Sol-Gel Technologies Ltd. — Director's Dealing 2025

Dec 31, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Sol-Gel Technologies Ltd. (SLGL)
CIK: 0001684693
Period of Report: 2025-12-29

Reporting Person: Opaleye Management Inc. (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-12-29	Ordinary Shares, par value NIS 1.00 per share.	P	8638	$41.8539	Acquired	386073	Indirect
2025-12-30	Ordinary Shares, par value NIS 1.00 per share.	P	35169	$41.9866	Acquired	421242	Indirect
2025-12-31	Ordinary Shares, par value NIS 1.00 per share.	P	22497	$41.9942	Acquired	443739	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares, par value NIS 1.00 per share.	10000	Indirect

Footnotes

F1: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

F2: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

F3: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $41.5391 to $41.99. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F4: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $41.8008 to $42.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F5: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $39.95 to $42.00. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F6: Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.