RHYTHM BIOSCIENCES LIMITED — Director's Dealing 2021

Sep 8, 2021

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Rhythm Biosciences Limited
ABN	59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Otto Buttula
Date of last notice	3 September 2020

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Direct or indirect interest	Indirect
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	1)NewfoundInvestmentsPtyLtd2)Webinvest Pty Ltd
Date of change	9 September 2021
No. of securities held prior to change	1)Newfound Investments Pty Ltd10,733,333 fully paid ordinary shares2)Webinvest Pty Ltd16,666,667 fully ordinary paid shares
Class	a) Fully paid ordinary shares (ASX: RHY)b) Unlisted options (ASX: RHYAK)expiring 31 August 2022c) Unlisted options (ASX: RHYAL)expiring 31 July 2024

+ See chapter 19 for defined terms.

Number acquiredNumber disposed	a) 685,001b) 342,501c) 342,501Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$582,251
No. of securities held after change	1)Newfound Investments Pty Ltd11,001,667 fully paid ordinary shares(ASX:RHY)134,167 Unlisted options(ASX:RHYAK) expiring 31 August 2022134,167 Unlisted options(ASX: RHYAL) expiring 31 July 20242)Webinvest Pty Ltd17,083,334 fully ordinary paid shares(ASX:RHY)208,334 Unlisted options(ASX:RHYAK) expiring 31 August 2022208,334 Unlisted options(ASX: RHYAL) expiring 31 July 2024
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	Acceptance of offer pursuant to nonrenounceable rights issue lodged withASX on 30 July 2021.

Detail of contract	n/a
Nature of interest
Name of registered holder(if issued securities)
Date of change

+ See chapter 19 for defined terms.

No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed
Interest acquired
Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuation
Interest after change

Were the interests in the securities or contracts detailed	n/a
above traded during a +closed periodwhere prior written
clearance was required?
If so, was prior written clearance provided to allow the
trade to proceed during this period?
If prior written clearance was provided, on what date was
this provided?

+ See chapter 19 for defined terms.

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Rhythm Biosciences Limited
ABN	59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Lou Panaccio
Date of last notice	3 September 2020

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Direct or indirect interest	Indirect
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	Tercus Pty Ltd
Date of change	9 September 2021
No. of securities held prior to change	Held by Beneficial interest held throughTercus Pty Ltd800,000 fully paid ordinary shares
Class	1)Fully paid ordinary shares (ASX: RHY)2)Unlistedoptions(ASX:RHYAK)expiring 31 August 20223)Unlistedoptions(ASX:RHYAL)expiring 31 July 2024
Number acquired	1)20,0002)10,0003)10,000
Number disposed	Nil

+ See chapter 19 for defined terms.

Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$17,000
No. of securities held after change	Held by Beneficial interest held throughTercus Pty Ltd820,000fullypaidordinaryshares(ASX:RHY)10,000Unlistedoptions(ASX:RHYAK)expiring 31 August 202210,000 Unlisted options (ASX: RHYAL)
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	expiring 31 July 2024Acceptance of offer pursuant to nonrenounceable rights issue lodged withASX on 30 July 2021.

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

Detail of contract
Nature of interest
Name of registered holder
(if issued securities)
Date of change
No. and class of securities to which
interest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed
Interest acquired
Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide details
and an estimated valuation
Interest after change

+ See chapter 19 for defined terms.

Were the interests in the securities or contracts detailedabove traded during a +closed periodwhere prior writtenclearance was required?
If so, was prior written clearance provided to allow thetrade to proceed during this period?
If prior written clearance was provided, on what date wasthis provided?

+ See chapter 19 for defined terms.

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Rhythm Biosciences Limited
ABN	59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Eduardo Vom
Date of last notice	3 September 2020

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Direct or indirect interest	Direct
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.
Date of change	9 September 2021
No. of securities held prior to change	1)Eduardo Vom –1,136,000 fully paidordinary shares2)Natalie Patterson (spouse) - 2,416,667fully paid ordinary shares
Class	a)Fully ordinary paid shares (ASX: RHY)b)Unlistedoptions(ASX:RHYAK)expiring 31 August 2022c)Unlistedoptions(ASX:RHYAL)expiring 31 July 2024
Number acquired	a)88,817b)44,409c)44,409

+ See chapter 19 for defined terms.

Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$75,494
No. of securities held after change	1)Eduardo Vom1,164,400fullypaidordinaryshares(ASX:RHY)14,200Unlistedoptions(ASX:RHYAK)expiring 31 August 202214,200Unlisted options (ASX: RHYAL)expiring 31 July 20242)Natalie Patterson (spouse) -2,477,084fully paid ordinary shares(ASX:RHY)30,209Unlisted options (ASX:RHYAK)expiring 31 August 202230,209Unlisted options (ASX: RHYAL)expiring 31 July 2024
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	Acceptance of offer pursuant to nonrenounceable rights issue lodged withASX on 30 July 2021.

Detail of contract
Nature of interest
Name of registered holder
(if issued securities)
Date of change
No. and class of securities to which
interest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed
Interest acquired
Interest disposed

+ See chapter 19 for defined terms.

Value/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuation
Interest after change

Were the interests in the securities or contracts detailed
above traded during a +closed periodwhere prior written
clearance was required?
If so, was prior written clearance provided to allow the
trade to proceed during this period?
If prior written clearance was provided, on what date was
this provided?

+ See chapter 19 for defined terms.

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Rhythm Biosciences Limited
ABN	59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Trevor Lockett
Date of last notice	20 November 2020

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Direct or indirect interest	Direct
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.
Date of change	9 September 2021
No. of securities held prior to change	160,000 fully paid ordinary shares held byMrs Linda Jane Lockett & Dr Trevor JohnLockett1,500,000 unlisted options held by MrsLinda Jane Lockett & Dr Trevor JohnLockett to acquire fully paid ordinaryshares having an exercise price of $0.20and expiring 14 September 2023.
Class	1)Fully paid ordinary shares (ASX: RHY)2)Unlistedoptions(ASX:RHYAK)expiring 31 August 20223)Unlistedoptions(ASX:RHYAL)expiring 31 July 2024

+ See chapter 19 for defined terms.

Number acquired
	1)4,000
	2)2,000
	3)2,000
Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$3,400
No. of securities held after change	164,000 fully paid ordinary shares held byMrs Linda Jane Lockett & Dr Trevor JohnLockett (ASX:RHY)
	1,500,000unlisted options held by MrsLinda Jane Lockett & Dr Trevor JohnLockett to acquire fully paid ordinaryshares having an exercise price of $0.20and expiring 14 September 2023.
	2,000Unlistedoptions(ASX:RHYAK)expiring 31 August 20222,000 Unlisted options (ASX: RHYAL)expiring 31 July 2024
Nature of changeExample: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	Acceptance of offer pursuant to nonrenounceable rights issue lodged withASX on 30 July 2021.

Detail of contract	n/a
Nature of interest
Name of registered holder
(if issued securities)
Date of change
No. and class of securities to which
interest related prior to change
Note: Details are only required for a contract inrelation to which the interest has changed
Interest acquired

+ See chapter 19 for defined terms.

Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide detailsand an estimated valuation
Interest after change

Were the interests in the securities or contracts detailed	n/a
above traded during a +closed periodwhere prior written
clearance was required?
If so, was prior written clearance provided to allow thetrade to proceed during this period?
If prior written clearance was provided, on what date wasthis provided?

+ See chapter 19 for defined terms.