RHYTHM PHARMACEUTICALS, INC. — Director's Dealing 2025

Dec 15, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: RHYTHM PHARMACEUTICALS, INC. (RYTM)
CIK: 0001649904
Period of Report: 2025-12-11

Reporting Person: Cramer Pamela J. (Chief Human Resources Officer)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-12-11	Common Stock	M	3350	$27.35	Acquired	24164	Direct
2025-12-11	Common Stock	S	3350	$111.0	Disposed	20814	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-12-11	Stock Options (Right to Buy)	$27.35	M	3350	Disposed	2033-01-31	Common Stock (3350)	Direct

Footnotes

F1: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025.

F2: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.