PUMA BIOTECHNOLOGY, INC. — Director's Dealing 2012

Jan 31, 2012

SEC Form 3 — Initial Statement of Beneficial Ownership

Issuer: PUMA BIOTECHNOLOGY, INC. (NONE)
CIK: 0001401667
Period of Report: 2012-01-31

Reporting Person: Adage Capital Partners, L.P. (10% Owner)
Reporting Person: Adage Capital Advisors, L.L.C. (10% Owner)
Reporting Person: Gross Phillip (10% Owner)
Reporting Person: Atchinson Robert (10% Owner)
Reporting Person: ADAGE CAPITAL PARTNERS GP LLC (The Reporting Persons are no l)

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock, $0.0001 par value per share	3200000	Indirect

Footnotes

F1: The Shares of Common Stock to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of ACP. ACPGP, ACA, Robert Atchinson and Phillip Gross disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.