Silence Therapeutics plc — Director's Dealing 2020

Oct 16, 2020

National Storage Mechanism | Additional information

RNS Number : 3723C

Silence Therapeutics PLC

16 October 2020

Director Dealing

16th October 2020

LONDON, Silence Therapeutics plc, AIM:SLN and Nasdaq: SLN ("Silence" or "the Company"), a leader in the discovery, development and delivery of novel short interfering ribonucleic acid (siRNA) therapeutics for the treatment of diseases with significant unmet medical need, today announces that, on the 14th October 2020, 1,258 Shares were purchased by Alistair Gray, Non-Executive Director of the Company, at £3.97 per share.

Following this purchase, Alistair Gray is interested in 9,903 ordinary shares (0.01%) of the issued share capital of the Company.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them

1.

Details of the person discharging managerial responsibilities (PDMR) / person closely associated

a)

Name

Alistair Gray

2.

Reason for the notification

a)

Position / status

Non-Executive Director

b)

Initial notification / Amendment

Initial notification

3.

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

Silence Therapeutics plc

b)

LEI

213800SSURRJBX85SQ91

4

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial instrument, type of instrument

Identification code

Ordinary Shares of 5 pence each in Silence Therapeutics plc

ISIN for Silence Therapeutics plc Ordinary Shares:

GB00B9GTXM62

b)

Nature of the transaction

Purchase of Ordinary Shares in Silence Therapeutics plc

c)

Prices(a) and volume(s)

Price	Volume
£3.9686	1,258

d)

Aggregated information

- Aggregated volume

- Price

NA - single trade

e)

Date of the transaction

14 October 2020

f)

Place of the transaction

London Stock Exchange, AIM

Enquiries:

Silence Therapeutics plc  Gem Hopkins, Head of IR & Corporate Communications	Tel:  +1 (646) 637-3208
Investec Bank plc (Nominated Adviser and Broker) Daniel Adams/Gary Clarence	Tel:  +44 (0) 20 7597 5970
European IR Consilium Strategic Communications Mary-Jane Elliott/Chris Welsh/Angela Gray [email protected]	Tel: +44 (0) 20 3709 5700
US IR Westwicke Partners Peter Vozzo [email protected]	Tel: +1 (443) 213-0505

About Silence Therapeutics plc

Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet medical need. Silence's proprietary technology can be used to engineer short interfering ribonucleic acids (siRNAs) that bind specifically to and silence, through the RNAi pathway, almost any gene in the human genome to which siRNA can be delivered. Silence's wholly owned product candidates include SLN360 designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high levels of Lipoprotein(a) and SLN124 to address beta-thalassemia and myelodysplastic syndrome. Silence is also developing a C3 targeting programme, SLN500, in partnership with Mallinckrodt Pharmaceuticals to reduce the expression of the C3 protein for the treatment of complement pathway-mediated diseases.  Silence maintains ongoing research and collaborations with AstraZeneca, Mallinckrodt Pharmaceuticals and Takeda. For more information, please visit: https://www.silence-therapeutics.com/

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