PUMA BIOTECHNOLOGY, INC. — Director's Dealing 2012

May 3, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: PUMA BIOTECHNOLOGY, INC. (PBYI)
CIK: 0001401667
Period of Report: 2012-05-01

Reporting Person: ADAGE CAPITAL PARTNERS GP LLC (10% Owner)
Reporting Person: Adage Capital Partners, L.P. (10% Owner)
Reporting Person: Adage Capital Advisors, L.L.C. (10% Owner)
Reporting Person: Atchinson Robert (10% Owner)
Reporting Person: Gross Phillip (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-01	Common Stock, par value $0.0001 per share ("Common Stock")	P	5000	$13.25	Acquired	3627195	Indirect
2012-05-03	Common Stock	P	8500	$13.25	Acquired	3635695	Indirect

Footnotes

F1: Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"), and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. ACPGP, ACA, Robert Atchinson and Phillip Gross disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.