RHYTHM BIOSCIENCES LIMITED — Share Issue/Capital Change 2021

Nov 24, 2021

Announcement Summary

Entity name

RHYTHM BIOSCIENCES LIMITED

Date of this announcement

Thursday November 25, 2021

The +securities the subject of this notification are:

+Securities issued as part of a transaction or transactions previously announced to the market in an Appendix 3B that are not quoted, and are not intended to be quoted, on ASX

Total number of +securities to be issued/transferred

ASX +securitycode	Security description	Total number of+securities to beissued/transferred	Issue date
RHYAI	OPTION EXPIRING 31-JUL-2024 EX $1.80	5,300,000	24/11/2021

Refer to next page for full details of the announcement

Part 1 - Entity and announcement details

1.1 Name of entity

RHYTHM BIOSCIENCES LIMITED

We (the entity named above) give notice of the issue, conversion or payment up of the following unquoted +securities.

1.2 Registered number type ABN

Registration number

59619459335

1.3 ASX issuer code RHY

1.4 The announcement is New announcement

1.5 Date of this announcement

25/11/2021

Part 2 - Issue details

2.1 The +securities the subject of this notification are:

+Securities issued as part of a transaction or transactions previously announced to the market in an Appendix 3B that are not quoted, and are not intended to be quoted, on ASX

Previous Appendix 3B details:

Announcement Date andTime	Announcement Title	Selected Appendix 3B to submit quotationrequest
27-Jul-2021 09:20	New - Proposed issue of securities -RHY	A placement or other type of issue

2.3a.2 Are there any further issues of +securities yet to take place to complete the transaction(s) referred to in the Appendix 3B? No

Equity Securities

Part 3A - number and type of +securities the subject of this notification (existing class or new class) where issue has previously been

notified to ASX in an Appendix 3B

Placement Details

ASX +security code and description RHYAI : OPTION EXPIRING 31-JUL-2024 EX $1.80

Date the +securities the subject of this notification were issued

24/11/2021

Any other information the entity wishes to provide about the +securities the subject of this notification

Issue details

Number of +securities 5,300,000

Were the +securities issued for a cash consideration? No

Please describe the consideration being provided for the +securities

Refer to the Notice of Meeting lodged with ASX on 20 October 2021 for further information.

Part 4 - +Securities on issue

Following the issue, conversion or payment up of the +securities the subject of this application, the +securities of the entity will comprise: (A discrepancy in these figures compared to your own may be due to a matter of timing if there is more than one application for quotation/issuance currently with ASX for processing.) 4.1 Quoted +Securities (Total number of each +class of +securities quoted) ASX +security code and description Total number of +securities on issue RHY : ORDINARY FULLY PAID 208,875,513

4.2 Unquoted +Securities (Total number of each +class of +securities issued but not quoted on ASX)

ASX +security code and description	Total number of+securities on issue
RHYAK : OPTION EXPIRING 31-AUG-2022 EX $1.20	3,276,484
RHYAL : OPTION EXPIRING 31-JUL-2024 $1.80	3,276,700
RHYAH : OPTION EXPIRING 14-SEP-2023 EX 20C	7,325,000
RHYAI : OPTION EXPIRING 31-JUL-2024 EX $1.80	8,195,000

Equity Securities