SmartKem, Inc. — Director's Dealing 2025

May 29, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: SmartKem, Inc. (SMTK)
CIK: 0001817760
Period of Report: 2025-05-28

Reporting Person: de Boer Klaas (Director)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-05-28	Stock Option (right to Buy)	$2.51	A	23915	Acquired	2035-04-15	Common Stock (23915)	Direct

Footnotes

F1: The stock option grant was approved by the Compensation Committee of SmartKem, Inc.'s (the "Company") board of directors on April 15, 2025, subject to stockholder approval of an Amendment to the SmartKem, Inc. 2021 Equity Incentive Plan (the "Amendment"). The Company's stockholders approved the Amendment on May 28, 2025.

F2: The option vests as follows: 25% on the date of grant with the remaining shares to vest in equal monthly installments over a period of 36 months commencing on May 15, 2025 and on the 15th date of each month thereafter.