PYC THERAPEUTICS LIMITED — Director's Dealing 2025

Dec 22, 2025

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	PYC Therapeutics Limited
ABN	48 098 391 961

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Peter Coleman
Date of last notice	18 November 2025

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest
(including registered holder)
Note: Provide details of the circumstances giving rise to the relevant
interest.
Date of change	23/12 2025
No. of securities held prior to change	Nil
Class	Unlisted Options with an exercise price of
	$1.80 each expiring19 November 2028
Number acquired	2,000,000
Number disposed	-
Value/Consideration	Issued as part of remuneration.
Note: If consideration is non-cash, provide details and estimated
valuation
No. of securities held after change	2,000,000 options with an exercise price of
	$1.80 each expiring 19 November 2028

• See chapter 19 for defined terms.

01/01/2011

Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

Nature of change Issued pursuant to Letter of Appointment. Example: on-market trade, off-market trade, exercise of options, Refer ASX release dated 13 November 2025 issue of securities under dividend reinvestment plan, participation in buy-back

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil
Nature of interest	-
Name of registered holder(if issued securities)	-
Date of change	-
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract inrelation to which the interest has changed	-
Interest acquired	-
Interest disposed	-
Value/ConsiderationNote: If consideration is non-cash, provide details andan estimated valuation	-
Interest after change	-

Part 3 –[+] Closed period

art 3 –+Closed period
Were the interests in the securities or contracts detailedabove traded during a+closed period where prior writtenclearance was required?	No
If so, was prior written clearance provided to allow thetrade to proceed during this period?	n/a
If prior written clearance was provided, on what date wasthis provided?	n/a

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011