Revolution Medicines, Inc. — Director's Dealing 2021

Feb 27, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Revolution Medicines, Inc. (RVMD)
CIK: 0001628171
Period of Report: 2021-02-24

Reporting Person: Third Rock Ventures III, L.P. (10% Owner)
Reporting Person: Third Rock Ventures GP III, L.P. (10% Owner)
Reporting Person: TRV GP III, LLC (10% Owner)
Reporting Person: STARR KEVIN P (10% Owner)
Reporting Person: TEPPER ROBERT I (10% Owner)
Reporting Person: LEVIN MARK J (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-02-24	Common Stock	J	1500000	—	Disposed	5524031	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1909317	Indirect
Common Stock	0	Indirect
Common Stock	116334	Indirect
Common Stock	12925	Indirect
Common Stock	129256	Indirect
Common Stock	129258	Indirect

Footnotes

F1: On February 24, 2021, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration, 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F2: These shares are directly held by TRV III. The general partner of TRV III is TRV GP III. The general partner of TRV GP III is TRV GP III, LLC ("TRV GP III LLC"). The individual managers of TRV GP III LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP III, TRV GP III LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares

F3: These shares are directly held by Third Rock Ventures II, L.P. ("TRV II"). The general partner of TRV II is Third Rock Ventures GP II, L.P. ("TRV GP II"). The general partner of TRV GP II is TRV GP II, LLC ("TRV GP II LLC"). The individual managers of TRV GP II LLC are Levin, Starr and Tepper. Each of TRV GP II, TRV GP II LLC, Levin, Starr and Tepper disclaims beneficial ownership of these shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares.

F4: Third Rock Ventures IV, L.P. ("TRV IV") directly holds 1,419,900 shares of Common Stock of the Issuer. The general partner of TRV IV is Third Rock Ventures GP IV, L.P. ("TRV GP IV"). The general partner of TRV GP IV is TRV GP IV, LLC ("TRV GP IV LLC"). Each of the reporting persons and TRV GP IV and TRV GP IV LLC disclaims beneficial ownership of

F5: The shares are directly held by Levin. Includes Shares received in the distributions described in footnote (1) above.

F6: The shares are directly held by Levin Family 2014 Irrevocable Trust. Includes Shares received in the distributions described in footnote (1) above.

F7: The shares are directly held by Starr. Includes Shares received in the distributions described in footnote (1) above.

F8: The shares are directly held by Tepper. Includes Shares received in the distributions described in footnote (1) above.