Sol-Gel Technologies Ltd. — Director's Dealing 2025

Nov 17, 2025

SEC Form 3 — Initial Statement of Beneficial Ownership

Issuer: Sol-Gel Technologies Ltd. (SLGL)
CIK: 0001684693
Period of Report: 2025-11-13

Reporting Person: Opaleye Management Inc. (10% Owner)

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares, par value NIS 1.00 per share	357367	Indirect
Ordinary Shares, par value NIS 1.00 per share	10000	Indirect

Footnotes

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Represents securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 3 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.