RYVU Therapeutics S.A. — Director's Dealing 2023

May 25, 2023

Notification from person discharging managerial responsibilities in theCompany due to execution of the Stock Grant Program

The Management Board of Ryvu Therapeutics S.A. with its registeredoffice in Krakow, Poland (_quot;Company_quot;) hereby informs that the Companyreceived a notification prepared in accordance with Article 19.1 of MARfrom Mr. Hendrik Nogai - Member of the Management Board as from theperson discharging managerial responsibilities in the Company due to theimplementation of a non-diluting incentive program about which theCompany informed in the current reports No. 10/2021 of April 20th, 2021and No. 14/2021 of May 17th, 2021.The notification is attachedto this report.