COMPANY PRESENTATION October 2017

Forward looking Statement

This presentation contains express or implied forward-looking statements within the Private Securities Litigation Reform Act of 1995 and other U.S. Federal securities laws. For example, we are using forward-looking statements when we discuss the expected timing of obtaining regulatory approval for our various patient trials and clinical data readout, proposed trials that may occur in the future, the timing and implementation of our collaborations with various partners and the execution of definitive agreements relating to such collaborations and the potential benefits and impact our products could have on improving patient health care. These forward-looking statements and their implications are based on the current expectations of our management only, and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: changes in technology and market requirements; we may encounter delays or obstacles in launching and/or successfully completing our clinical trials; our products may not be approved by regulatory agencies, our technology may not be validated as we progress further and our methods may not be accepted by the scientific community; we may be unable to retain or attract key employees whose knowledge is essential to the development of our products; unforeseen scientific difficulties may develop with our process; our products may wind up being more expensive than we anticipate; results in the laboratory may not translate to equally good results in real clinical settings; results of preclinical studies may not correlate with the results of human clinical trials; our patents may not be sufficient; our products may harm recipients; changes in legislation; inability to timely develop and introduce new technologies, products and applications; loss of market share and pressure on pricing resulting from competition, which could cause our actual results or performance to differ materially from those contemplated in such forward-looking statements. Except as otherwise required by law, we undertake no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. For a more detailed description of the risks and uncertainties affecting us, reference is made to our reports filed from time to time with the Securities and Exchange Commission

CORPORATE OVERVIEW

Cell therapy company using off the shelf placentaderived cell products
Entering late-stage trials in 3 indications
Multifactorial therapy releasing a range of therapeutic proteins in response to signals from patient's body
First in class 3D cell culturing technology allowing for efficient, controlled production of different cell productsin commercial quantities

FINANCIAL GLANCE

Pluristem Therapeutics Inc.	NASDAQ: PSTI TASE: PSTI
Stock Price (As of 10/27/2017)	\$1.97
Market Capitalization	~\$192 million
Cash and Marketable Securities (As of 6/30/2017)	\$26.7 million
Debt	\$0
Employees	180
Intellectual Property Ownership	115+ granted ~100 pending

The PLX Platform Technology

Best In Class GMP Facility

3D Manufacturing, In-house Cell Production Potential capability to manufacture up to 150,000 doses annually

* Chemistry, Manufacturing, and Controls

Placenta Derived Cells

Ethically accepted
Rich & Diverse
Highly potent Pro-angiogenic Immunoregulatory
Young donors
Unlimited source & Easy to collect
Over 25,000 Doses of 300 million cells per placenta The Placenta Project was

http://www.the-scientist.com/?articles.view/articleNo/43618/title/The-Prescient-Placenta/

Launched by the US National Institutes of Health (NIH) to further explore the role of the placenta in health and disease

From The Miracle of Birth to Therapeutics for All

Company Pipeline

Late-stage trials

* One Multinational trial- U.S- phase 3, Europe- via adaptive pathway potentially allowing early marketing approval

** Via PMDA's accelerated regulatory pathway for regenerative therapies

*** Pending FDA/EMA approval

A CHANGE IN REGULATORY ENVIRONMENT

Regulatory Status

		FDA		EMA		PMDA
CLI (PLX-PAD)	• •	Fast track approval Single pivotal study (n=246)	• • •	Adaptive regulatory pathway Single pivotal study (n=246) Potential conditional approval on interim report (n=123)	• •	Accelerated regulatory pathway Single pivotal study (n=75)
Hip fracture (PLX-PAD)	• •	Pivotal study Subject to FDA approval	• •	Adaptive regulatory pathway Single pivotal study

ARS (PLX-R18) Animal rule pathway
- Open communication, unlimited pre- IND

Reduces inflammation
Stimulates growth of collateral blood vessels
Stimulates repair of damaged muscle

Peripheral Arterial Diseases Orthopedic Injuries

PLX-PAD Mechanism of Action

Completed and Ongoing Clinical Studies with PLX-PAD

Two completed Phase I studies in Critical limb ischemia (CLI) in U.S. and Germany, N=27
- Good safety profile
- Trends of efficacy (pain reduction and increase in tissue perfusion)
Ongoing multinational Phase II study in Intermittent claudication (IC) in U.S., Germany, South Korea and Israel, N=172
- Enrollment completed
- Data readouts expected in H1 2018
Completed Phase II study in muscle injury following total hip replacement in Germany, N=20
- Good safety profile
- Strong efficacy (increase in muscle volume and muscle force)

Completed and Ongoing Clinical Studies with PLX-PAD

Ongoing multinational Phase III study In Critical Limb Ischemia (CLI) in U.S., Europe, N=246
- Fast track designation from FDA
- Adaptive regulatory pathway from EMA
- Support from EU Horizon 2020 program
Planned multinational Phase III study In Hip Fracture in U.S., Europe
- Adaptive regulatory pathway from EMA
- Support from EU Horizon 2020 program
Planned Pivotal study in CLI in Japan, N=75
- PMDA's accelerated regulatory pathway for regenerative therapies
- Form joint venture

Pre-Treatment

8 Weeks post treatment

Company Pipeline

Late-stage trials

* One Multinational trial- U.S- phase 3, Europe- via adaptive pathway potentially allowing early marketing approval

** Via PMDA's accelerated regulatory pathway for regenerative therapies

*** Pending FDA/EMA approval

Peripheral Arterial Disease (PAD)

PAD is caused by fatty deposits in leg arteries that obstruct blood flow
Intermittent claudication is the early stage while critical limb ischemia (CLI) is the more advanced stage of PAD
CLI Patients suffer from severe pain at rest, skin wounds, tissue necrosis and poor quality of life with a high risk of leg amputation and death
5-6 million people in U.S. and Europe suffer from CLI*
Estimated cost for treatment in the U.S. is over \$25 billion per year*
Up to 40% of patients are unsuitable for revascularization and experience up to a 40% amputation rate at 1 year**

*Source: Sage Group- (link, link, link)

**Source: European Society for Vascular Surgery (link)

CLI Phase III Study -U.S./ Europe (N=246)

Accelerated regulatory pathways in U.S. (Fast Track), Europe (Adaptive regulatory pathway) & Japan (accelerated regulatory pathway for regenerative therapies)
An interim analysis (N=123) of efficacy will be performed in support of an application to the EMA for Conditional Marketing Authorization (CMA)
Interim analysis could lead to CMA based on the success of either the primary or one of the key secondary endpoints, or a composite endpoint that includes death, major amputation, and certain measures of severity of wounds and gangrene
Primary endpoint is time to event (amputation or death); other measures of efficacy include AFS, quality of life, TcPO2, and pain score
Dosing regimen: two doses of 300 million cells, two months apart (n=144), placebo (n=72)
No HLA matching or immunosuppression required
Follow-up of 12-36 months increases the study's power allowing for a smaller trial

\$8 million grant from the EU Horizon 2020 program to support Phase III trial

Clinical Development of CLI in Japan

Accepted to the PMDA's accelerated regulatory pathway for regenerative therapies
A single 75 patient study may lead to early conditional marketing approval and reimbursement
Binding term sheet with Sosei CVC to establish joint venture for the clinical development and commercialization of PLX-PAD for CLI in Japan

Company Pipeline

Late-stage trials

* One Multinational trial- U.S- phase 3, Europe- via adaptive pathway potentially allowing early marketing approval

** Via PMDA's accelerated regulatory pathway for regenerative therapies

*** Pending FDA/EMA approval

Muscle Regeneration- clinical data

Muscle injury following total hip replacement (N=20)

Improvement of 500% P=0.0067

Improvement of 4000% P=0.012

Muscle Regeneration- clinical data

Muscle Injury following Total Hip Replacement (N=20)

Change in Volume from Day 0

Phase III Hip Fracture Study

Femoral neck fracture is the most common form of hip fracture
Annual treatment costs in the U.S. are estimated to be between \$10 to \$15 billion, and are expected to rise due to the aging population, with mortality rates of up to 36%*
Positive feedback from FDA and EMA on the proposed study design and endpoints of Phase III trial in treatment for muscle recovery following arthroplasty for hip fracture
PLX-PAD program in hip fracture might be eligible for Breakthrough Therapy designation and benefit from the 21st Century Cures Act as well as the EMA's Adaptive Pathways pilot project

\$8.7 million grant from the EU Horizon 2020 program to support this Phase III trial

* Source: Simran Mundi, Bharadwaj Pindiprolu, Nicole Simunovic, Mohit Bhandari

PLX-R18

Stimulates regeneration of damaged bone marrow to produce blood cells (white, red and platelets)

Acute Radiation Syndrome (ARS) Hematologic Indications

PLX-R18 Mechanism of Action

PLX-R18 Programs

Acute Radiation Syndrome (ARS)

In Preparations for pivotal study

Bone Marrow Failure

Following or in support of a transplant of hematopoietic stem cells (HCT) Ongoing Phase I study in U.S and Israel

Hematological Disorders

Autoimmune diseases, Genetic disorders, Chemotherapy, Radiation therapy, Side effects from treatments Covered by patent

Company Pipeline

Late-stage trials

* One Multinational trial- U.S- phase 3, Europe- via adaptive pathway potentially allowing early marketing approval

** Via PMDA's accelerated regulatory pathway for regenerative therapies

*** Pending FDA/EMA approval

Acute Radiation Syndrome ARS

ARS occurs following acute exposure to very high levels of radiation, and involves severe, potentially lethal injury to the bone marrow as well as to other organs and systems within the body

High doses of radiation can destroy the bone marrow's ability to produce white cells, red cells and platelets; without these cells patients are at high risk of death

Collaboration on ARS with U.S. Government

Studies are conducted and funded by the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) and U.S the department of defense

PLX-R18 Data- Phase I equivalent study (FDA animal rule)

PLX-R18 Data- Phase II equivalent study (N=62) (FDA animal rule)

PLX-R18- Treatment of ARS

Allogeneic, ready to use as an off the shelf product
Easy IM administration
Beneficial when administered even 48 hrs. following exposure to radiation
No need for prescreening no effect if injected to those who were not exposed to radiation
Supports recovery of all three blood lineages (red and white cells and platelets)
Long shelf life
Showed increased survival rates In irradiated non-human primates (NHPs)

PLX-R18 Hematological Program

Ongoing U.S. and Israeli Phase I clinical trial of R18 for the treatment of insufficient hematopoietic recovery following hematopoietic cell transplantation
- − N= up to 30
- − Open-label trial allows for interim data analysis
Collaboration with the to evaluate PLX-R18 as an adjuvant therapy to umbilical cord blood transplantation in animal studies
- − Grant of \$900,000 from Israel-U.S. Binational Industrial Research and Development Foundation (BIRD)
Granted European patent to cover indications related to the bone marrow's inability to produce blood cells, such as autoimmune diseases, genetic disorders, chemotherapy, radiation therapy, and side effects from other treatments

Commercialization Strategy

1. Out-licensing commercialization deals with partners
2. Direct sales of indications with small patients population & high market price
3. Direct sales of our PLX-R18 product for Acute Radiation Syndrome (governments)

	Indication	Deal structure
Collaborations	IC, CLI South Korea only	Joint Venture following marketing authorization by the South Korean authorities
Pluristem keeps IP and manufacturing rights in all collaborations	Acute Radiation Syndrome	U S National Institutes of Health (NIH) to examine the effectiveness of PLX - R18 as a treatment for ARS following 24 hoursfrom exposure
	Acute Radiation Syndrome	U S Department of Defense to examine the effectiveness of PLX - R18 prior to, and within the first 24 hours of exposure to radiation
	Acute Radiation Syndrome	Pluristem will contribute cells and scientific knowledge, FMU will conduct the studies and provide the required resources
	Acute Radiation Syndrome	Conducting trials to test PLX - R18 cells in the treatment of ARS and understanding of MOA
	CLI, Immunology, Cardiovascular, Orthopedic	Research to test the unique immunology of the placenta and cells MOA
39	Umbilical Cord Blood Transplantation	Evaluating PLX - R18 as an Adjuvant Therapy to Umbilical Cord Blood Transplantation

Investment

Late-stage pipeline with products advancing towards commercialization and 3rd parties funding
Advanced regulatory pathways that could shorten time to commercialization
Expected near-term data readouts
"Off the shelf" product, no HLA-matching required
Unique multifactorial MoA with a vast scientific background
Major technological competitive advantages
Strong collaborations and partnerships

Upcoming Milestones – 12 Months

Initiate pivotal trials

Critical limb ischemia (CLI) U.S., Europe (Japan yet to start)
Hip fracture U.S., Europe
ARS

Clinical data readout

Phase II Intermittent Claudication (IC)
Phase I incomplete engraftment of hematopoietic cell transplantation open label
Pivotal study in ARS

Business development

U.S. Advance discussions with U.S. government regarding stockpiling of PLX-R18 for ARS
Japan- Finalize joint venture
Asia Licensing/ joint venture with partner for Asian market