PYC THERAPEUTICS LIMITED — Director's Dealing 2017

Oct 25, 2017

Appendix 3X and 3Z

PERTH, Australia, 26th October 2017: Phylogica Limited (ASX:PYC) (Phylogica or the Company), submits the following Appendices in relation to the appointment of Mr Sahm Nasseri and the retirement of Mr Rick Kendall as announced to ASX on Monday 23 October 2017;

Appendix 3X – Initial Directors Interest Notice – Mr Sahm Nasseri Appendix 3Z – Final Directors Interest Notice – Mr Rick Kendall

Yours faithfully

Kevin Hart

Company Secretary

ENDS

For further information, please contact:

INVESTORS MEDIA Stephanie Unwin CEO stephanieu@phylogica.com 0411 132 287

Ben Walsh WE Buchan bwalsh@buchanwe.com.au 0411 520 012

About Phylogica

Phylogica Limited (ASX: PYC) is a biotech company focused on commercialising its intracellular drug delivery platform and panning its Phylomer libraries to identify drug cargoes for development against a wide range of disease targets. Phylogica controls access to the world's most structurally diverse source of peptides called Phylomers, which have the ability to act as effective drug delivery agents and drug cargoes, penetrating cell walls to reach previously 'undruggable' targets across a range of disease types. Phylogica's platform of proprietary cell penetration peptides is showing promise in delivering a diverse range of drug cargoes into cells, and the company's lead asset program has identified a phylomer which can inhibit Myc, a protein responsible for the regulation of cancer cell growth. The company has had collaborations with several pharmaceutical companies including Roche, Medimmune, Pfizer, Janssen and is currently working with Genentech.

Tel: +61 8 9384 3284 | Fax: +61 8 9284 3801 www.phylogica.com Phylogica Ltd ABN 48 098 391 961

24.Rule 3.19A.1

Appendix 3X

Initial Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

	Name of entity PHYLOGICA LIMITED
ACN	098 391 961

We Phylogica Limited give ASX the following information under listing rule 3.19A.1 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	SAHM NASSERI
Date of Appointment	23October 2017

Part 1 - Director's relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Number & class of securities

NIL

+ See chapter 19 for defined terms.

Part 2 – Director's relevant interests in securities of which the director is not the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Nameofholder&natureofinterest	Number & class of Securities
Note: Provide details of the circumstances givingrise to the relevant interest.	NIL

Part 3 – Director's interests in contracts

Detail of contract	NIL
Nature of interest
Name of registered holder
(if issued securities)
No. and class of securities to which
interest relates

+ See chapter 19 for defined terms.

Rule 3.19A.3

Appendix 3Z

Final Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

	Name of entity	PHYLOGICA LIMITED
ACN	098 391 961

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	RICK KENDALL
Date of last notice	18 April 2017
Date that director ceased to be director	23 October 2017

Part 1 – Director's relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Number & class of securities

Nil

+ See chapter 19 for defined terms.

Part 2 – Director's relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interestNote: Provide details of the circumstances giving rise tothe relevant interest	Number & class of securities
Nil

Part 3 – Director's interests in contracts

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder	N/A
(if issued securities)
No. and class of securities to which	N/A
interest relates

+ See chapter 19 for defined terms.