PUMA BIOTECHNOLOGY, INC. — Director's Dealing 2016

May 27, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: PUMA BIOTECHNOLOGY, INC. (PBYI)
CIK: 0001401667
Period of Report: 2016-05-25

Reporting Person: EYLER CHARLES R (SEE REMARKS)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-05-25	Stock Option (Right to Buy)	$35.61	A	30000	Acquired	2026-05-24	Common Stock (30000)	Direct

Footnotes

F1: The vesting commencement date ("Vesting Commencement Date") of the option is May 25, 2016. The option vests (i) with respect to one-third (1/3) of the shares underlying the option on the first anniversary of the Vesting Commencement Date and (ii) with respect to 1/36th of the shares underlying the option, on each monthly anniversary of the Vesting Commencement Date thereafter, subject to Reporting Person's continued services with the Issuer.