SCANCELL HOLDINGS PLC — Director's Dealing 2020

Apr 27, 2020

National Storage Mechanism | Additional information

RNS Number : 0261L

Scancell Holdings Plc

27 April 2020

27 April 2020

Scancell Holdings plc

("Scancell" or the "Company")

Director Dealing

Scancell (AIM: SCLP), the developer of novel immunotherapies for the treatment of cancer announces that Vulpes Life Science Fund, a person closely associated with Martin Diggle, Non- Executive Director, has sold 500,000 ordinary shares of 0.1p each ('Ordinary Shares') in the Company on 24 April 2020 at a price of 8p per share. Following the sale, Vulpes Life Science Fund holds 80,049,311 ordinary shares representing 17.2% of the company.

NOTIFICATION AND PUBLIC DISCLOSURE OF TRANSACTIONS BY PERSONS DISCHARGING

MANAGERIAL RESPONSIBILITIES AND PERSONS CLOSELY ASSOCIATED WITH THEM

1	Details of the person discharging managerial responsibilities/person closely associated
a)	Name	Vulpes Life Science Fund
2	Reason for the notification
a)	Position/status	Person closely associated with Martin Diggle, Non-Executive Director
b)	Initial notification/Amendment	Initial notification
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a)	Name	Scancell Holdings plc
b)	LEI	2138008RXEG856SNP666
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a)	Description of the financial instrument, type of instrument	Ordinary Shares of 0.1 pence each
b)	Identification Code	GB00B63D3314
c)	Nature of the transaction	Sale of Ordinary Shares
d)	Price(s) and volume(s)	500,000 Ordinary Shares 8 pence per Ordinary Share
e)	Aggregated information - Aggregated volume - Price	N/A (single transaction)
f)	Date of the transaction	24 April 2020
g)	Place of the transaction	London Stock Exchange, AIM

- ENDS -

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014 (MAR).

For more information, please contact:

Scancell Holdings plc	+44 (0)20 3727 1000
Dr John Chiplin, Chairman
Dr Cliff Holloway, CEO
Panmure Gordon (UK) Limited (Nominated Adviser and Joint Broker)	+44 (0) 20 7886 2500
Corporate Finance: Freddy Crossley, Emma Earl
Corporate Broking: James Stearns
FTI Consulting	+44 (0)20 3727 1000
Simon Conway
Natalie Garland-Collins

Notes for Editors

About Scancell

Scancell is developing novel immunotherapies for the treatment of cancer based on its ImmunoBody® and Moditope® technology platforms.

ImmunoBody® vaccines target dendritic cells and stimulate both parts of the cellular immune system. They have the potential to be used as monotherapy or in combination with checkpoint inhibitors and other agents. This platform has the potential to enhance tumour destruction, prevent disease recurrence and extend survival.

·      SCIB1, the lead programme, is being developed for the treatment of melanoma. A phase 1/2 clinical trial has so far successfully demonstrated survival data of more than five years.

·      SCIB2 is being developed for the treatment of non-small cell lung cancer and other solid tumours. Scancell has entered into a clinical development partnership with Cancer Research UK (CRUK) for SCIB2.

Moditope® represents a completely new class of potent and selective immunotherapy agents based on stress-induced post-translational modifications (siPTM). It stimulates the production of killer CD4 T cells which overcome the immune suppression induced by tumours, allowing activated T cells to seek out and kill tumour cells that would otherwise be hidden from the immune system. Moditope® alone, or in combination with other agents, has the potential to treat a wide variety of cancers.

·      Modi-1 is being developed for the treatment of solid tumours including triple negative breast cancer, ovarian cancer and head and neck cancer.

AvidiMab™ is a patent protected technology platform which increases the avidity of human antibodies by promoting non-covalent Fc-Fc interactions. This modification induces the direct tumour cell killing properties of Scancell's anti-glycan monoclonal antibodies (mAbs) but has broad potential to increase the avidity or potency of any therapeutic monoclonal antibody including those being developed for autoimmune diseases, as well as cancer.

In response to the COVID-19 pandemic, Scancell has turned its clinical expertise in cancer to produce a simple, safe, cost-effective and scalable vaccine to induce both durable T cell responses and virus neutralising antibodies against SARS-Cov-2, the virus that causes COVID-19. The Company believes this combined T cell and antibody approach should give more potent and long-lasting responses, ultimately leading to better protection.

For further details, please see our website:  www.scancell.co.uk 

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