RHYTHM BIOSCIENCES LIMITED — Share Issue/Capital Change 2021

Aug 3, 2021

ASX Announcement

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ASX code: RHY ACN: 619 459 335

4 August 2021

NOTICE UNDER SECTION 708A(5)(e) OF THE CORPORATIONS ACT 2001

• (a) The Company has issued 75,000 fully paid ordinary shares in the Company via the conversion of unlisted ESOP options.

• (b) The shares were issued without disclosure to investors under Part 6D.2 of the Corporations Act.

• (c) As at the date of this notice, the Company has complied with:

  • the provisions of Chapter 2M of the Corporations Act, as they apply to the Company; and

  • section 674 of the Corporation Act.

• (d) As at the date of this notice, there is no 'excluded information' (within the meaning of sections 708A(7) and 708A(8) of the Corporations Act) required to be disclosed under section 708A(6)(e) of the Corporations Act.

Released with the authority of the Board.

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Adrien Wing Company Secretary

Australian Registered Office Level 2, 480 Collins Street Melbourne VIC 3000 www.rhythmbio.com

Rhythm Biosciences Issued Capital ACN: 619 459 335 202,170,811 Shares ASX: RHY 10,295,000 Options

Directors Otto Buttula – Chairman of the Board Trevor John Lockett – Executive Director Louis James Panaccio – Non-Executive Director Eduardo Vom – Non-Executive Director