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PlantFuel Life Inc. Board/Management Information 2021

Apr 22, 2021

47216_rns_2021-04-22_e7683296-9a8b-4c6c-9263-8b58fbd1521d.pdf

Board/Management Information

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FORM 51-102F3 MATERIAL CHANGE REPORT

Item 1: Name and Address of Reporting Issuer

Sire Bioscience Inc. (the “ Company ”) 2500 Meadowpine Blvd, Unit 202 Mississauga, ON L5N 6C4

Item 2: Date of Material Change

April 16, 2021.

Item 3: News Release

A news release was issued and disseminated on April 16, 2021 and filed on SEDAR.

Item 4: Summary of Material Changes

The Company announced the resignation of Brian Nugent, as further described in Item 5 below.

Item 5: Full Description of Material Change

The Company announced that Brian Nugent has resigned as a member of the Company’s board of directors (the “ Board ”). It has been a pleasure and a blessing to have worked with Brian Nugent over the past few years, his business acumen and tremendous experience will certainly be missed, the Company wishes him nothing but the best in all his future endeavors.

Item 6: Reliance on subsection 7.1(2) or (3) of National Instrument 51-102

Not applicable.

Item 7: Omitted Information

None.

Item 8: Executive Officer

Brian Polla, CEO and COO T: 416.669.9392 E: [email protected]

Item 9: Date of Report

April 22, 2021.