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REPLIGEN CORP Director's Dealing 2007

Dec 19, 2007

30826_dirs_2007-12-19_369f5680-eb20-4b7b-b12a-f9fc7061f432.zip

Director's Dealing

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SEC Form 4/A — Form 4/A

Issuer: REPLIGEN CORP (RGEN)
CIK: 0000730272
Period of Report: 2007-12-13

Reporting Person: RUSCHE JAMES R (Senior Vice President)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2007-12-13 Common Stock S 900 $6.17 Disposed 114974 Direct
2007-12-13 c S 2357 $6.15 Disposed 112617 Direct
2007-12-13 Common Stock S 12443 $6.14 Disposed 100174 Direct
2007-12-13 Common Stock S 2200 $6.13 Disposed 97974 Direct
2007-12-13 Common Stock S 2100 $6.12 Disposed 95874 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2007-12-13 Common Stock $1.41 M 30000 Acquired 2008-04-29 Common stock (30000) Direct

Footnotes

F1: 7,500 shares exercisable at 4/29/1999, 4/29/2000, 4/29/2001 and 4/29/2002.

F2: Incorrectly reported zero in Part I, Block 5 as the Amount of Securities Beneficially Owned Following Reported Transaction.

F3: Incorrectly reported zero in Part I, Block 5 as the Amount of Securities Beneficially Owned Following Reported Transaction.

F4: Incorrectly reported zero in Part I, Block 5 as the Amount of Securities Beneficially Owned Following Reported Transaction.

F5: Incorrectly reported zero in Part I, Block 5 as the Amount of Securities Beneficially Owned Following Reported Transaction.

F6: Incorrectly left Part II blank. This section should have reflected exercise of 30,000 shares at $1.41 on 12/13/2007.

F7: 7,500 shares exercisable at 4/29/1999, 4/29/2000, 4/29/2001 and 4/29/2002.