RHYTHM BIOSCIENCES LIMITED — Capital/Financing Update 2021

Dec 1, 2021

Announcement Summary

Entity name

RHYTHM BIOSCIENCES LIMITED

Announcement Type

New announcement

Date of this announcement

Thursday December 02, 2021

The +securities to be quoted are:

+Securities issued, transferred or re-classified as a result of options being exercised or other +convertible securities being converted

Total number of +securities to be quoted

ASX +securitycode	Security description	Number of +securities tobe quoted	Issue date
RHY	ORDINARY FULLY PAID	1,768	02/12/2021

Refer to next page for full details of the announcement

Part 1 - Entity and announcement details

1.1 Name of entity

RHYTHM BIOSCIENCES LIMITED

We (the entity named above) apply for +quotation of the following +securities and agree to the matters set out in Appendix 2A of the ASX Listing Rules.

1.2 Registered number type ABN

Registration number 59619459335

1.3 ASX issuer code RHY

1.4 The announcement is

New announcement

1.5 Date of this announcement

2/12/2021

Part 2 - Type of Issue

2.1 The +securities to be quoted are:

+Securities issued, transferred or re-classified as a result of options being exercised or other +convertible securities being converted

2.2 The +securities to be quoted are:

Additional +securities in a class that is already quoted on ASX ("existing class")

Part 3B - number and type of +securities to be quoted (existing class) where issue has not previously been notified to ASX in an

Appendix 3B

	Existing +securities converting into additional +securities in an existing class
FROM (Existing Class)ASX +security code and description
RHYAK : OPTION EXPIRING 31-AUG-2022 EX $1.20
TO (Existing Class)
ASX +security code and description
RHY : ORDINARY FULLY PAID
Please state the number of optionsthat were exercised or other+convertible securities that were	The first date the options wereexercised or other +convertiblesecurities were converted	The last date the options wereexercised or other +convertiblesecurities were converted
converted	2/12/2021	2/12/2021

1,028

Is this all of the options or other +convertible securities on issue of that type (ie have all of those options now been exercised or have all of those convertible securities now been converted)? No

The right of the holder of the options or other +convertible securities to receive the +underlying securities is being satisfied by:

An issue of new +securities

The underlying securities being received by the holder are: Intended to be, but are not yet, quoted by ASX

Were the options being exercised or other +convertible securities being converted issued under an +employee incentive scheme? No

Issue date

2/12/2021

Will the +securities to be quoted rank equally in all respects from their issue date with the existing issued +securities in that class? Yes

Issue details

Number of +securities to be quoted1,028
Are the +securities being issued for a cash consideration?Yes
In what currency is the cash consideration being paid?	What is the issue price per +security?
AUD - Australian Dollar	AUD 1.20000000
Any other information the entity wishes to provide about the +securities to be quoted

Existing +securities converting into additional +securities in an existing class

FROM (Existing Class) ASX +security code and description RHYAL : OPTION EXPIRING 31-JUL-2024 $1.80

TO (Existing Class) ASX +security code and description

RHY : ORDINARY FULLY PAID

Please state the number of optionsthat were exercised or other+convertible securities that were	The first date the options wereexercised or other +convertiblesecurities were converted
converted	2/12/2021	2/12/2021
740

The last date the options were exercised or other +convertible securities were converted

Is this all of the options or other +convertible securities on issue of that type (ie have all of those options now been exercised or have all of those convertible securities now been converted)? No

The right of the holder of the options or other +convertible securities to receive the +underlying securities is being satisfied by:

An issue of new +securities

The underlying securities being received by the holder are: Intended to be, but are not yet, quoted by ASX

Were the options being exercised or other +convertible securities being converted issued under an +employee incentive scheme? No

Issue date

2/12/2021

Will the +securities to be quoted rank equally in all respects from their issue date with the existing issued +securities in that class? Yes

Issue details

Number of +securities to be quoted740
Are the +securities being issued for a cash consideration?Yes
In what currency is the cash consideration being paid?	What is the issue price per +security?
AUD - Australian Dollar	AUD 1.80000000
Any other information the entity wishes to provide about the +securities to be quoted

Part 4 - Issued capital following quotation

Following the quotation of the +securities the subject of this application, the issued capital of the entity will

comprise:

(A discrepancy in these figures compared to your own may be due to a matter of timing if there is more than one application for quotation/issuance currently with ASX for processing.)

4.1 Quoted +securities (total number of each +class of +securities quoted on ASX following the +quotation of the +securities subject of this application)

ASX +security code and description	Total number of+securities on issue
RHY : ORDINARY FULLY PAID	208,877,281

4.2 Unquoted +securities (total number of each +class of +securities issued but not quoted on ASX)

ASX +security code and description	Total number of+securities on issue
RHYAK : OPTION EXPIRING 31-AUG-2022 EX $1.20	3,275,456
RHYAL : OPTION EXPIRING 31-JUL-2024 $1.80	3,275,960
RHYAH : OPTION EXPIRING 14-SEP-2023 EX 20C	7,325,000
RHYAI : OPTION EXPIRING 31-JUL-2024 EX $1.80	8,195,000