PROTHENA CORP PUBLIC LTD CO — Director's Dealing 2016

May 25, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Prothena Corp plc (PRTA)
CIK: 0001559053
Period of Report: 2016-05-23

Reporting Person: Selkoe Dennis J. (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-05-23	Ordinary Shares, par value $0.01 per share	M	180	$16.42	Acquired	3025	Direct
2016-05-23	Ordinary Shares, par value $0.01 per share	S	180	$45.00	Disposed	2845	Direct
2016-05-24	Ordinary Shares, par value $0.01 per share	M	4820	$16.42	Acquired	7665	Direct
2016-05-24	Ordinary Shares, par value $0.01 per share	S	4820	$45.00	Disposed	2845	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-05-23	Stock Option (right to buy)	$16.42	M	180	Disposed	2023-07-21	Ordinary Shares (180)	Direct
2016-05-24	Stock Option (right to buy)	$16.42	M	4820	Disposed	2023-07-21	Ordinary Shares (4820)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares, par value $0.01 per share	1363	Indirect

Footnotes

F1: The sale reported on this Form 4 was effected pursuant to a Rule 10b5 1 trading plan adopted by the Reporting Person.