RHYTHM BIOSCIENCES LIMITED — Share Issue/Capital Change 2021

Jul 25, 2021

Announcement Summary

Entity name

RHYTHM BIOSCIENCES LIMITED

Date of this announcement

Monday July 26, 2021

The +securities the subject of this notification are:

+Other securities issued under an +employee incentive scheme that are not intended to be quoted on ASX

Total number of +securities to be issued/transferred

ASX +securitycode	Security description	Total number of+securities to beissued/transferred	Issue date
New class - codeto be confirmed	OPTION EXPIRING 31-JUL-2024 EX 180C	1,895,000	26/07/2021

Refer to next page for full details of the announcement

Part 1 - Entity and announcement details

1.1 Name of entity

RHYTHM BIOSCIENCES LIMITED

We (the entity named above) give notice of the issue, conversion or payment up of the following unquoted +securities.

1.2 Registered number type ABN

Registration number 59619459335

1.3 ASX issuer code RHY

1.4 The announcement is New announcement

1.5 Date of this announcement

26/7/2021

Part 2 - Issue details

2.1 The +securities the subject of this notification are:

+Other securities issued under an +employee incentive scheme that are not intended to be quoted on ASX

2.2a This notification is given in relation to an issue of +securities in a class which is not quoted on ASX and which:

does not have an existing ASX security code ("new class")

Equity Securities

Part 3C - number and type of +securities the subject of this notification (new class) where issue has not previously been notified to ASX

in an Appendix 3B

ASX +security code	+Security description
New class - code to be confirmed	OPTION EXPIRING 31-JUL-2024 EX 180C
+Security type	ISIN code
Options
Date the +securities the subject of this notification were issued
26/7/2021
	Will all the +securities issued in this class rank equally in all respects from their issue date?
Yes
No	Were any of the +securities issued to +key management personnel (KMP) or an +associate?
listing rule 6.1?No	Have you received confirmation from ASX that the terms of the +securities are appropriate and equitable under

Options Details

+Security currency AUD - Australian Dollar Exercise price AUD 1.80000000 Expiry date 31/7/2024

Details of the existing class of +security that will be issued upon exercise or conversion of this new class of company option

Other

Equity Securities

Description

Fully paid ordinary shares

Please provide a URL link for a document lodged with ASX detailing the terms of the +employee incentive scheme or a summary of the terms

https://cdn-api.markitdigital.com/apiman-gateway/ASX/asx-research/1.0/file/2924-02290235-3A551918?access\_token=83 ff96335c2d45a094df02a206a39ff4

Any other information the entity wishes to provide about the +securities the subject of this notification

Issue details

Number of +securities

1,895,000

Equity Securities

Part 4 - +Securities on issue

Following the issue, conversion or payment up of the +securities the subject of this application, the +securities ofthe entity will comprise:(A discrepancy in these figures compared to your own may be due to a matter of timing if there is more than oneapplication for quotation/issuance currently with ASX for processing.)
4.1 Quoted +Securities (Total number of each +class of +securities quoted)
ASX +security code and description	Total number of+securities on issue
RHY : ORDINARY FULLY PAID	202,170,811
4.2 Unquoted +Securities (Total number of each +class of +securities issued but not quoted on ASX)
ASX +security code and description	Total number of+securities on issue
RHYAH : OPTION EXPIRING 14-SEP-2023 EX 20C	7,475,000

New class - code to be confirmed : OPTION EXPIRING 31-JUL-2024 EX 180C 1,895,000

Equity Securities

Part 5 - Other Listing Rule requirements

5.1 Were the +securities issued under an exception in Listing Rule 7.2 and therefore the issue did not need any security holder approval under Listing Rule 7.1? Yes

5.1a Select the number of the applicable exception in Listing Rule 7.2

13