RYVU Therapeutics S.A. — Director's Dealing 2023

Feb 3, 2023

Notification from a person discharging managerial responsibilities inthe Company - Article 19 of MAR

The Management Board of Ryvu Therapeutics S.A. (_quot;Company_quot;) herebyinforms that the Company received a notification prepared on the basisof Article 19(1) of the Market Abuse Regulation from Mr. PiotrRomanowski - Chairman of the Supervisory Board of the Company as aperson discharging managerial responsibilities in the Company, drawn upin relation to the sale of the Company's shares.

The notification is enclosed to this report.