RHYTHM BIOSCIENCES LIMITED — Director's Dealing 2021

Nov 30, 2021

Appendix 3X Initial Director’s Interest Notice

Rule 3.19A.1

Appendix 3X

Initial Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/9/2001.

Name of entity Rhythm Biosciences Limited ABN 59 619 459 335

We (the entity) give ASX the following information under listing rule 3.19A.1 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Glenn Gilbert
Date of appointment	1 December 2021

Part 1 - Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

Glenn Gilbert:

1,183,341 fully paid ordinary shares (ASX: RHY)

1,750,000 unlisted options exercisable at $0.20 on or before 14 September 2023 (ASX: RHYAH)

Lege Investments Pty Ltd :

29,792 unlisted options exercisable at $1.20 on or before 31 August 2022 (ASX: RHYAK) 29,792 unlisted option exercisable at $1.80 on or before 31 July 20214 (ASX: RHYAL) 1,750,000 unlisted options exercisable at $0.20 on before 14 September 2023 (ASX: RHYAH) 2,000,000 unlisted options exercisable at $1.80 on or before 31 July 2024 (ASX: RHYAI)

• See chapter 19 for defined terms.

11/3/2002

Appendix 3X Page 1

Appendix 3X Initial Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interest Number & class of Securities Note: Provide details of the circumstances giving rise to the relevant interest. Nil

Part 3 – Director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Not applicable
Nature of interest
Name of registered holder(if issued securities)
No. and class of securities to whichinterest relates

• See chapter 19 for defined terms.

Appendix 3X Page 2

11/3/2002