Pluri Inc. — Director's Dealing 2016

Jan 7, 2016

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Check this box if no longer subject to Section 16. Form 4 STATEMENT OF CHANGES IN BENEFICIAL or Form 5 obligations may continue. See Instruction 1 OWNERSHIP (b).

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person[*] 2. Issuer Name and Ticker or Trading Symbol 5. Relationship of Reporting Person(s) to Issuer PLURISTEM THERAPEUTICS (Check all applicable)

YANAY YAKY 0001402539 INC [ PSTI ] X Director 10% Owner (Last) (First) (Middle) X Officer (give title below) Other (specify below) 3. Date of Earliest Transaction (Month/Day/Year)

14 ARGAMAN ST. 01/05/2016 CFO, COO & President (Street) 4. If Amendment, Date of Original Filed 6. Individual or Joint/Group Filing (Check (Month/Day/Year) Applicable Line)

SHIMSHIT L3 17906 X Form filed by One Reporting Person Form filed by More than One Reporting

(City) (State) (Zip) Person

Table I – Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1. Title of Security (Instr. 3) 2. Transaction 2A. Deemed 3. 4. Securities Acquired 5. Amount of 6. 7. Nature of Date Execution Date, if Transaction (A) or Disposed Of (D) Securities Ownership Indirect (Month/Day/Year) any Code (Instr. (Instr. 3, 4 and 5) Beneficially Form: Beneficial (Month/Day/Year) 8) Owned Direct (D) Ownership Following or Indirect (Instr. 4) (A) Reported (I) (Instr. 4) Code V Amount or Price Transaction(s) (D) (Instr. 3 and 4) Common Stock 01/05/2016[(1)] A 150,000 A $0 1,451,616 D By Yaacov Common Stock 41,499 I Yanay Management Ltd.

Table II – Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of 2. 3. Transaction 3A. Deemed 4. 5. 6. Date Exercisable and 7. Title and 8. Price 9. Number 10. 11. Nature Derivative Conversion Date Execution Date, if Transaction Number Expiration Date Amount of of of Ownership of Indirect Security or Exercise (Month/Day/Year) any Code (Instr. of (Month/Day/Year) Securities Derivative Derivative Form: Beneficial (Instr. 3) Price of (Month/Day/Year) 8) Derivative Underlying Security Securities Direct (D) Ownership Derivative Securities Derivative (Instr. 5) Beneficially or Indirect (Instr. 4) Security Acquired Security (Instr. Owned (I) (Instr. (A) or 3 and 4) Following 4) Disposed Reported of (D) Transaction (Instr. 3, (s) (Instr. 4) 4 and 5) Amount or Number Date Expiration of Code V (A) (D) Exercisable Date Title Shares

Explanation of Responses:

1. The shares vest as follows: 25% after 6 months from grant and the remaining shares vest in 6 equal installments every 3 months thereafter. Remarks:

/s/ Yaky Yanay 01/07/2016 ** Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

• If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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