tax loss carry forwards in the quarter. The company's tax rate therefore deviates from the Swedish tax rate. The current tax expense for the quarter was SEK -2.0 M (-4.1) and deferred tax amounted to SEK 360.6 M (-5.9) providing a positive net effect on the results of SEK 358.6 M (-10.0).

The profit for the period amounted to SEK 11.8 M (-13.2), corresponding to SEK 0.04 (-0.06) per share.

1) Excluding amortization of intangible assets, non-recurring items, other operating revenues and expenses, and adjusted for balance sheet write-downs.

Full year 2011

Revenues and profit

Total revenues for the full year of 2011 amounted to SEK 1,910.8 M (1,906.7). Adjusted for negative currency effects of SEK 87.8 M and discontinued products in the amount of SEK 73.3 M, total revenues increased by 9%.

Product revenues, including co-promotion but excluding manufacturing and royalty revenues for ReFacto®, rose by 8% adjusted for currency effects and discontinued products. Revenue from ReFacto® manufacturing and royalty rose by 16%.

Gross margin, adjusted for balance sheet write-downs, was 56.4% as compared to 64.0% in the previous year. The decline was mainly due to an overall lower margin for manufacturing revenues as a result of the structure of the agreement with Pfizer. Negative currency effects and the cost for transferring production of Kineret® also had an impact. The gross profit for the previous year included SEK 22.7 M in contribution from Mimpara® copromotion and a milestone payment of SEK 23.5 M related to the Syntonix transaction that was received in the first quarter of 2010.

Other operating revenues and expenses, adjusted for balance sheet write-downs, amounted to SEK 148.9 M and includes SEK 149.2 M referring to the agreement regarding Multiferon® with the previous owners of Swedish Orphan, which resulted in the release of the previously booked provision for the additional purchase consideration in the second quarter. Other operating revenues and expenses in the previous year include the proceeds for Mimpara® which was divested in the fourth quarter.

Operating expenses1) declined by 6% to SEK 945 M. The reduction is mainly due to the cost-saving activities that were implemented during 2010 and 2011. Total expenses for R&D declined despite higher investment in the Kiobrina® phase III program.

Operating profit (EBITA) before write-downs, amortization of intangible assets and non-recurring items, was SEK 281.8 M (378.7). Amortization of intangible assets amounted to SEK 231.2 M (301.2). Operating profit (EBIT) before write-downs and non-recurring items was SEK 53.2 M (77.5).

Non-recurring items

Non-recurring items amounted to SEK 80.4 M and consisted mainly of severance pay and other costs related to the reduction of about 60 positions that was decided in March 2011. The savings from these measures are estimated at approximately SEK 90 M annually and are expected to have full effect as of 2012. Non-recurring items for the previous year amounted to SEK 87.7 M and referred mainly to severance pay and other expenses in connection with the acquisition of Swedish Orphan.

Financial items and tax

Net financial items for the full year of 2011 amounted to SEK -52.2 M (-82.2). The financial net in the previous year included a write-down of SEK 19 M on a non-performing loan. The financial expense is mainly related to the company's net debt which was reduced substantially following the rights issue in the second quarter.

Sobi has valued its tax loss carry forwards. The company's tax rate therefore deviates from the Swedish tax rate. The current tax expense for the full year was SEK -5.9 M (-38.5) and deferred tax amounted to SEK 394.7 M (26.5) providing a positive net effect on the results of SEK 388.8 M (-12.0).

Profit for the period, excluding write downs was SEK 309.3 M (-104.4). The profit for the period including writedowns amounted to SEK 17.9 M (104.4), corresponding to earnings per share of SEK 0.07 (-0.47).

1) Excluding amortization of intangible assets, non-recurring items, other operating revenues and expenses, and adjusted for balance sheet write-downs.

Revenues by region and key products

Product revenues, including co-promotion but excluding manufacturing and royalty revenues for ReFacto®, declined for the full year by 4% to SEK 1,335.8 M (1,385.4). Adjusted for negative currency effects of SEK 76.3 M and discontinued products amounting to SEK 73.3 M, revenues increased by 8%. Product revenues for the fourth quarter increased by 1% to SEK 330.1 M (326.2). Adjusted for negative currency effects of SEK 1.8 M and discontinued products amounting to SEK 24.9 M, revenues in the quarter increased by 11%.

Product revenues by region

Sales in the Nordic region declined for the full year by 5% to SEK 427.9 M (450.4), as a result of the expiry of the contract regarding the Shire products, Mimpara® and Tracleer®. After adjustments for negative currency effects of SEK 9.2 M SEK and discontinued products in the amount of SEK 73.3 M, sales in the Nordic region increased by 18%. Sales in the fourth quarter, after adjustment for currency effects and discontinued products, rose by 34%, as a result of positive trends for most products.

Sales in the rest of Europe for the full year declined by 2% to SEK 540.9 M (551.3), but rose by 3% after adjustment for currency effects. Sales in the rest of Europe during the fourth quarter were unchanged and amounted to 140.7 M (140.5).

Sales in North America for the full year declined by 4% to SEK 328.2 M (340.2), but increased by 8% adjusted for currency effects. Sales in North America in the fourth quarter increased by 13% in SEK and by 15% adjusted for currency effects.

Product revenues by region

(Excluding ReFacto® manufacturing and royalty revenues)

Q4 Full year
Amounts in SEK million 2011 2010 Change 2011 2010 Change
Nordic 102.2 103.0 $-1\%$ 427.9 450.4 $-5%$
Europe 140.7 140.5 0% 540.9 551.3 $-2%$
North America 78.3 69.0 13% 328.2 340.2 $-4%$
RoW 9.0 13.7 $-34%$ 38.8 43.5 $-11\%$
Total revenues 330.1 326.2 1% 1,335.8 1,385.4 -4%

Revenues by key product

ReFacto®

Total revenues, i.e. from manufacturing, co-promotion and royalty, for the full year 2011 increased by 15% to SEK 672.3 M (587.1). Total revenues in the fourth quarter declined by 17% due to lower manufacturing revenues, as compared with a strong fourth quarter in 2010.

Kineret®

Sales for the full year were unchanged at SEK 422.0 M (422.3), but increased by 8% after adjustment for currency effects. Sales in the fourth quarter rose by 8% as reported and by 9% adjusted for currency effects on the basis of good volume growth, especially in Europe.

As previously announced, the transfer of Kineret® production from Amgen Inc. in the US to a contract manufacturer in Europe has been delayed due to technical issues. Final process validation runs are scheduled to be completed in the second quarter of 2012.

Orfadin®

Sales for the full year declined by 2% to SEK 315.7 M (321.8), but increased by 5% adjusted for currency effects. Sales for the quarter rose 1% adjusted for currency. The result for the fourth quarter was adversely affected by significant Medicaid rebates in the US.

Sales of Orfadin® in Russia increased in the quarter with the establishment of reimbursement for the first HT-1 patients. The positive trend is expected to continue as new legislation will come into effect during 2012 granting all HT-1 patients reimbursement for treatment with Orfadin®.

Kepivance®

Sales for the full year declined by 18% to SEK 77.9 M (94.8), and by 9% after adjustment for currency effects. Sales in the fourth quarter rose by 14%, both as reported and adjusted for currency. Sales for this product showed growth in both the third and fourth quarter after a continuous negative trend since the restriction of the European label became effective in early 2010. The increase was mainly driven by the US, but several European markets also reported higher sales.

Yondelis®

Sales for the full year increased by 22% to SEK 49.4 M (40.6), and by 26% adjusted for currency effects. Sales in the quarter rose by 7% or by 9% adjusted for currency effects.

Willfact®

Sales for the full year rose by 28% to SEK 16.8 M (13.1) and by 6% for the quarter. The growth refers in particular to the German market and is driven by prophylactic treatment in conjunction with surgery.

Product revenues by key product
--------------------------------- --
Q4 Full year
Amounts in SEK million 2011 2010 Change 2011 2010 Change
ReFacto 130,2 157,5 $-17%$ 672,3 587,1 15%
of which Manufacturing revenues 77.9 119,9 $-35%$ 451.7 388,0 16%
of which Co-promotion 24,0 18,4 30% 97.3 89,4 9%
of which Royalty 28,3 19,2 48% 123,3 109,7 12%
Kineret 109,3 101,3 8% 422,0 422,3 0%
Orfadin 74,2 75,0 $-1%$ 315,7 321,8 $-2%$
Kepivance 21,0 18,4 14% 77.9 94,8 $-18%$
Ammonaps 16,0 13,6 18% 66,1 69,1 $-4%$
Yondelis 14.4 13,4 7% 49.4 40,6 22%
Willfact 4,7 4,4 6% 16,8 13,1 28%
Other product revenues 66,6 56,8 17% 245.6 216,0 14%
Total revenues continued products 436,4 440,4 $-1%$ 1865.8 1764.8 6%
Discontinued products 0,0 24,9 $-100%$ 45,0 118,3 $-62%$
Other revenues 0,0 $-0,3$ >100% 0,0 23,6 $-100%$
Total revenues 436.4 465,0 $-6%$ 1910,8 1906,7 0%

Cash flow and investments

Cash flow from operations in the full year amounted to 102.9 M (-215.1). Non-cash items amounted to SEK 100.4 M (354.2) and were mainly attributable to valuation of tax loss carry forward, amortization of intangible assets, the write-down of balance sheet items in the fourth quarter, and the effect of the agreement regarding Multiferon®.

An increase in working capital for the full year had a negative impact on cash flow of SEK -15.4 M (-464.8) as reduced inventory levels were offset by somewhat higher receivables.

Cash flow from operations before working capital in the fourth quarter amounted to SEK 29.9 M (SEK 140.9). Cash flow in 2010 was positively impacted by the sale of Mimpara®. Non-cash items amounted to SEK 18.1 M (153.9) and refer mainly to valuation of tax loss carry forward, amortization of intangible assets and the write down of balance sheet items in the quarter.

A decline in working capital in the fourth quarter had a positive impact on cash flow of SEK 105.1 M (-109.1), mainly as a result of lower receivables. Reduced inventory of Kineret had a positive impact compared to 2010 when extra supply was acquired. This was more than offset by increased stock levels of distribution products and of ReFacto® following the high production rate in the quarter. Cash flow from net investments in the fourth quarter amounted to SEK -3.1 M (-48.7).

Financial position

Cash and cash equivalents and short-term investments as of December 31, 2011 amounted to SEK 219.1 M (38.5). The company's financing through bank loans as of December 31, 2011 amounted to SEK 700.0 M (1,201.1).

Equity

Consolidated shareholders' equity as of December 31, 2011 amounted to SEK 4,963.4 M compared to SEK 4,342.4 M as of December 31, 2010.

The rights issue which was finalized at the beginning of June 2011 increased equity by SEK 594 M, net of transaction costs. The rights issue increased the number of shares by 53,045,319 common shares. As of December 31, 2011, the total number of shares was 267,295,132 of which 265,226,598 common shares and 2,068,534 C-shares. All C-shares are held by the company.

Research and development

rFIXFc and rFVIIIFc

Sobi's and Biogen Idec's rFIXFc and rFVIIIFc hemophilia programs are advancing according to plan. The bulk of the patients in the phase III study for rFIXFc (B-LONG) have been enrolled. Enrollment of surgery patients will continue through the first half of the year. Recruitment of patients in the phase III study for rFVIIIFc (A-LONG) is ongoing. Data from both studies are expected during the second half of 2012.

The global pediatric studies KIDS B-LONG and KIDS A-LONG are expected to have the first patients enrolled during the first half of 2012. The pediatric studies are open label, multicenter studies designed to evaluate the safety, pharmacokinetics and efficacy in previously treated hemophilia B or A children below 12 years of age.

Kiobrina®

The first patient was enrolled in the phase III study with Kiobrina® (rhBSSL) at the end of July 2011.

Development pipeline

Indication Product/Project Partner Phase I Phase II Phase III Reg phase
Hemophilia A rFVIIIFc BiogenIdec
Hemophilia B rFIXFc BiogenIdec
Prevent growth restriction in premature infants Kiobrina®
Diuresis and seizures in neonates Reformulated
Bumetanide
Only For Children
Pharmaceuticals (O4CP)
Life cycle management
Indication Product/Project
CAPS Kineret®
Hereditary tyrosinemia type 1 Orfadin®, liquid formulation

Key dates

Activity Expected timing
rFVIIIFc (hemophilia A): report phase III data H2 2012
rFIXFc (hemophilia B): report phase III data H2 2012
Kiobrina® (prevent growth restriction): phase III data 2013

New reporting structure 2012

As of the first quarter 2012, revenues will be reported in the three business lines – Core Products, Partner Products and ReFacto®. The table below shows the figures for 2010 and 2011 restated according to the new structure. See page 14 for quarterly figures.

The figures have been restated to show co-promotion revenues for ReFacto® and BeneFix® on a separate line to facilitate comparison following the sale of these rights to Pfizer as of 15 February 2012.

Restated figures according to the new structure

Full year
Amounts in SEK million 2011 2010
Kineret 422.0 422.3
Orfadin 315.7 321.8
Other core products 74.6 76.8
Core Products 812.3 820.9
Manufacturing revenues 451.7 388.0
Royalty revenues 123.3 109.7
ReFacto AF 575.0 497.7
Current portfolio 373.6 346.0
Discontinued products 45.0 118.3
Co-promotion revenues 105.0 100.3
Partner Products 523.6 564.5
Other revenues 0.0 23.6
Total Revenues 1,910.8 1,906.7

Products per business line

Core Products Partner Products ReFacto®
Inflammation ReFactoAF co-promotion Manufacturing
Kineret Kepivance Royalty
Ruconest Yondelis
Ferriprox
Genetics & Metabolism Betapred
Orfadin Buronil
Ammonaps Aloxi
Ammonul Willfact
Other ( ~40 products)

Outlook for 2012

Market conditions are expected to continue to be challenging, particularly in Europe due to the uncertain macroeconomic environment, and in the US related to the evolution of the new healthcare regime. The outlook is based on the assumption that the current SEK/USD and SEK/EUR exchange rates prevail during the year, and that market conditions do not significantly deteriorate.

Total revenues for the full year 2012 are expected to be approximately SEK 100 M lower than in 2011 reflecting the divestment of the ReFacto®co-promotion rights.

Revenues for Core Products and Partner Products are expected to show mid to high single digit growth, while revenues for ReFacto® manufacturing and royalty are expected to show low single digit growth. Revenues in 2011 from validation batches (SEK 42 M) and discontinued products (SEK 45 M) will not recur in 2012.

The gross margin for the full year 2012 is expected to be in line with the 2011 margin, which was 54% after adjustment for both the balance sheet write-downs and the divestment of co-promotion rights. Costs in 2012 related to the transfer of Kineret® production are estimated at SEK 60 M and are expected to impact the gross margin primarily in the first half of the year. As a result of the renegotiated ReFacto® manufacturing agreement with Pfizer, reduced quarterly variations in the ReFacto® manufacturing gross margin are expected.

Operating expenses, excluding amortizations, are estimated at or below SEK 950 M.

The earlier reported milestone payment to Amgen of USD 55 M is now estimated to become due in Q4 2012 or in Q1 2013, with the ultimate timing dependent on the cumulative sales of Kineret®.

Other information

Change in agreement regarding Multiferon®

An agreement was signed in the second quarter of 2011 regarding the additional purchase consideration for Multiferon® and the hepatitis C clinical study which was included in the agreement with the sellers upon Biovitrum's acquisition of Swedish Orphan in 2009. Under the new agreement the sellers waived the requirements of an additional purchase consideration and implementation of the study in exchange for a onetime payment of SEK 25 M paid out during the third quarter. As a result of the agreement the booked provision for the additional purchase consideration was released in the second quarter and approximately SEK 149 M was included in operating income for that quarter.

Personnel

As of December 31, 2011 the number of full-time employees was 506 (508).

Significant events after the reporting period

Agreement with Pfizer regarding ReFacto®AF/XYNTHA®

Sobi and Pfizer have extended their supply agreement for ReFacto AF®/XYNTHA® until 31 December 2020, with an option to be further renewed. The previous agreement was due to expire in 2015.

In a separate agreement, Sobi and Pfizer also agreed that Sobi would return the co-promotion rights for ReFacto® and BeneFIX® in the Nordic region to Pfizer as of 15 February 2012 in exchange for a payment to Sobi in the amount of USD 47.5 M.

Terms of agreement with Biogen Idec regarding hemophilia programs

Further details on the restructured agreement with Biogen Idec regarding development and commercialization of long-lasting recombinant factor VIII and factor IX hemophilia programs, was disclosed in a press release on 6 February 2012. The press release is available at www.sobi.com.

Licensing agreement for novel neonatology treatment

In January 2012, Sobi signed a global licensing agreement with the French company Only for Children Pharmaceuticals (O4CP) regarding bumetanide reformulated for treatment of diuresis and seizures in neonates. The new drug is currently in clinical phase II under the EU financed NEMO project. The first market authorization of the product is expected in 2014.

O4CP will be responsible for obtaining market authorizations and for the development and manufacture of drug product. Sobi will be accountable for the commercialization of the product on a global basis.

The agreement included an upfront payment by Sobi in the amount of EUR 300 000 and potential future milestones of a value up to approximately EUR 1.7 M. O4CP will also receive royalties on future commercial sales.

Changes in Executive Management

Alan Raffensperger has been appointed Chief Operating Officer (COO) with responsibility for Sales and Marketing, Supply Chain, Procurement and IT. His most recent position was CEO of Benechill Inc., an American medical device company within the therapeutic hypothermia field. Alan Raffensperger holds a Bachelor of Science from University of Maryland, Baltimore, USA.

Wills Hughes-Wilson has been appointed Vice President, Government Affairs & Policy. She will be responsible for Sobi's contacts with all stakeholders in the health policy area. Her most recent position was Vice President Health/Market Access Policy, Europe, within Genzyme Corporation, now part of the French Sanofi Group. Wills Hughes-Wilson holds an Honors graduate in Law from University of Durham in the UK.

Annual General Meeting 2012

The Annual General Meeting of Swedish Orphan Biovitrum AB will be held at 4 p.m. on Thursday, 26 April 2012 in the Wallenberg Auditorium at the Royal Swedish Academy of Engineering Sciences (IVA), Grev Turegatan 16, Stockholm, Sweden.

The Board of Directors proposes that no dividend will be paid for the 2011 financial year.

The Annual Report for 2011 will be published on www.sobi.com three weeks before the AGM. It will also be available at Sobi's headquarters at Tomtebodavägen 23 A in Solna.

Solna, 23 February 2012

Geoffrey McDonough President and CEO

Forward-looking statement

This interim report includes forward-looking statements. Actual results may differ from those stated. Internal factors such as the successful management of research programs and intellectual property rights may affect future results. There are also external conditions such as the economic climate, political changes and competing research programs that may affect Swedish Orphan Biovitrum's results.

This interim report has not been reviewed by the company's auditors.

Financials & Notes

Statement of Comprehensive Income

Q 4 Full year
Amounts in SEK million 2011 before
write down
Write down 2011 2010 2011 before
write down
Write down 2011 2010
Total revenues 436.4 436.4 465.0 1,910.8 1,910.8 1,906.7
Total cost of goods and services sold $-152.9$ $-103.2$ $-256.1$ $-151.8$ $-833.1$ $-103.2$ $-936.3$ $-685.7$
Gross profit 283.4 $-103.2$ 180.3 313.2 1077.8 $-103.2$ 974.6 1,221.0
Sales and Administration expenses 1 $-206.5$ $-59.7$ $-266.2$ $-195.7$ $-744.7$ $-59.7$ $-804.4$ $-746.8$
Research and Development expenses 2) $-104.4$ $-126.9$ $-231.3$ $-203.5$ $-428.8$ $-126.9$ $-555.7$ $-558.7$
Non-recurring items 3) $-10.6$ 0.0 $-10.6$ $-29.8$ $-80.4$ 0.0 $-80.4$ $-87.7$
Other operating revenues/expenses 1.7 $-1.5$ 0.2 139.2 148.9 $-1.5$ 147.4 162.0
Operating profit/loss $-36.4$ $-291.4$ $-327.7$ 23.4 $-27.3$ $-291.4$ $-318.6$ $-10.2$
Financial income/expenses $-19.1$ $-19.1$ $-26.6$ $-52.2$ $-52.2$ $-82.2$
Profit/loss after financial items $-55.4$ $-291.4$ $-346.8$ $-3.2$ $-79.5$ $-291.4$ $-370.8$ $-92.4$
Income tax 358.6 358.6 $-10.0$ 388.8 388.8 $-12.0$
Profit/loss for the period 303.2 $-291.4$ 11.8 $-13.2$ 309.3 $-291.4$ 17.9 $-104.4$
Other comprehensive income 4)
Translation difference 0.0 0.0 $-0.6$ 0.0 0.0 $-1.8$
Comprehensive income for the period 303.2 $-291.4$ 11.8 $-13.8$ 309.3 $-291.4$ 17.9 $-106.2$
Earnings/loss per share after tax (SEK) 5) 1.14 0.04 $-0.06$ 1.28 0.07 $-0.47$
Earnings/loss per share after dilution (SEK) 5) 1.14 0.04 $-0.06$ 1.28 0.07 $-0.47$
1) Amortization and write down of intangible assets included
in Sales & Adm expenses
2) Amortization and write down of intangible assets included
$-63.7$ $-73.7$ $-66.9$ $-227.9$ $-237.9$ $-222.3$
in Research and Development expenses
3) Amortization and write down of intangible assets included
$-0.7$ $-127.6$ $-78.9$ $-0.7$ $-127.6$ $-78.9$
in Non-recurring items $-2.6$ $-2.6$ 0.0 $-2.6$ $-2.6$ 0.0

Balance sheet

Dec 31 Sep 30 Jun 30 Mar 31 Dec 31
Amounts in SEK million 2011 2011 2011 2011 2010
ASSETS
Fixed assets
Intangible fixed assets 1) 4,885.1 5,070.9 5,125.0 5,172.1 5,224.3
Tangible fixed assets 155.9 219.3 230.9 240.4 251.4
Financial fixed assets 11.4 22.7 20.0 20.9 21.8
Total fixed assets 5,052.4 5,312.9 5,375.8 5,433.5 5,497.6
Current assets
Inventories 893.8 953.2 1,008.6 1,001.2 1,070.4
Accounts receivable 309.6 406.8 355.1 361.4 322.6
Current receivables, non-interest bearing 224.6 198.4 236.0 197.8 140.5
Cash and cash equivalents 219.0 73.1 115.0 37.7 38.5
Total current assets 1,647.1 1,631.4 1,714.6 1,598.2 1,572.0
Total assets 6,699.5 6,944.3 7,090.5 7,031.6 7,069.6
EQUITY AND LIABILITIES
Shareholders equity 4,963.4 4,948.3 4,984.1 4,274.4 4,342.4
Long-term liabilities
Long-term debt 700.7 686.1 713.3 1,208.1 1,208.0
Long-term liabilities, non-interest bearing 358.7 730.9 740.7 748.4 762.1
Total long-term liabilities 1,059.4 1,417.0 1,454.0 1,956.5 1,970.0
Current liabilities
Short term debt 13.9 14.0 14.8 203.5 178.6
Current liabilities, non-interest bearing 662.8 565.0 637.6 597.2 578.6
Total short-term liabilities 676.7 579.0 652.4 800.7 757.1
Total equity and liabilities 6,699.5 6,944.3 7,090.5 7,031.6 7,069.6

1) Including goodwill SEK 1,605.3 M (1,601 as per December 31, 2010)

Full year
Amounts in SEK million 2011 2010
Opening balance 4,342.4 1,352.8
Adjustment of acquisition analysis1) -58.8
Opening balance 4,342.4 1,294.0
Sharebased compensation to employees 9.3 8.5
Issue of shares 594.0 3,146.8
Redemption of shares -0.9
Comprehensive income for the period 17.9 -106.2
Equity, end of period 4,963.4 4,342.4

1)As a consequeuence of adopting new accounting principles, IFRS 3, as from January 1, 2010, prepaid expenses related to acquisition in progress as per December 31, 2009, has been charged to equity as an adjustment of opening balances.

Cash Flow Statement

Q4 Full year
Amounts in SEK million 2011 2010 2011 2010
Net result 11,8 $-13,0$ 17,9 $-104,5$
Non-cash items 1) 18,1 153,9 100,4 354,2
Cash flow from operations before change in working capital 29,9 140,9 118,3 249,7
Change in working capital 105,1 $-109,1$ $-15,4$ $-464,8$
Cash flow from operations 135,0 31,8 102,9 $-215,1$
Acquisition of business, net of cash acquired - 0,9 $-29,8$ $-1811,3$
Investment in intangible fixed assets $-1,2$ $-47,3$ $-7,6$ $-80,7$
Investment in tangible fixed assets $-2,3$ $-2,3$ $-7,7$ $-42,1$
Divestment of tangible fixed assets 0,3 1,3
Investment/Divestment of financial assets 1,4
Short-term investments ÷ 48,4
Cash flow from investing activities $-3,2$ $-48,7$ -43,7 $-1884.3$
Loans - Raising/Amortization 13,8 $-163,2$ $-472,4$ 467,7
Issue of shares 594,0 1 4 1 4 , 1
Cash flow from financing activities 13,8 $-163,2$ 121,6 1881,8
Net change in cash 145,6 $-180,1$ 180,8 $-217,6$
Liquid funds at the beginning of the period 73,2 219,1 38,5 258,2
Translation difference in cash flow and liquid funds 0,3 $-0.5$ $-0,2$ $-2,1$
Liquid funds at the end of the period 219,1 38,5 219,1 38,5
Short-term investments
Liquid funds and short-term investments at the end of the period 219,1 38,5 219,1 38,5
1) Depreciations and write down:
Depreciation tangible fixed assets 45.2 11.3 81.8 53.9
Amortization and write down of intangible assets 203.9 145.8 368.1 301.2

Key Ratios and Other Information

Q 4 Full year
Amounts in SEK million 2011 2010 2011 2010
Return on
Shareholders' equity 0.2% $-0.3%$ 0.4% $-3.7%$
Total capital $-4.9%$ 0.2% $-4.5%$ $-0.5%$
Margins
Gross margin 41.3% 67.4% 51.0% 64.0%
EBITDA-margin $-16.2%$ 44.7% 10.9% 22.7%
EBITA-margin $-26.5%$ 42.8% 6.7% 19.9%
EBIT-margin $-75.1%$ 5.0% $-16.7%$ $-0.5%$
Profit margin 2.7% $-2.8%$ 0.9% $-5.5%$
Per share data (SEK)
Shareholders' equity per share 18.7 20.5 18.7 20.5
Shareholders' equity per share after dilution 18.7 20.5 18.7 20.4
Cash flow per share 0.5 $-0.0$ 0.7 $-1.1$
Cash flow per share after dilution 0.5 $-0.0$ 0.7 $-1.1$
Other information
Equity ratio 74.1% 61.4% 74.1% 61.4%
Number of ordinary shares 265,226,598 212,181,279 265,226,598 212, 181, 279
Number of C-shares 2,068,534 2,068,534 2,068,534 2,068,534
Average number of ordinary shares 265,226,598 212,181,279 242,119,185 198,741,374
Outstanding warrants 1) 300,000 315,000 300,000 315,000
Number of ordinary shares after dilution 265,226,598 212,804,979 265,226,598 212,804,979
Average number of ordinary shares after dilution 265,226,598 212,804,979 242,119,185 199,371,494

Return on shareholders' equity

Profit after tax as a percentage of average shareholders' equity.

Return on total capital

Profit after financial items plus financial expenses as a percentage of average total assets.

Gross margin Gross profit as a percentage of net sales.

EBITDA margin

Operating profit/loss before extraordinary items plus amortization and impairment in relation to sales.

EBITA margin Operating profit/loss before extraordinary items plus depreciation in relation to sales.

EBIT margin Operating profit/loss in relation to net sales.

Profit margin Net profit for the period in relation to sales.

Shareholders' equity per share Shareholders' equity divided by the number of shares. Shareholders' equity per share after dilution Shareholders' equity divided by the number of shares after dilution.

Cash flow per share Changes in cash and cash equivalents divided by the weighted average number of outstanding shares.

Cash flow per share after dilution Changes in cash and cash equivalents divided by the weighted average number of shares after dilution.

Equity ratio Shareholders' equity as a proportion of total assets.

Extraordinary items

Extraordinary items are defined as transactions of nonrecurring nature, mainly referring to discontinued products and/or operations.

Quarterly data, SEK M

FY FY
Amounts in SEK million $Q1-10$ $Q2-10$ $Q3-10$ $Q4-10$ 2010 $Q1 - 11$ $Q2 - 11$ $Q3 - 11$ $Q4-11$ 2011
Total Revenues 488.1 509.6 444.0 465.0 1,906.7 537.4 490.0 447.1 436.4 1,910.8
COGS $-175.0$ $-200.1$ $-158.8$ $-151.8$ $-685.7$ $-253.5$ $-213.5$ $-213.1$ $-152.9$ $-833.1$
Gross profit 313.1 309.5 285.2 313.2 1,221.0 283.9 276.4 233.9 283.4 1,077.8
Gross margin 64% 61% 64% 67% 64% 53% 56% 52% 65% 56%
Sales and administration expenses $-128.5$ $-145.1$ $-122.1$ $-128.8$ $-524.5$ $-116.7$ $-126.9$ $-130.4$ $-142.8$ $-516.8$
Research and development expenses $-127.7$ $-113.4$ $-114.1$ $-124.6$ $-479.8$ $-102.4$ $-124.6$ $-97.3$ $-103.7$ $-428.1$
OPEX $-256.2$ $-258.5$ $-236.2$ $-253.4$ $-1,004.3$ $-219.2$ $-251.5$ $-227.7$ $-246.5$ $-944.9$
% of sales $-52%$ $-51%$ $-53%$ $-54%$ $-53%$ $-41%$ $-51%$ $-51%$ $-56%$ -49%
Other operating revenues/expenses $-1.7$ 7.9 16.7 139.2 162.0 $-5.0$ 155.4 $-3.2$ 1.7 148.9
EBITA before non-recurring items 55.1 58.9 65.6 199.0 378.7 59.7 180.4 3.0 38.6 281.8
% of sales 11% 12% 15% 43% 20% 11% 37% 1% 9% 15%
Non-recurring items $-47.0$ $-4.6$ $-6.3$ $-29.8$ $-87.7$ $-70.1$ 0.0 0.3 $-8.0$ $-77.8$
EBITA 8.1 54.3 59.4 169.2 291.0 $-10.3$ 180.4 3.3 30.6 204.0
% of sales 2% 11% 13% 36% 15% $-2%$ 37% 1% 7% 11%
Amortizations $-51.5$ $-49.8$ $-54.1$ $-145.8$ $-301.2$ $-53.4$ $-53.1$ $-57.7$ $-67.0$ $-231.2$
EBIT $-43.4$ 4.5 5.3 23.4 $-10.2$ $-63.7$ 127.3 $-54.4$ $-36.4$ $-27.2$
EBIT margin $-9%$ 1% 1% 5% $-1%$ $-12%$ 26% $-12%$ $-8%$ $-1%$

Revenues per business line

(Restated as per new structure)

FY FY
Amounts in SEK million $Q1-10$ $Q2-10$ $Q3-10$ $Q4-10$ 2010 $Q1 - 11$ $Q2-11$ $Q3 - 11$ $Q4-11$ 2011
Kineret 104.6 113.0 103.4 101.3 422.3 107.2 102.9 102.5 109.3 422.0
Orfadin 83.1 79.3 84.4 75.0 321.8 76.0 85.2 80.2 74.2 315.7
Other core products 21.1 17.6 20.4 17.7 76.8 17.2 18.7 19.0 19.8 74.6
Core Products 208.8 209.8 208.2 194.0 820.9 200.4 206.8 201.7 203.3 812.3
Manufacturing revenues 73.4 117.5 77.2 119.9 388.0 166.4 108.5 98.9 77.9 451.7
Royalty revenues 29.5 37.3 23.7 19.2 109.7 38.9 36.3 19.7 28.3 123.3
ReFacto AF ® 102.9 154.8 100.9 139.1 497.7 205.3 144.8 118.6 106.2 575.0
Current portfolio 92.2 89.4 77.5 86.8 346.0 80.8 95.3 96.7 100.8 373.6
Discontinued products 32.8 30.5 30.1 24.9 118.3 22.5 17.1 5.4 0.0 45.0
Co-promotion revenues 27.9 25.1 26.9 20.4 100.3 28.3 26.2 24.5 26.0 105.0
Partner Products 152.9 145.0 134.5 132.2 564.5 131.6 138.5 126.6 126.8 523.6
Other revenues 23.5 0.0 0.4 $-0.3$ 23.6 0.1 $-0.3$ 0.1 0.0 0.0
Total Revenues 488.1 509.6 444.0 465.0 1,906.7 537.4 490.0 447.1 436.4 1,910.8

Profit and Loss Statement – Parent Company

Q 4 Full year
Amounts in SEK million 2011 2010 2011 2010
Total revenues 247.7 290.5 1,170.1 1,185.9
Total cost of goods and services sold $-185.4$ $-85.4$ $-647.2$ $-410.8$
Gross profit 62.3 205.1 522.9 775.1
Sales and Administration expenses 1) $-138.4$ $-112.3$ $-380.1$ $-356.9$
Research and Development expenses 2) $-229.0$ $-192.1$ $-534.7$ $-528.6$
Non-recurring items $-57.0$ $-29.4$ $-77.9$ $-81.4$
Other operating revenues/expenses 991.2 139.7 993.1 174.8
Operating profit/loss 629.1 11.0 523.3 $-17.0$
Result from participation in Group companies $-0.3$ $-0.5$ $-6.2$
Financial income $-0.7$ $-2.2$ 11.1 0.0
Financial expenses $-15.8$ $-14.6$ $-65.0$ $-81.4$
Profit/loss after financial items 612.2 $-5.8$ 468.8 $-104.6$
Income tax 77.4 77.4
Profit/loss for the period 689.6 $-5.8$ 546.2 $-104.6$
1) Amortization and write down of intangible assets in Sales &
Adm expenses $-23.8$ $-11.2$ $-62.9$ $-48.7$
2) Amortization and write down of intangible assets included
in Research and Development expenses $-127.6$ $-78.9$ $-127.6$ $-78.9$

Balance Sheet – Parent Company

Dec 31 Sep 30 Jun 30 Mar 31 Dec 31
Amounts in SEK million 2011 2011 2011 2011 2010
ASSETS
Fixed assets
Intangible fixed assets 665.9 799.1 810.8 821.7 833.4
Tangible fixed assets 143.5 207.0 218.3 227.2 237.1
Financial fixed assets 4,156.9 4,275.2 4,269.7 4,414.6 4,414.6
Total fixed assets 4,966.3 5,281.3 5,298.8 5,463.5 5,485.2
Current assets
Inventories 716.8 799.5 860.8 844.7 927.5
Current receivables, non-interest bearing 1,101.6 471.0 403.2 419.4 266.5
Cash and cash equivalents 175.0 44.7 82.3 4.0 9.1
Total current assets 1,993.5 1,315.2 1,346.3 1,268.1 1,203.1
Total assets 6,959.8 6,596.5 6,645.1 6,731.6 6,688.2
EQUITY AND LIABILITIES
Shareholders' equity 5,530.0 4,832.3 4,893.5 4,363.6 4,375.9
Long-term liabilities
Long-term debt 700.0 685.7 699.7 1,194.0 1,193.6
Total long-term liabilities 700.0 685.7 699.7 1,194.0 1,193.6
Current liabilities
Short term debt 223.0 164.3
Current liabilities, non-interest bearing 729.8 1,078.5 1,051.9 951.0 954.5
Total short-term liabilities 729.8 1,078.5 1,051.9 1,174.0 1,118.8
Total equity and liabilities 6,959.8 6,596.5 6,645.1 6,731.6 6,688.2

Change in Shareholder's Equity – Parent Company

Full year
Amounts in SEK million 2011 2010
Opening balance 4,375.9 1,326.1
Sharebased compensation to employees 9.3 8.5
Issue of shares 594.0 3,146.8
Redemption of shares $-0.9$
Merger capital gain 4.5
Exchange rate difference
Comprehensive income for the period 546.2 $-104.6$
Equity, end of period 5,530.0 4,375.9

Notes

Note 1 Accounting and valuation principles and other information

Important accounting principles

Swedish Orphan Biovitrum AB (publ) prepares its consolidated financial statements in accordance with the Annual Accounts Act, the Swedish Financial Reporting Board's recommendation RFR 1. Supplementary Accounting Rules for Groups, and the International Financial Reporting Standards (IFRS) and IFRIC interpretations as adopted by the EU. The consolidated financial statements have been prepared according to the historical cost convention except in the case of financial assets and financial assets and liabilities (including derivative instruments) measured at fair value through profit and loss.

This interim report has been prepared in accordance with IAS 34, Interim Financial Reporting.

Accounting principles applied are in accordance with those described in the Annual Report 2010. More detailed information about the Group's accounting- and valuation principles can be found in the Annual Report 2010 which is available at www.sobi.com.

Operating risks

All business operations involve risk. Managed risk-taking is necessary to maintain good profitability. Risk may be due to events in the external environment and may affect a certain industry or market. Risk may also be specific to a certain company. Swedish Orphan Biovitrum is exposed to three main risk categories:

  • External risks such as patent infringements and competition within product concepts and decisions by authorities regarding product use and prices.
  • Operational risk, e.g. the fact that developing a new drug is both capital-intensive and risky, dependence on external partners in various collaborations, product liability claims, as well as laws and rules on the treatment of hazardous materials
  • Financial risks, such as currency risk, interest risk, credit risk and liquidity risk

A more detailed description of the Group's risk exposure and risk management is included in Swedish Orphan Biovitrum's 2010 Annual Report (see the Directors' Report).

Note 2 Shares and Warrants

Share capital,
Development in share capital and number No of shares SEK
December 2010 214,249,813 117,558,200
June 2011 Rights issue 53,045,319 29,105,800
December 2011 267,295,132 146,664,000

A preferential new share issue was completed in June, 2011, after which the total number of shares are 267,295,132. Issued shares break down as 265,226,598 ordinary shares and 2,068,534 C shares. The ordinary shares carry one vote per share and the C shares carry 1/10 vote per shares. All C shares are treasury shares.

A preferential new share issue was completed in June, 2011, after which the total number of shares are 267,295,132. Issued shares break down as 265,226,598 ordinary shares and 2,068,534 C shares. The ordinary shares carry one vote per share and the C shares carry 1/10 vote per shares. All C shares are treasury shares.

Option and share based incentive programs

Share based incentive program 2008

Plan 2008 program expired on 25 November 2011. No shares were awarded under this program.

Share based incentive program 2009

A long-term, performance based incentive program was adopted ("Share program 2009") at the Annual General Meeting on 28 April 2009. Share program 2009 covers management and key individuals in Swedish Orphan Biovitrum, and may involve a total maximum allocation of 307,601 shares in Swedish Orphan Biovitrum AB (publ). Like in the Share program 2008, the number of shares to be received by program participants, will be based on the development of the Swedish Orphan Biovitrum share over a three-year assessment period. The program was implemented in June 2009, and the assessment period will run from 10 June, 2009 up to and including 9 June 2012.

Share based incentive program 2010

A long-term, performance-based share program ("Share Program 2010") was adopted at the Annual General Meeting on 27 April 2010. Share Program 2010 covers management and key individuals in Swedish Orphan Biovitrum, and may involve a total maximum allocation of 526,242 shares in Swedish Orphan Biovitrum AB (publ). The program is designed to allow the participant to invest in a number of shares and receive the equivalent number of shares free of charge if the individual stays with the company for three years. Employees also have the opportunity to receive additional shares based on Swedish Orphan Biovitrum's performance over a three-year benchmark period. The program was implemented in December 2010 and the benchmark period extends from 13 December 2010, through 12 December 2013.

Share based incentive program 2011

A new long-term, performance-based share program ("Share Program 2011") was adopted at the Annual General Meeting on 28 April 2011. Share Program 2011 covers management and key individuals in Swedish Orphan Biovitrum, and may involve a total maximum allocation of 608,283 shares in Swedish Orphan Biovitrum AB (publ). The program is designed to allow the participant to invest in a number of shares and receive the equivalent number of shares free of charge if the individual stays with the company for three years. Employees also have the opportunity to receive additional shares based on Swedish Orphan Biovitrum's performance over a three-year benchmark period. The program was implemented in December 2011 and the benchmark period extends from 15 December 2011, through 15 December 2014.

Share program for CEO 2011

The Extraordinary General Meeting held on 24 August 2011, adopted a performance based, long-term share program for the CEO Geoffrey McDonough (the "CEO Share Program 2011"). The program is based on an own investment in shares in the market, to be held during a three-year period, and the allotment of performance shares free of charge based on an increase in Swedish Orphan Biovitrum's share price during the performance period ending on 15 August 2014. A maximum number of 500,000 performance shares can be allotted as follows:

Pro-rata allotment of 400,000 performance shares

For any allotment of performance shares to be possible, the share price at the end of the performance period shall amount to more than SEK 25.77. If the share price at the end of the performance period amounts to at least SEK 45.00, 400,000 performance shares will be allotted. If the share price is between SEK 25.77 and SEK 45.00 at the end of the performance period, the portion of the 400,000 performance shares to be allotted shall be calculated on a pro-rata basis.

Threshold allotment 1 of 30,000 performance shares

In addition to the Pro-rata allotment, 30,000 performance shares will be allotted if the share price at the end of the performance period amounts to at least SEK 30.00

Threshold allotment 2 of 70,000 performance shares

In addition to the Pro-rata allotment and the Threshold allotment 1, 70,000 performance shares will be allotted if the share price at the end of the performance period amounts to at least SEK 35.00 .

Warrant programs

Option program 2006/2011 Full year
2011
Full year
2010
Outstanding January 1 15,000 35,000
Forfeited during the period -15,000 -20,000
Outstanding at of end of accounting period - 15,000
Exercisable at of end of accounting period - 15,000
Full year Full year
Employee option program 2007/2012 2011 2010
Outstanding January 1 300,000 300,000
Outstanding at of end of accounting period 300,000 300,000
Exercisable at of end of accounting period 300,000 300,000

Note 3 Transactions with related parties

Full year Full year
Amounts in SEK thousands 2011 2010
Loan to executive management in parent company:
At beginning of the year: 153 153
Loans paid during the year: -153
0 153

The loan to related parties was paid during the period. At the end of the accounting period there are no outstanding loans to related parties.

A company related to the Chairman of the Board, Orfacare Consulting GmbH, provides consultation as regards marketing of drugs for the Sobi group in e.g. Switzerland and Austria, Slovenia and Ex-Yugoslavia. The costs for the year amount to SEK 4.1 M.

Note 4 Contingencies

In 2004, the real estate designated as Paradiset 14 was transferred to a substantially foreign-owned limited liability partnership, called Nya Paradiset KB, whereupon the participating interests in Nya Paradiset KB were sold to an external party, at market price. The real estate was transferred to Nya Paradiset KB, in accordance with the rules regarding so-called transfers below market value, in return for consideration equivalent to the real estate's value for tax purposes. In a submission to the county administrative court, dated 17 April 2008, the Swedish Tax Agency has formally requested that, pursuant the Swedish Tax Avoidance Act, the rules regarding transfers below market value shall not be applied. In the opinion of the Tax Agency, this entails that Swedish Orphan Biovitrum shall be charged a capital gain of SEK 234.5 M, as a consequence of the transfer of the real estate to Nya Paradiset KB. In Swedish Orphan Biovitrum's view, it is patently obvious that the company has not acted in contravention of the purpose of the legislation, in the manner alleged by the Tax Agency in the aforementioned submission. Thereafter, on 9 October 2009, the Tax Agency lodged a new submission and, in reliance on two judgments from the Supreme Administrative Court dated 29 May 2009, has now alleged a new ground, as to why the rules governing transfers below market value shall not be applied by virtue of the Tax Avoidance Act. Swedish Orphan Biovitrum takes the view that the Tax Agency ought not to succeed in proving its case in relation to this new ground either. On 3 March 2011, the Administrative Court announced that they uphold the Tax Agency's request, explaining that Swedish Orphan Biovitrum under the tax law will be charged an amount of SEK 232.2 M as revenue in the 2005 tax year. The company has appealed.

As stated in the Annual Report 2010 the sellers of the pharmaceutical company Arexis, which was aquired in August 2005, have made a claim against Swedish Orphan Biovitrum in the amount of approx SEK 325 M. The sellers of Arexis claim that Swedish Orphan Biovitrum has not performed its obligations under the share purchase agreement entered into at the time of acquisition. Swedish Orphan Biovitrum have contested all claims presented by the sellers. The sellers have requested arbitration regarding parts of the above mentioned claim as well as, regarding the other parts, an expert determination provided for in the agreement.

Telephone conference

The interim report for the fourth quarter and full year 2011 will be presented by CEO Geoffrey McDonough and CFO Lars Sandström at a media and analyst telephone conference.

Time: Thursday, 23 February 2012 at 3 p.m. (CET)

To participate in the telephone conference, please call: SE: +46 (0)8 505 598 09 UK: +44 (0)207 750 9950 US: +1 866 676 58 69

The presentation can be followed live or afterwards at www.sobi.com

For more information, please contact: Lars Sandström, CFO, Telephone: +46 8 697 26 33
Financial calendar 2012
Annual Report 2011 5 April 2012
Interim Report, January-March 26 April 2012
Annual General Meeting 26 April 2012
Interim Report, January-June 19 July 2012
Interim Report, January-September 30 October 2012

The above information has been made public in accordance with the Swedish Securities Market Act and/or the Financial Instruments Trading Act. The information was released for public distribution on 23 February 2012 at 8.30 CET.