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Photocure ASA

Annual Report Apr 17, 2019

3714_10-k_2019-04-17_8840166a-3bef-4bfd-b936-22a284af3c82.pdf

Annual Report

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Annual report 2018

ANNUAL GENERAL MEETING

Photocure ASA delivers transformative solutions to improve the lives of bladder cancer patients. Photocure's unique technology, making bladder cancer cells glow bright pink, has led to better health outcomes for bladder cancer patients. Photocure is headquartered in Oslo, Norway and listed on the Oslo Stock Exchange (OSE: PHO).

Photocure has transformed itself from a technology-based company to a therapeutic area-focused commercial stage pharmaceutical company with focus on bladder cancer. The allocation of resources, and hence expenses, have shifted from R&D to sales and marketing. Photocure's strategy is to maximize its commercial presence and the opportunity of its flagship brand Hexvix®/Cysview® in bladder cancer. In addition, the Company will continue to explore alone or in partnership with others new product opportunities that is complementary to the Company's commercial activities and expertise.

Content

  • 4 This year in brief
  • 6 Board of Directors Report 2018
  • 15 Confirmation from the Board of Directors and CEO 2018
  • 16 Board of Directors
  • 20 Corporate Governance Policy and Annual Review
  • 28 Statement of Comprehensive Income
  • 29 Statement of Financial Position
  • 30 Statement of Changes in Equity
  • 31 Statement of Cash Flows
  • 32 Accounting principles 2018
  • 40 Notes to the Financial Statements for 2018
  • 62 Independent auditor's report
  • 69 Alternative Performance Measures

2018

IN-MARKET UNIT SALES

P&L PHOTOCURE TOTAL

MNOK FY 2018 FY 2017
Hexvix / Cysview revenues 172.9 149.0
Other sales revenues 0.3 0.2
Signing fees and milestones 8.3 1.7
Total revenues 181.5 150.9
Gross profit 164.4 138.9
Operating expenses -174.9 -168.0
EBITDA recurring -10.5 -29.1
Restructuring and One-Off -14.2 -4.0
Depreciation & Amortization -13.2 -12.1
EBIT -37.9 -45.2
Profit/loss(-) before tax -36.7 -41.6
Net profit/loss(-) -36.7 -34.7

SALES REVENUE - MNOK

P&L PHOTOCURE BY SEGMENT

MNOK FY 2018 FY 2017
COMMERCIAL FRANCHISE
Nordic revenues 47.0 43.3
US revenues 63.7 42.4
Partner revenues 62.2 63.3
Hexvix/Cysview revenue 172,9 149.0
Other revenues 8.6 1.9
Total revenues 181.5 150.9
Gross profit 164.4 138.9
Operating expenses -156.0 -128.5
EBITDA recurring 8.4 10.4
DEVELOPMENT PORTFOLIO
Operating expenses -18.9 -39.5
EBITDA recurring -18.9 -39.5

in brief

Sales revenue increase of

Sales revenue for 2018 was 173 million.

Consolidated recurring EBITDA of

NOK MILL

An improvement from 2017 of NOK 19 million.

NOK MILL.

in CASH balance at year end.

Revenue growth of

in the U.S. operation

EBITDA

NOK8 MILL.

Significant investments in the U.S. operation

Reimbursement was extended and strengthened by CMS from 1 January 2019.

U.S. Cysview Commercial segment ®

U.S. FDA approved additional indications for BLC™* with Cysview® including use with flexible cystoscopy in the on-going surveillance of patients. *Blue Light Cystoscopy

Board of Directors Report 2018

We have in 2018 continued and strengthened our commercial activities within bladder cancer. We have focused our resources to revenue generating investments in U.S. driving significant revenue growth, while cost containment and restructuring has limited expense increases. The impact has been a significant improvement in operating results and a step forward to profitability. We have also strengthened the position of Hexvix®/Cysview® in the treatment of bladder cancer with the approval from U.S. Food and Drug Administration (FDA) of new indications, including surveillance, for Blue Light Cystoscopy with Cysview® and with the improved reimbursement decided by U.S. Centers for Medicare & Medicaid Services (CMS) effective from 2019.

The Company had sales revenues of NOK 173.2 million in 2018, an increase of 16% from 2017. Global full year in-market unit sales increased 5% in 2018, driven by a growth of 45% in the U.S. Overall, the Company has in 2018 seen operational improvements from 2017 driving significant improvements in earnings. Operating loss before restructuring costs was NOK 23.7 million, an improvement of NOK 21.5 million from 2017 operating loss of NOK 45.2 million. Net loss for the year was NOK 36.7 million compared to a loss in 2017 of NOK 34.7 million.

About Photocure

Photocure ASA ("Photocure", "the Company" or "the Group") delivers transformative solutions to improve the lives of bladder cancer patients. Photocure's unique technology, making bladder cancer cells glow bright pink, has led to better health outcomes for bladder cancer patients. Photocure is headquartered in Oslo, Norway and listed on the Oslo Stock Exchange (OSE: PHO).

Strategic direction – developing a specialty pharmaceutical company

Photocure has transformed itself from a technology-based company to a therapeutic area-focused commercial stage pharmaceutical company with focus on bladder cancer. The allocation of resources, and hence expenses, have shifted from R&D to sales and marketing. Photocure's strategy is to maximize its commercial presence and the opportunity of its flagship brand Hexvix®/Cysview® in bladder cancer. In addition, the Company will continue to explore alone or in partnership with others new product opportunities that is complementary to the Company's commercial activities and expertise.

Commercial Segment

HEXVIX®/CYSVIEW® – THE INNOVATIVE PRODUCT FOR IMPROVED DETECTION AND MANAGEMENT OF BLADDER CANCER

Photocure is leveraging its flagship brand Hexvix®/Cysview® for improved detection of non-muscle invasive bladder cancer, reduced disease recurrence and progression rates to improve

cost-effective health outcomes for bladder cancer patients. Hexvix®/Cysview® is marketed in the U.S. and Nordic by Photocure's own specialist commercial and medical teams and through partnerships in continental Europe, Canada and Australia/New Zealand. In 2018 the in-market sales totaled NOK 285 million, compared to NOK 256 million in 2017.

The Company continues to see significant growth opportunities in its markets and has a solid foundation for future growth of its breakthrough bladder cancer product, as well as exploring expansion of its product portfolio.

The company has continued to invest in its U.S. commercial organization, in line with its commercial market opportunities and strategic objectives. The added resources have driven growth in number of blue light cystoscopes installed at leading U.S. hospitals/ urology centers as well as growth in unit sales and revenue. Revenue in U.S. increased 53% in USD in 2018 to USD 7.8 million (NOK 63.7 million) while the installed base of blue light cystoscopes increased by 53 to a total of 157 at end of the year.

In addition to investments in the commercial capacity the growth has been fueled by approval of new indications, launch of the product in the surveillance setting and by improved reimbursement.

In February 2018, the U.S. Food and Drug Administration (FDA) approved additional indications for Blue Light Cystoscopy (BLC™) with Cysview® to include flexible blue light cystoscopes, which are used in the on-going surveillance of patients with bladder cancer. This new indication was granted based on the results from a large Phase 3 study completed in 2017. The clinical efficacy and safety profile was confirmed in this study and the label now allows repeated use of Cysview® and includes carcinoma in situ (CIS) lesions.

In May 2018, Photocure launched Cysview® in combination with blue light enabled flexible video cystoscopes from KARL STORZ, and the first bladder cancer patients underwent surveillance examination performed with flexible BLC™ with Cysview®.

In November 2018, the United States Centers for Medicare and Medicaid Services (CMS) released its final rule positively responding to Photocure's request by establishing an A9598 Code for Cysview® when used in the physician office and other sites of care effective 1 January 2019. In addition, CMS also issued complexity adjustment for certain BLC™ procedures performed in hospital outpatient departments continuing its complexity adjustment payment which has been in place since 1 January 2018. The BLC™ with Cysview® complexity

adjustment will result in an incremental payment of \$1,187 over white light cystoscopy payment effective 1 January 2019.

Sales revenue from Hexvix® in Nordic increased 9% in 2018 to NOK 47.0 million. In August 2018, Photocure signed an exclusive distribution agreement for the Nordic area with Combat Medical (www.combat-medical.com). The device is designed for the delivery of Hyperthermic Intra-Vesical Chemotherapy (HIVEC®) for non-muscle invasive bladder cancer and has a strong strategic and synergistic fit with our current business and customer call points. Photocure will leverage on the extensive Hexvix® infrastructure in the Nordic area for implementation of the Combat Medical distribution agreement. Commercial sales commenced the first quarter of 2019.

Partner revenue declined 2% to NOK 62.2 million, impacted by inventory build at Ipsen in 2017 and by IFRS 15 adopted from 1 January 2018 (see note 3 and 4 to the accounts). In-market unit sales were at level with 2017.

Hexvix®/Cysview® has been launched in Canada and Australia, however volumes have been negatively impacted by the timing

of the placement of scopes by third-party suppliers and health system funding approvals.

During 2018, several studies were published highlighting and confirming key benefits of Hexvix®/Cysview®. Main publications and presentations are: In March and May, new clinical data on Hexvix®/Cysview® was presented at the 2018 Annual European Association of Urology (EAU) Congress and American Urological Association (AUA) Congress respectively. In April, a new study BLC™ with Hexvix® using the KARL STORZ flexible video cystoscope system in the outpatient setting for the laser treatment of low-grade bladder tumors was published in the Scandinavian Journal of Urology. In May, positive results from the U.S. BLC™ with Cysview® registry were published in the Urologic Oncology Journal. Data from the publication showed that BLC™ with Cysview® significantly increases detection rates of flat, aggressive carcinoma in situ lesions (CIS) and papillary lesions compared to white light cystoscopy alone and can result in upstaging or upgrading in about 14% of patients and that repeat use is safe. In July, the Patient Reported Outcomes (PRO) with BLC™ with Cysview® study was published online in the British Journal of Urology International.

Development Portfolio

VISONAC® – TREATMENT OF MODERATE TO SEVERE ACNE CEVIRA® – TREATMENT OF HPV AND PRECANCEROUS LESIONS OF THE CERVIX

Photocure has been developing two new late stage clinical products.

Visonac® has the potential to satisfy a high unmet medical need for a large acne patient population in need for alternatives to antibiotics and isotretinoin. Acne is the single most common skin disease worldwide, and affects up to 85% of all 12-24 year olds. Visonac® is being developed as the first photodynamic therapeutic option for this large patient population, which can easily be administered in dermatology offices.

Cevira® is a unique, non-invasive photodynamic therapy under development for the treatment of oncogenic human papilloma virus (HPV) infection. Cervical HPV and precancerous lesions of the cervix are highly prevalent diseases affecting an estimated 260 million women across the globe. The current treatment option is surgery, which carries increased risk of preterm miscarriage. Cevira® is being developed as the first novel nonsurgical therapeutic option for this large and growing patient population.

Both Visonac® and Cevira® have shown medically relevant and statistically significant efficacy in multiple phase 2 studies in the target patients.

Based on this data, Photocure has obtained alignment with the FDA for both Visonac® and Cevira® on the phase 3 clinical development program through the Special Protocol Assessment (SPA) process. Photocure will continue assessing further strategic alternatives for Visonac® and Cevira®.

Financial review

The Photocure annual accounts have been prepared in accordance with IFRS requirements as adopted by EU.

Total revenue reached NOK 181.5 million up from NOK 150.9 million in 2017. Revenue growth was mainly driven by positive developments in U.S., but also revenues from Nordic as well as milestone revenues increased. Revenue has been impacted by adoption of IFRS 15 which is made effective for annual reporting periods beginning on or after 1 January 2018 (see note 3 and 4 to the accounts).

Sales revenues reached NOK 173.2 million in 2018, an increase of NOK 24.0 million from NOK 149.2 million in 2017. Sales revenues comprise own sales of Hexvix® in the Nordic region and Cysview® in the U.S. and income from product sales and royalties from Photocure's license partners on sales of Hexvix® to hospitals and pharmacies.

Signing and milestone revenues totaled NOK 8.3 million in 2018 compared to NOK 1.7 million in 2017. Signing and milestone revenues include milestones from Bellus Medical totaling NOK 4.9 million in 2018 and NOK 1.7 million in 2017. Furthermore, the revenues in 2018 include NOK 3.4 million from the partner agreement with Ipsen.

Operating expenses excluding restructuring expenses increased from NOK 184.1 million in 2017 to NOK 188.1 million in 2018. Main cost driver was the strategic investment in increased sales and marketing expenses in the U.S. sales operation, partly offset by reduced research and development expenses and other operating expenses. Photocure has expensed all research and development costs except for development costs related to the phase 3 clinical study for Cysview® which have been capitalized as intangible assets.

Photocure's operating result excluding restructuring expenses was NOK -23.7 million in 2018, compared to an operating result of NOK -45.2 million in 2017. The improvement in the operating result is primarily attributable to the significant increase in revenue combined with a modest increase in operating expenses.

Net financial items totaled NOK 1.2 million in 2018, compared to NOK 3.6 million in 2017. The reduced net financial income in 2018 was driven by less interest income and less foreign exchange gains than in 2017.

Result before tax was a loss of NOK 36.7 million in 2018 compared to a loss of NOK 41.6 million in 2017.

Tax income was NOK 6.9 million in 2017 and NOK 0.0 million in 2018. The calculation of deferred tax at year end was based on a tax rate of 22% in 2018 compared to 23% for 2017.

The Group's net result after tax was NOK -36.7 million in 2018 compared to NOK -34.7 million in 2017.

Net cash flow from operating activities was NOK -24.1 million in 2018, compared to NOK -23.6 million in 2017. 2018 net change in cash was NOK -22.5 million, an improvement of NOK 17.3 million from 2017. The improvement is mainly driven by reduced investments and proceeds from share issue.

Photocure follows a low risk investment strategy for its liquid funds. The return on the liquid funds depends on the rate of interest in the money markets and will therefore vary over time. Liquid funds amounted to NOK 106.8 million at 31 December 2018 and NOK 129.4 million at 31 December 2017.

Shareholder equity was NOK 176.3 million at 31 December 2018, an equity ratio of 76%. At the end of 2017, shareholder equity was NOK 218.1 million (83%).

DIVIDEND

The Board does not propose a dividend payment for 2018. Photocure is focusing its resources on building a specialty pharma company and the Board of Directors will recommend payment of dividends in line with the Company's results, financial position, product and market development plans and outlook. Photocure does not expect to pay dividends in the near future.

PARENT COMPANY

Photocure ASA (parent company) had in 2018 a profit after tax of NOK 1.7 million, compared to a loss after tax of NOK 27.7 million in 2017. The equity in Photocure ASA totals NOK 444.2 million at 31 December 2018. The equity ratio of the parent company is 91%.

SHARE CAPITAL AND BOARD MANDATES

At 31 December 2018, 21,779,008 shares were registered in Photocure. At the Ordinary General Meeting 9 May 2018, the Board of Directors was granted authorization to purchase up to 10% of its own shares. At 31 December 2018, Photocure held 14,930 own shares.

GOING CONCERN

Pursuant to § 3.3 (a) of the Norwegian Accounting Act, it is confirmed that the conditions for assuming that the Group is a going concern are present, and that the financial statements have been prepared on the basis of this assumption. No events have occurred since the end of 2018, except those which are stated in this report that are of major significance for the assessment of the Company's financial position and results.

Operational risk

Photocure develops innovative products and markets and sells these products through its own commercial teams and in partnerships with other companies. These activities entail exposure to various risks. The Board of Directors and management monitor and analyze the operations and potential risk factors, and actively take risk reduction measures.

COMMERCIAL RISK

Photocure is commercializing Hexvix®/Cysview® directly in the U.S. and the Nordic region, and has a strategic partnership with Ipsen for the commercialization of Hexvix® in Europe, excluding the Nordic region, and with Juno Pharmaceuticals and BioSyent Pharma for Australia/New Zealand and Canada respectively. Any significant event that adversely affects revenues from Hexvix®/ Cysview® could have a material and negative impact on Photocure's results and cash flows. Key commercial risks include:

  • Partners ability to support the brand in key markets.
  • Reimbursement may be limited or unavailable in certain markets, which could make it more difficult to achieve profitability in these markets. Changes in reimbursement in the E.U. and U.S. may have a material impact on Photocure's results and cash flows.

  • Use of Hexvix®/Cysview® requires installation of Blue Light Cystoscopes which are manufactured and sold by other companies. These companies' ability and willingness to develop and promote these products may affect Photocure's results and cash flows.

  • The expiration or loss of patent protection may adversely affect Photocure's future results and cash flows. Third parties may challenge or seek to invalidate or circumvent Photocure's patents and patent applications.
  • Competitive products or technologies may emerge at any time, and changes in the competitive landscape may have a material impact on Photocure's results and cash flows.

MANUFACTURING RISK

Delays or interruptions at the production facilities may impair supply of Hexvix®/Cysview® to the market and hence revenues.

DEVELOPMENT AND REGULATORY RISK

Photocure has currently two products under development, Visonac® and Cevira®. Key development risks include:

  • Development of Photocure's products is associated with inherent risk. Inter alia, development is subject to obtaining adequate funding as well as technological risks.
  • The further development of Photocure's near-term pipeline will depend on partnering agreements with third parties.

  • Photocure or its future partners will need approval from regulatory authorities to market its pipeline products. Efficacy issues could arise and approval may be denied, delayed or limited.

  • Successful launches and sales for pipeline products may not be achieved inter alia due to changes in market dynamics or competition, unsuccessful marketing, and pricing pressure due to limitations on healthcare budgets.
  • As with any drug intended for diagnostic or therapeutic use, adverse clinical reactions are always a possibility.

Financial risk

Photocure has an international business operation and is exposed to currency risk, interest rate risk, commodity price risk, liquidity risk and credit risk. At the end of 2018, the Company had no derivatives or other financial instruments to reduce these risks.

Responsibility for managing financial risk is placed with the management of the Company. Financial risk is also monitored by the Board of Directors.

INTEREST RATE RISK

Photocure does not have any interest-bearing debt, and the Company's interest rate risk is mainly associated with the Company's holdings of cash and cash equivalents. The main strategy is to diversify the risk and invest in money market funds and bond funds with low risk, high liquidity and short duration. The investments are denominated in NOK.

LIQUIDITY RISK

The Company monitors the cash flows from both long and short-term perspectives through planning and reporting. Photocure does not have any loan agreements that involve covenants or other financial requirements. Photocure uses a multi-currency consolidated accounts system that provides flexibility in relation to drawing on multiple currencies.

CREDIT RISK

Photocure is primarily exposed to credit risk associated with accounts receivable and other short-term receivables. Photocure's sales are mainly to license partners, pharmaceutical wholesalers in the Nordic region and hospitals in the U.S. The credit risk is limited as the counterparties are mainly large companies/hospitals that are not related to each other. Photocure's credit risk is considered moderate and the Company does not use credit insurance.

CURRENCY RISK

As NOK is the Company's presentation currency, Photocure is exposed to translation risk associated with the Company's net exposure in foreign currency. Photocure's revenues and costs are accrued in different currencies and the Company is therefore exposed to exchange rate fluctuations. The Company monitors the need for hedging of large transactions on an ongoing basis. Photocure did not have outstanding hedging of future transactions at 31 December 2017 and 31 December 2018.

Organization

The Group's senior management team at year-end consists of Daniel Schneider, President and CEO; Erik Dahl, Chief Financial Officer; Grete Hogstad, Vice President Strategic Marketing; Inger Ferner Heglund, Vice President Research and Development; Gry Stensrud, Vice President Technical Development and Operations; Ambaw Bellete, Head, U.S. Cancer Commercial Operations and Espen Njåstein, Head, Nordic Cancer Commercial Operations.

The Board of Directors held 19 meetings in 2018. All members of the Board of Directors are shareholder-elected. The members of the Board of Directors were at the end of 2018 Jan H. Egberts (Chairperson), Johanna Holldack, Gwen Melincoff, Tom Pike, Synne H. Røine and Grannum R. Sant.

Photocure ASA has offices in Oslo, Norway. Photocure ASA has one subsidiary, Photocure Inc, located in Princeton, New Jersey, USA.

Corporate social responsibility

Photocure's corporate social responsibility guidelines are available on www.photocure.com.

Photocure is a specialty pharma company that delivers transformative solutions for detecting and treating bladder cancer to improve the lives of patients. The Company consistently aims to create innovative drugs, procedures and medical devices that help urology providers deliver improved bladder cancer outcomes to their patients. Through Photocure's end-to-end insight and bladder cancer expertise, the Company provides smarter solutions to existing challenges and are shaping the future of bladder cancer treatment.

Photocure believes that creating value for patients, customers and society strengthens the Company's business and provides value for shareholders, and that the commitment to corporate social responsibility will enhance this by building strong relationships with stakeholders.

Photocure's commitment to corporate social responsibility is driven by the Company values – care, courage and passion – and is reflected in the focus on the following priority areas: Patients access to health and quality of life, human resources, environment, governance and ethics.

PATIENTS ACCESS TO HEALTH AND QUALITY OF LIFE

Photocure's mission is to deliver transformative solutions to improve the lives of bladder cancer patients.

This mission encompasses all activities from developing products, gaining approval by relevant authorities, working with patient organizations and hospitals and finally getting the products to the market either through Photocure's own sales organization or by partners.

Through efforts made by Photocure and its partners, more bladder cancer patients gained access to Hexvix®/Cysview® and its possible positive impact on management of these patients. The Company is continuously supporting clinical studies.

Documented clinical benefits for bladder cancer patients using Hexvix®/Cysview® have been published in Scandinavian Journal of Urology, Urologic Oncology Journal and British Journal of Urology International this year. Since launch over 500,000 procedures have been conducted with Hexvix®/Cysview® worldwide.

HUMAN RESOURCES

The Photocure organization comprised of 71 employees in Nordic and the U.S. at the end of 2018. In addition, the Company has a strong network of consultants to support the operations and the development of the pipeline products. The Company's policy is to outsource non-core operations and highly specialized services. The work environment within the Company is considered to be good. No accidents or injuries resulting in absence were registered in 2018. Absence due to illness in the Company was 3.6% of total hours in 2018.

Photocure aims to be a workplace with equal opportunities in all areas. The Company has traditionally recruited from environments where the number of women and men is relatively equally represented. In terms of gender equality within the Company, 50% of board members are women, as are 43% of the senior management team at the end of 2018. Working time arrangements at the Company are independent of gender.

Photocure's policy is to promote equal rights and opportunities and prevent discrimination based on gender, ethnicity, nationality, sexual orientation, ancestry or religion. Photocure is working actively to promote the anti-discrimination act. These activities include recruitment, salary and working conditions, promotion, professional development and protection against harassment.

Photocure aims to be a workplace where there is no discrimination on the basis of disability. Photocure works actively to design and facilitate the physical environment so that the Company's various functions can be used by as many as possible.

ENVIRONMENT

The Company does not pollute the external environment to a greater extent than is normal for this type of industry. All production and distribution is outsourced. In selection of suppliers, ethical and responsible business conduct including environment, health and safety policy of the supplier is evaluated.

GOVERNANCE AND ETHICS

Ensuring good governance practices involves all people in Photocure. This includes governance as documented in the guidelines for corporate governance, ethical conduct and anticorruption based on the Photocure values and respect for human rights. Photocure's supplier requirements in terms of adherence to Company practices, guidelines and values are an integral part of all stages of the procurement process including selection and auditing.

Photocure's values set out the expectation that everyone behaves ethically in everything they do. The Company values are care, courage and passion. The annual performance appraisal for Photocure employees and management includes an assessment of the performance in relation to the values.

Photocure considers solid corporate governance as a prerequisite to creating value for shareholders and gaining the confidence of investors. Photocure will strive to comply with the generally

accepted principles of good corporate governance through its internal controls and management structure. Photocure believes that its current guidelines for corporate governance are in line with the latest version of the Norwegian Code of Practice for Corporate Governance, and a description of this is given in the annual report. A complete description of the recommendation is available at the Norwegian Corporate Governance Board (NCGB) web pages (www.nues.no).

Subsequent events

Photocure is not aware of any events after year-end that would be of significance to the financial statements for the year ended 31 December 2018.

Outlook

Photocure has built considerable experience in the bladder cancer market through its Hexvix®/Cysview® franchise and sees significant long-term value creation potential in this market segment. The company aims to capitalize on a number of factors including inclusion in the AUA-SUO guidelines, increased patient awareness and the improved reimbursement of Cysview®. These drivers will significantly increase penetration in the U.S. market. Furthermore, with the approval of Cysview® to be used with flexible cystoscopes, a significant market opportunity has opened in the surveillance segment.

Given the large untapped market opportunities, the company will continue to invest in the U.S. commercial and medical infrastructure in 2019. Photocure is fully funded for this market strategy.

The company maintains its 2020 forecasted revenue range of USD 20-25 million in the U.S., up from USD 7.8 million in 2018, and sees significant continued revenue growth and profit opportunities in the U.S. market beyond 2020.

Along with our partner KARL STORZ, we have doubled the number of installed blue light cystoscopes in the U.S. since 2016. We believe the continued strong installation growth rates will drive future revenue growth for Cysview®. Key to our continued success is the acceleration and adoption of the newly approved flexible Blue Light Surveillance Cystoscopy with Cysview® performed in the larger surveillance market.

We will expand the number of customer facing roles by 50% early 2019. This will help drive blue light cystoscope installations in coordination with our partner KARL STORZ and increase the number of patients treated with Cysview® per installed scope in all settings of care. The increase in commercial footprint will to a large extent be achieved by re-purposing existing headcount to sales and thereby limit the overall increase in headcount.

The improved permanent reimbursement rates in U.S. went into effect 1 January 2019 and will provide physicians the ability to use Cysview® in Blue Light Cystoscopy procedures on the majority of their patients without negatively affecting their practice economics.

Recent bladder cancer patient survey data confirms that there is growing awareness and patient demand for Blue Light Cystoscopy with Cysview®. Patients are now actively seeking treatment centers who offer Cysview® and Blue Light Cystoscopy.

Our future growth rates will also be significant and sustainable through continued investment and focused execution.

Oslo, 16 April 2019 The Board of Directors of Photocure ASA

Jan H. Egberts Chairperson

Tom Pike Director

Johanna Holldack Director

Synne H. Røine Director

Gwen Melincoff Director

Grannum R. Sant Director

Daniel Schneider President and CEO

Confirmation from the Board of Directors and CEO 2018

We confirm that, to the best of our knowledge, that the financial statements for the period from 1 January to 31 December 2018 have been prepared in accordance with IFRS adopted by EU and gives a true and fair view of the Group and the Company's consolidated assets, liabilities, financial position and results of operations, and that the Report of the Board of Directors provides a true and fair view of the development and performance of the business and the position of the Group and the Company together with a description of the key risks and uncertainty factors that the Company is facing.

Oslo, 16 April 2019 The Board of Directors of Photocure ASA

Jan H. Egberts Chairperson

Tom Pike Director

Johanna Holldack Director

Synne H. Røine Director

Gwen Melincoff Director

Grannum R. Sant Director

Daniel Schneider President and CEO

Board of Directors

Jan H. Egberts

Chairperson of the Board/Member of Compensation Committee Attendance: Board meetings: 18/19 Compensation Committee: 4/4

Jan H. Egberts holds 14,500 shares and no share options in Photocure.

Dr. Egberts has over 30 years of experience in the pharmaceutical and medical devices sector. Currently, Dr. Egberts serves as the Managing Partner of Veritas Investments, a private investment company focused on investments in the healthcare industry. Previous positions include strategic consultant at McKinsey & Co. in New York, various business development and general management positions of increasing responsibilities in the USA at Merck & Co., Johnson & Johnson and Molnlycke Health Care, Senior Industry Advisor, Healthcare Investments for 3i, CEO of OctoPlus, a publicly traded specialty pharmaceutical company in the Netherlands, and CEO of Agendia, a molecular diagnostics company.

  • Elected year 2017
  • Position: Managing Partner of Veritas Investments
  • Education: MD and MBA
  • Other assignments: Board member at Pharming, Nordic Nanovector, Viroclinics, LeadPharma, CHDR, SigmaScreening, NLC Investments and Mellon Medical

Johanna Holldack

Director

Attendance: Board meetings: 18/19

Johanna Holldack holds no shares and no share options in Photocure.

Dr. Holldack has international operational experience from pharma companies, including clinical trials, drug approvals, IPOs and licensing. She has also managed several mergers and acquisitions. In addition, Dr. Holldack has venture capital experience from Swiss-based Aravis Venture where she was a partner for 5 years. Her industry career spans over 20 years including management and executive positions at Behringwerke, Chiron, MediGene, Borean Pharma, Telormedix and Trethera Corporation.

  • Elected year 2017
  • Position: Independent consultant
  • Education: MD
  • Other assignments: Chairperson at Amal Therapeutics

Gwen Melincoff

Director/Member of the Audit Committee Attendance: Board meetings: 18/19 Audit Committee: 5/5

Gwen Melincoff holds 1,000 shares and no share options in Photocure.

Gwen Melincoff has over 25 years of leadership experience in the biotechnology and pharmaceutical industries. From 2014 to 2016, she served as Vice President of Business Development at BTG International Inc., and from 2004 to 2013, she was Senior Vice President of Business Development at Shire Pharmaceuticals. Additionally, she led the Strategic Investment Group (SIG), Shire's \$50MM corporate venture fund which was started in 2010.

  • Elected year 2017
  • Position: Independent consultant
  • Education: B.S in Biology, M.Sc. in Management
  • Other assignments: Board member at Collegium Pharmaceutical Inc., Venture Advisor at Agent Capital.

Tom Pike

Director/Chairperson of the Compensation Committee Attendance: Board meetings: 19/19 Compensation Committee: 4/4

Tom Pike holds 3,400 shares and no share options in Photocure.

Tom Pike serves as Chairperson of Vaccibody, and has been associated with the pharmaceutical industry in Norway for many years. Previous positions include Partner in the venture capital fund NeoMed, Chairperson & CEO of Clavis Pharma ASA as well as Chairperson of the Association of the Pharmaceutical Industry in Norway. He has worked at Hoffman La-Roche in Norway and Switzerland for 18 years, including 8 years as general manager in Norway.

  • Elected year 2014
  • Position: Life Science Industry Professional
  • Education: B.Sc. Honors in Pharmacology
  • Other assignments: Chairperson at Vaccibody AS, Clanotech AB, ACD Pharmaceuticals AS, Kaydence AS and Credio AS. Board member at Vectron Biosolutions AS and Vingmed Holding AS

Synne H. Røine

Director/Chairperson of the Audit Committee Attendance: Board meetings: 18/19 Audit Committee: 4/5

Synne H. Røine holds no shares and no share options in Photocure.

Synne H. Røine is Partner at Serendipity Partners, a private investment company focused on healthcare. Ms. Røine served as CFO of Colosseum Dental Group from 2015 to 2017, a leading provider of dental care in Europe, and as CFO of Bionor Pharma ASA from 2013 to 2015, a biotechnology company developing therapeutic vaccines against viral diseases. From 2009 to 2013 she was CFO of Pronova BioPharma ASA, which develops and sells Omega-3 based pharmaceuticals.

  • Elected year 2014
  • Position: Partner at Serendipity Partners
  • Education: M.Sc.

Grannum R. Sant

Director/Member of the Audit Committee Attendance: Board meetings: 19/19 Audit Committee: 5/5

Grannum R. Sant holds no shares and no share options in Photocure.

Dr. Sant has a broad and deep international experience in pharma and academia. From 2003 to 2013 he held senior leadership roles including Vice President and Head of Medical Affairs for urology and oncology at Sanofi US. His last pharma position (2010-2013) was as Vice President, Head of Global Medical Affairs Rare Genetic Diseases at Genzyme. Dr. Sant is a board-certified urologist in the US and prior to 2003 was Professor and Chair of the Urology at Tufts University School of Medicine.

  • Elected year 2016
  • Position: Independent consultant and Professor of Urology at Tufts University School of Medicine in Boston, USA
  • Education: MD (Dublin University), FRCS, FACS
  • Other assignments: Board Member Cellanyx and Xennials Therapeutics, Scientific Advisory Board Cellanyx and EmpiraMed

Corporate Governance Policy and Annual Review

Review of policy adopted by the Board 16 April 2019

Photocure is committed to Good Corporate Governance

Photocure ASA ("Photocure" or the "Company") has made a strong commitment to ensure trust in the Company and to enhance shareholder value through effective decision-making and improved communication between the management, the board of directors and the shareholders. The Company's framework for corporate governance is intended to decrease business risk, maximize value and utilize the Company's resources in an efficient, sustainable manner, to the benefit of shareholders, employees and society at large.

The Company will seek to comply with the Norwegian Code of Practice for Corporate Governance (the "Corporate Governance Code"), last revised on 17 October 2018 and available at the Norwegian Corporate Governance Board's web site www.nues.no, to the extent not considered unreasonable due to the Company size and stage of development. The principal purpose of the Corporate Governance Code is (i) to ensure that listed companies implement corporate governance that clarifies the respective roles of shareholders, the board of directors

and senior management more comprehensively than what is required by legislation and (ii) to ensure effective management and control over activities with the aim of securing the greatest possible value creation over time in the best interest of companies, shareholders, employees and other parties concerned.

The Company is subject to reporting requirements for corporate governance under the Accounting Act section 3-3b as well as Oslo Børs "Continuing obligations of stock exchange listed companies" section 7. The board of directors will include a report on the Company's corporate governance in each annual report including an explanation of any deviations from the Corporate Governance Code. The corporate governance framework of the Company is subject to annual reviews and discussions by the board of directors.

The following provides a discussion of the Company's corporate governance in relation to each section of the Corporate Governance Code for the financial year 2018. Photocure's compliance with the Code is detailed in this report and section numbers refer to the Corporate Governance Code:

1. Implementation and reporting on Corporate Governance

The Company will seek to comply with the Corporate Governance Code. The board of directors shall include a report on the Company's corporate governance in its annual report, including an explanation of any deviations from the Corporate Governance Code.

Non-conformance with the recommendation: None

2. Business

Photocure's business is clearly defined in the Company's articles of association (the "Articles of Association"). The Company's objectives, strategies and risk profiles should be evaluated at least annually to create value for shareholders. Objectives and strategies are presented in the annual report and the Company's website www.photocure.com.

The Company's business is defined in the following manner in the Articles of Association section 3:

"The purpose and main business of the Company is to operate business related to medical use of photodynamic technology and other medical methods of treatment, and anything thereby connected."

The board of directors of the Company has adopted several corporate governance guidelines, including rules of procedure for the board of directors, instructions for the audit committee, instructions for the compensation committee, insider manuals, manual on disclosure of information and guidelines for corporate social responsibility.

Non-conformance with the recommendation: None

3. Equity and dividends

CAPITAL STRUCTURE

At 31 December 2018, the Company's consolidated equity was NOK 176.3 million, an equity ratio of 76%. The board of directors considers this equity level to be satisfactory. The company had at 31 December 2018 no interest-bearing debt. The Company's capital structure and financial strength is continuously considered in light of its objectives, strategy and risk profile.

DIVIDEND POLICY

Photocure is focusing its resources on building a specialty pharma company and the board of directors will recommend payment of dividends in line with the Company's results, financial position and outlook. The Company has, due to its level of development, uneven revenue streams and net cash flows, and does not expect to pay recurring dividends until justified by recurring cash flows. The dividend policy is disclosed in the annual report.

The ordinary general meeting resolves the annual dividend, based on the proposal by the board of directors. The amount proposed sets an upper limit for the general meeting's resolution.

CAPITAL INCREASES AND ISSUANCE OF SHARES

The board of directors' is authorized by the general meeting to resolve increases of the Company's share capital. The authorization is restricted to defined purposes, and does not last longer than to the Company's next annual general meeting.

PURCHASE OF OWN SHARES

The board of directors is authorized by the general meeting to purchase the Company's own shares on behalf of the Company.

The authorization is restricted to defined purposes, and does not last longer than to the Company's next annual general meeting.

Non-conformance with the recommendation: None

4. Equal treatment of shareholders and transactions with related parties

PRE-EMPTION RIGHTS TO SUBSCRIBE

According to the Norwegian Public Limited Liability Companies Act, the Company's shareholders have pre-emption rights in share offerings against cash contribution. Such pre-emption rights may however be set aside, either by the general meeting or by the board of directors if the general meeting has granted a board authorization which allows for this. Any resolution to set aside pre-emption rights will be justified by the common interests of the Company and the shareholders, and such justification will be publicly disclosed through a stock exchange notice from the Company.

Courtesy of Dirk Zaak, Associate Professor, Dep. of Urology; University of Munich

TRADING IN OWN SHARES

Photocure owns a total of 14,930 own shares. Photocure has acquired 14,121 own shares during 2018.

In the event of a future share buy-back program, the board of directors will aim to ensure that all transactions pursuant to such program will be carried out either through the trading system at Oslo Børs or at prevailing prices at Oslo Børs. In the event of such program, the board of directors will take the Company's and shareholders' interests into consideration and aim to maintain transparency and equal treatment of all shareholders. If there is limited liquidity in the Company's shares, the Company shall consider other ways to ensure equal treatment of all shareholders.

TRANSACTIONS WITH CLOSE ASSOCIATES

The board of directors aim to ensure that any future transactions between the Company and shareholders, a shareholder's parent Company, members of the board of directors, executive personnel or close associates of any such parties are entered into on arms-length terms. For any such transactions which do not require approval by the general meeting pursuant to the Norwegian Public Limited Liability Companies Act, the board of directors will on a case-by-case basis assess whether a fairness opinion from an independent third party should be obtained.

Non-conformance with the recommendation: None

5. Shares and negotiability

The shares of the Company are freely transferable. There are no restrictions on ownership, trading and voting for shares in the Company pursuant to the Articles of Association.

Non-conformance with the recommendation: None

6. General meetings

The board of directors will make its best efforts with respect to the timing and facilitation of general meetings to ensure that as many shareholders as possible may exercise their rights by participating in general meetings, thereby making the general meeting an effective forum for the views of shareholders and the board of directors.

NOTIFICATION

The notice for a general meeting, with reference to or attached support information on the resolutions to be considered at the general meeting, shall as a principal rule be sent to shareholders individually, or to their depository banks, no later than 21 days prior to the date of the general meeting. The notice of meeting includes information regarding shareholders' rights, guidelines for registering and voting at the meeting.

The board of directors will seek to ensure that the resolutions and supporting information distributed are sufficiently detailed and comprehensive to allow shareholders to form a view on all matters to be considered at the meeting. The notice and support information, as well as a proxy voting form, will normally be made available on the Company's website www.photocure.com no later than 21 days prior to the date of the general meeting.

PARTICIPATION AND EXECUTION

Pursuant to the Articles of Association section 9 shareholders who want to participate at the general meeting shall notify the Company thereof within five days prior to the general meeting.

To the extent deemed appropriate or necessary, the board of directors will seek to arrange for the general meeting to vote separately on each candidate nominated for election to the Company's corporate bodies.

The chairperson of the board, the chief executive officer and the chief financial officer shall, as a general rule, be present at the annual general meeting. The board of directors and the chairperson of the nomination committee shall, as a general rule, be present at general meetings. The auditor should attend the ordinary general meeting and any extraordinary general meetings to the extent required by the agenda items or other relevant circumstances.

The chairperson of the board will normally be chairing the general meetings. The board of directors will seek to ensure that an independent chairperson is appointed if considered necessary based on the agenda items or other relevant circumstances.

The Company will aim to prepare and facilitate the use of proxy forms which allow separate voting instructions to be given for each item on the agenda, and nominate a person who will be available to vote on behalf of shareholders as their proxy.

Non-conformance with the recommendation: Photocure is a small company and with directors living abroad, the Company has so far not required directors´ attendance in general meetings.

7. Nomination Committee

The nomination committee is governed by the Articles of Association section 7. In addition, the Company's general meeting adopts instructions for the nomination committee. The nomination committee shall consist of two or three members who shall be shareholders or shareholder representatives. The members shall be elected by the general meeting for a term of one year. The nomination committee shall give its recommendation to the general meeting on election of and compensation to members of the board of directors and members of the nomination committee. The proposals shall be justified.

Shareholders are encouraged to submit proposals to the nomination committee for candidates for election to the board of directors. Such proposals must be in writing and justified and be submitted minimum 2 months before the general meeting if they are to be considered by the nomination committee.

Resected Tumor Blue / White

Courtesy of Dirk Zaak, Associate Professor, Dep. of Urology; University of Munich

The nomination committee currently consists of the following three members: Hans Peter Bøhn (chairperson), Dan Mahoney, and James McDonald. The current members have been elected by the general meeting with a term until the Company's ordinary general meeting in 2019. All members are independent of the board of directors and senior management.

Non-conformance with the recommendation: None

8. Composition and independence of the Board of Directors

Pursuant to the Articles of Association section 5, the Company's board of directors shall consist of three to seven members. The board of directors currently consists of the following six members: Jan H Egberts (chairperson), Johanna Holldack, Gwen Melincoff, Tom Pike, Synne H. Røine and Grannum R. Sant. The chairperson of the board has been elected by the general meeting. The term of office for members of the board of directors is one year at a time.

All members of the board are considered independent of the Company's senior management, material business contacts and the Company's main shareholders.

The Company's annual report provides information to illustrate the expertise of the members of the board of directors and their record of attendance at board meetings.

Non-conformance with the recommendation: None

9. The work of the Board of Directors

THE RULES OF PROCEDURE FOR THE BOARD OF DIRECTORS

The board of directors is responsible for the over-all management of the Company, and shall supervise the Company's day-to-day management and the Company's activities in general.

The Norwegian Public Limited Liability Companies Act regulates the duties and procedures of the board of directors. In addition, the board of directors has adopted supplementary rules of procedures, which provides further regulation on inter alia the duties of the board of directors and the chief executive officer, the division of work between the board of directors and the chief executive officer, the annual plan for the board of directors,

notices of board proceedings, administrative procedures, minutes, board committees, transactions between the Company and the shareholders and confidentiality.

The board shall produce an annual plan for its work, with particular emphasis on objectives, strategy and implementation. The chief executive officer shall at least once a month, by attendance or in writing, inform the board of directors about the Company's activities, position and profit trend.

The board of directors' consideration of material matters in which the chairperson of the board is, or has been, personally involved, shall be chaired by some other member of the board.

The board of directors shall evaluate its performance and expertise annually, and make the evaluation available to the nomination committee.

The board of directors has adopted rules of procedures for the board of directors, which inter alia include guidelines for notification by members of the board of directors and senior management if they have any material direct or indirect interest in any transaction entered into by the Company.

THE AUDIT COMMITTEE

The Company's audit committee is governed by the Norwegian Public Limited Liability Companies Act and a separate instruction adopted by the board of directors.

The members of the audit committee are appointed by and among the members of the board of directors. A majority of the members shall be independent of the Company's senior management, and at least one member shall have qualifications within accounting or auditing. Board members who are also members of the senior management cannot be members of the audit committee.

The principal tasks of the audit committee are to:

  • prepare the board of directors' supervision of the Company's financial reporting process;
  • monitor the systems for internal control and risk management;
  • have continuous contact with the Company's auditor regarding the audit of the annual accounts; and
  • review and monitor the independence of the Company's auditor, including in particular the extent to which services other than auditing provided by the auditor or the audit firm represent a threat to the independence of the auditor.

The audit committee currently consists of the following three members: Synne H. Røine (chairperson), Gwen Melincoff and Grannum R. Sant.

THE COMPENSATION COMMITTEE

The Company's compensation committee is governed by a separate instruction adopted by the board of directors. The members of the compensation committee are appointed by and among the members of the board of directors, and shall be independent of the Company's senior management.

The principal tasks of the compensation committee are to prepare:

  • the board of directors' declaration on determination of salaries and other remuneration for senior management in accordance with the Norwegian Public Limited Liability Companies Act section 6-16a; and
  • other matters relating to remuneration and other material employment issues in respect of the senior management.

The compensation committee currently consists of the following three members: Tom Pike (chairperson) and Jan H. Egberts.

Non-conformance with the recommendation: None

10. Risk management and internal control

The board of directors should on an ongoing basis assess the Company's risks. Each year, as a minimum, the board of directors has a thorough assessment of the significant parts of the Group's business and outlook, in order to identify risks and potential risks, and remedy any incident that have occurred. The board of directors may engage external expertise if necessary. The objective is to have the best possible basis for, and control of, the Company's situation at any given time.

In addition to the annual risk assessment, the management should present quarterly financial statements that will inform the board and shareholders on current business performance, including risk. These reports should be subject to review at the board meetings.

Significant risks include strategic risks, financial risks, liquidity risks and operational risks. The Company's significant risks are assessed on an ongoing basis and at least once a year by the board.

The Company's finance function is responsible for the preparation of the financial statements and to ensure that these are prepared and reported according to applicable laws and regulations and in accordance with IFRS. The audit committee performs reviews of the quarterly and annual financial statements with special focus on transaction types which includes judgments, estimates or issues with major impact on the financial statement. In additional to the quarterly and annual reporting, the board of directors receives monthly financial updates. Management controls are performed at a senior level in the Company.

Non-conformance with the recommendation: None

11. Remuneration of the Board of Directors

The remuneration of the board of directors shall be decided at the Company's general meeting, and should reflect the board of directors' responsibility, expertise, time commitment and the complexity of the Company's activities. The remuneration is not linked to the Company's performance.

The nomination committee shall give a recommendation as to the size of the remuneration to the board of directors. Pursuant to the instructions for the nomination committee, the recommendation should normally be published on the Company's website at least 21 days prior to the general meeting that will decide on the remuneration.

The Company has not granted share options to board members. Any remuneration in addition to normal fees to the members of the Board should be specifically identified in the annual report.

Members of the board of directors and/or companies with which they are associated should not take on specific assignments for the Company in addition to their appointment as a member of the board unless approved by the board of directors. The remuneration for such additional duties should be approved by the board of directors.

Non-conformance with the recommendation: None

12. Remuneration of the senior management

The board of directors shall in accordance with the Norwegian Public Limited Liability Companies Act prepare separate guidelines for the stipulation of salary and other remuneration to key management personnel. The guidelines shall include the main principles applied in determining the salary and other remuneration of the senior management, and shall ensure convergence of the financial interests of the senior management and the shareholders. It should be clear which aspects of the guidelines that are advisory and which, if any, that are binding thereby enabling the general meeting to vote separately on each of these aspects of the guidelines.

The board of directors aims to ensure that performancerelated remuneration of the senior management in the form of equity-based compensation, annual bonus programs or the like, if used, are linked to value creation for shareholders or the Company's earnings performance over time. Performancerelated remuneration should be subject to an absolute limit. Furthermore, the Company aims to ensure that such arrangements are based on quantifiable factors which the employee in question can influence.

The board of directors has established guidelines for remuneration of the key employees of the Company, and the guidelines will be presented to the annual general meeting in 2019. The remuneration guidelines are included in note 24 to the annual accounts. The compensation scheme for the Company´s senior management is based on a fixed salary, performance related bonus (capped based on fixed salary) and a restricted shares program. Performance-related remuneration is linked to value creation for the shareholders over time, and is based on quantifiable factors which the employees in question can influence.

Non-conformance with the recommendation: None

13. Information and communications

GENERAL

The Company has targeted investor relation activities with the aim to consistently provide the market with timely and accurate information. The Company's reporting of financial and other information is based on openness and takes into account requirements for equal treatment of all investors.

The board of directors has adopted a separate manual on disclosure of information, which sets forth the Company's disclosure obligations and procedures. The board of directors will seek to ensure that market participants receive correct, clear, relevant and up-to-date information in a timely manner, taking into account the requirement for equal treatment of all participants in the securities market.

The Company will each year publish a financial calendar, providing an overview of the dates for major events such as its ordinary general meeting and publication of interim reports.

INFORMATION TO SHAREHOLDERS

The Company shall have procedures for establishing discussions with important shareholders to enable the Board to develop a balanced understanding of the circumstances and focus of such shareholders. Such discussions shall be done in compliance with the provisions of applicable laws and regulations.

All information distributed to the Company's shareholders will be published on the Company's web site at the same time as it is sent to shareholders. The chairperson of the board and the chief executive officer are authorized to speak on behalf of the Company, and delegate such authority as is appropriate in relevant cases.

Non-conformance with the recommendation: None

14. Take-overs

In the event the Company becomes the subject of a take-over offer, the board of directors shall ensure that the Company's shareholders are treated equally and that the Company's activities are not unnecessarily interrupted. The board of directors shall also ensure that the shareholders have sufficient information and time to assess the offer.

The board of directors will not attempt to influence, hinder or complicate the submission of bids for the acquisition of the Company's operations or shares, or prevent the execution thereof. There are no defense mechanisms against take-over bids in the Articles of Association, nor have other measures been implemented to specifically hinder acquisitions of shares in the Company. The board of directors has not established written guiding principles for how it will act in the event of a take-over bid, as such situations are normally characterized by concrete and one-off situations which make a guideline challenging to prepare.

In the event a take-over was to occur, the board of directors will consider the relevant recommendations in the Corporate Governance Code and whether the concrete situation entails that the recommendations in the Corporate Governance Code can be complied with or not.

Non-conformance with the recommendation: The Company has not established separate principles for how to act in a take-over situation as described.

15. Auditor

The Company's external auditor is KPMG AS.

On an annual basis, the board of directors reviews with the auditor the Company's internal control procedures, including identified risk areas and proposals for improvement, as well as the main features of the plan for the audit of the Company.

Furthermore, the auditor participates in meetings of the board of directors that deal with the annual accounts and, at least once a year, carries out a review of the Company's procedures for internal control in collaboration with the audit committee. At least one board meeting with the auditor shall be held each year in which no member of the senior management is present.

The board of directors has established guidelines in respect of the use of the auditor by the senior management for services other than the audit.

The remuneration to the auditor will be approved by the ordinary general meeting. The board of directors will report to the general meeting details of fees for audit work and any fees for other specific assignments.

Non-conformance with the recommendation: None

Statement of Comprehensive Income

PARENT AMOUNTS IN NOK 1,000 GROUP
2018 2017 Notes 2018 2017
114,950 109,277 Sales revenues 1,2,3 173,237 149,181
8,273 1,730 Signing fees and milestone revenues 1,2,3 8,273 1,730
123,223 111,007 Total revenues 181,510 150,911
-16,837 -11,677 Cost of goods sold 5 -17,147 -12,011
106,386 99,330 Gross profit 164,363 138,900
2,337 668 Other income 0 0
-10,252 -11,293 Indirect manufacturing expenses 6 -10,252 -11,293
-19,145 -32,591 Research and development expenses 6 -19,145 -32,591
-41,595 -37,803 Marketing and sales expenses 6 -121,301 -96,430
-42,353 -45,957 Other operating expenses 6 -37,368 -43,789
-111,008 -126,976 Total other income and expenses recurring -188,066 -184,103
-4,621 -27,646 Operating profit/loss(-) before restructuring -23,703 -45,203
-10,683 0 Restructuring 9 -14,199 0
-15,304 -27,646 Operating profit/loss(-) -37,902 -45,203
19,421 5,949 Financial income 11 3,652 5,949
-2,464 -12,848 Financial expenses 11 -2,464 -2,326
16,957 -6,899 Net financial profit/loss(-) 1,188 3,622
1,653 -34,546 Profit/loss(-) before tax -36,714 -41,580
6 6,883 Tax expense 12 6 6,883
1,659 -27,663 Net profit/loss(-) -36,708 -34,697
0 0 Currency translation -308 -507
0 0 Total other comprehensive income items that may be reclassified to -308 -507
profit & loss
1,659 -27,663 Comprehensive income -37,016 -35,204
Earnings per share (Amounts in NOK): 13
Basic -1.70 -1.61
Diluted -1.70 -1.61

Statement of Financial Position

PARENT AMOUNTS IN NOK 1,000 GROUP
2018 2017 Notes 2018 2017
ASSETS
880 998 Machinery and equipment 14 2,141 1,268
22,502 33,315 Intangible assets 14 22,502 33,315
747 - Contract assets 3, 4 747 -
266,963 227,467 Loan to group company 25 - -
5,528 5,528 Shares in subsidiary 15 - -
52,377 52,903 Deferred tax asset 12 52,377 52,903
348,998 320,211 Total non-current assets 77,767 87,486
17,848 18,996 Inventories 16 18,582 19,552
11,224 8,427 Accounts receivable 17, 19 20,371 14,573
5,399 11,030 Other receivables 17, 19 7,643 12,119
105,960 128,991 Cash and short term deposits 18, 20 106,833 129,368
140,430 167,444 Total current assets 153,429 175,613
489,428 487,655 Total assets 231,196 263,099
EQUITY AND LIABILITIES
10,890 10,779 Share capital 21 10,890 10,779
63,656 57,740 Other paid-in capital 63,656 57,740
369,612 378,576 Retained earnings 101,797 149,561
444,157 447,095 Total equity 176,342 218,080
1,849 4,279 Pension liabilities 8 2,401 4,752
1,849 4,279 Total non-current liabilities 2,401 4,752
8,982 14,338 Accounts payable 17, 23 10,182 15,081
4,343 3,694 Employee withholding taxes and social security tax 4,343 3,694
7,064 - Contract liabilities 3, 4 7,064 -
23,033 18,250 Other current liabilities 17, 23 30,864 21,492
43,422 36,281 Total current liabilities 52,453 40,267
45,271 40,560 Total liabilities 54,854 45,019
489,428 487,655 Total equity and liabilities 231,196 263,099

Oslo, 16 April 2019 The Board of Directors of Photocure ASA

Jan H. Egberts Chairperson

Johanna Holldack Director

Gwen Melincoff Director

Tom Pike Director Synne H. Røine Director

Grannum R. Sant Director

Daniel Schneider President and CEO

Statement of Changes in Equity

PARENT
(Amounts in NOK 1,000)
Issued capital Treasury
shares
Other paid
in equity
Translation
reserve
Retained
earnings
Total equity
Equity as of 31 December 2016 10,779 -31 54,804 0 406,240 471,792
Comprehensive income:
Net profit for the year -27,663 -27,663
Other comprehensive income that may
be reclassified to p&l
- - 0
Total comprehensive income 0 0 0 0 -27,663 -27,663
Transaction with owners:
Capital increase 0
Sale own shares 0
Employees' options 2,967 2,967
Total transaction with owners 0 0 2,967 0 0 2,967
Equity as of 31 December 2017 10,779 -31 57,771 0 378,577 447,095
Adjustments initial applications of IFRS 15 & IFRS 9 -10,626 -10,626
Adjusted equity beginning of period 10,779 -31 57,771 0 367,952 436,470
Comprehensive income:
Net profit for the year 1,659 1,659
Other comprehensive income that may
be reclassified to p&l
- - 0
Total comprehensive income 0 0 0 0 1,659 1,659
Transaction with owners:
Capital increase 111 6,229 6,339
Buy back own shares -377 -377
Employees' options 64 64
Total transaction with owners 111 -377 6,293 0 0 6,026
Equity as of 31 December 2018 10,890 -408 64,063 0 369,611 444,157
GROUP
(Amounts in NOK 1,000)
Issued capital Treasury
shares
Other paid
in equity
Translation
reserve
Retained
earnings
Total equity
Equity as of 31 December 2016 10,779 -31 54,804 920 185,471 251,943
Comprehensive income:
Net profit for the year -34,697 -34,697
Other comprehensive income
that may be reclassified to p&l
- -507 - -507
Total comprehensive income 0 0 0 -507 -34,697 -35,204
Transaction with owners:
Capital increase 0
Sale own shares 0
Employees' options 2,967 -1,626 1,341
Total transaction with owners 0 0 2,967 0 -1,626 1,341
Equity as of 31 December 2017 10,779 -31 57,771 413 149,148 218,080
Adjustments initial applications of IFRS 15 & IFRS 9 -10,747 -10,747
Adjusted equity beginning of period 10,779 -31 57,771 413 138,400 207,332
Comprehensive income:
Net profit for the year -36,708 -36,708
Other comprehensive income
that may be reclassified to p&l - -308 - -308
Total comprehensive income 0 0 0 -308 -36,708 -37,017
Transaction with owners:
Capital increase 111 6,229 6,339
Buy back own shares -377 -377
Employees' options 64 64
Total transaction with owners
Equity as of 31 December 2018
111
10,890
-377
-408
6,293
64,064
0
105
0
101,692
6,026
176,342

Statement of Cash Flows

PARENT AMOUNTS IN NOK 1,000 GROUP
2018 2017 Notes 2018 2017
1,653 -34,546 Profit/loss(-) before tax -36,714 -41,580
12,968 12,000 Ordinary depreciation & amortisation 14 13,211 12,108
-3,378 - Deferred income milestones 3, 4 -3,378 -
63 1,114 Share-based payments expense 7 63 1,341
624 650 Pension costs 8 785 891
-1,125 -2,310 Interest income -1,125 -2,310
-15,770 10,522 Unrealized currency (gain)/loss loan subsidiary 11 - -
-43 -51 Unrealized currency (gain)/loss other -43 -51
52 - Other items -188 -388
Changes in
1,149 -1,540 - inventories 970 -1,598
2,834 -16 - trade and other receivables -1,515 -1,619
-5,355 4,556 - trade and other payables -4,899 5,172
5,433 3,897 - provisons and other accruals 10,021 4,441
-1,846 - Changes in contract liabilities 3, 4 -1,846 -
533 - Taxes refunded 12 533 -
-2,208 -5,724 Net cash flow from operating activities -24,124 -23,593
1,125 2,310 Interest received 1,125 2,310
-23,725 -16,393 Loan to subsidiary 25 - -
-398 -888 Investments in machinery and equipment 14 -1,630 -1,050
-559 -17,538 Development expenditures 14 -559 -17,538
-23,557 -32,509 Net cash flow from investing activities -1,064 -16,278
-3,228 - Reclassification and payment of non-current liability 9 -3,310 -
6,339 - Proceeds from exercise of share options 7 6,339 -
-377 - Buy back (-) / Sale own shares -377 -
2,734 0 Net cash flow from financing activities 2,652 0
-23,030 -38,233 Net change in cash during the year -22,535 -39,871
128,991 167,223 Cash and cash equivalents as of 01 January 129,368 169,239
105,960 128,991 Cash and cash equivalents as of 31 December 106,833 129,368

Accounting principles 2018

I. General information

The annual accounts for 2018 for Photocure ASA (the Parent Company) and its subsidiary Photocure Inc (together the Group or Photocure) were approved for publication by the Board of Directors on 16 April 2019.

Photocure ASA is a public limited company domiciled in Norway. The business of the Group is associated with research, development, production, distribution, marketing and sales of pharmaceutical products. The Company's shares are listed on the Oslo Stock Exchange. The Parent Company's registered office is Hoffsveien 4, NO-0275 Oslo, Norway.

II. Basis for preparation of the annual accounts

The annual accounts for the Group and the Parent Company have been prepared on the basis of historical cost, with the exception of in money market funds that is valued at fair value.

The Group and the Parent Company's annual accounts are prepared in accordance with International Financial Reporting Standards (IFRS) as specified by the International Accounting Standards Board and implemented by the EU as per 31 December 2018.

Photocure ASA has NOK (Norwegian kroner) as its functional currency and presentation currency. In the absence of any statement to the contrary, all financial information are reported in whole thousands. As a result of rounding adjustments, the figures in the financial statements may not add up to the totals. Photocure performs the sales and distribution of Hexvix in the Nordic market and in the US through its wholly owned subsidiary Photocure Inc under the trade name Cysview. Photocure Inc has USD (US dollars) as its functional currency.

III. Changes in significant accounting policies

IFRS 15

Revenue from contract with customers establishes a comprehensive framework for determining whether, how much and when revenue is recognized. The standard replaces IAS 18 Revenue and related interpretations. IFRS 15 is effective for annual reporting periods beginning on or after 1 January 2018. The new standard contains a new set of principles on when and how to recognize and measure revenue as well as new requirements related to presentation. The core principle in that framework is that revenue should be recognized dependent on the transfer of promised goods or services to the customer for an amount that reflects the consideration which should be received in exchange for those goods or services. The objective is to provide a five-step approach to revenue recognition that includes identifying contracts with customers, identifying performance obligations, determining transaction prices, allocating transaction prices to performance obligations, and recognizing revenue when or as performance obligations are satisfied.

A. The adoption of IFRS 15 has an impact on Photocure's timing of recognition of sale of goods. The timing effect of recognition of sales of goods is calculated to be approximately NOK 6.4 million in reduction of equity as of January 1, 2018. The timing effect as of 31 December 2018 is NOK 4.5 million.

B. Under IFRS 15 up-front fees not related to a separate performance obligation will be recognized over the term of the contract upon the delivery of goods. For current contracts the contract term is estimated to be equal to the expiry date of the patents in the relevant market areas. This result in revenue being deferred compared to revenue recognition under the previous standard. There is currently only one material open contract, entered into in 2011 where patents will expire in 2019, Deferred contract revenue as of January 1, 2018 is calculated to NOK 5.9 million while related contract costs have remaining amortization of NOK 1.7 million giving net adjustment of equity NOK 4.2 million. As of 31 December 2018 remaining deferred contract revenue is NOK 2.5 million while related contract costs have remaining amortization of NOK 0.7 million. Total contract liabilities as of 31 December is NOK 7.0 million.

IFRS 9

IFRS 9 contains a new classification and measurement approach, impairment and hedge accounting rules for financial assets and liabilities. IFRS 9 is effective for annual periods beginning on or after 1 January 2018. Photocure has analyzed the impact of implementing IFRS 9 Financial Instruments from 1 January

  1. Based on the contracts, financial assets and liabilities currently held by the Group, the impact on Photocure's financial statements are evaluated to be insignificant. Financial assets measured at amortised cost under IAS 39 are measured at amortised cost also under IFRS 9. The impact 1 January 2018 of changing from the incurred loss model under IAS 39 to the expected loss model under IFRS 9 on trade receivables, amounts to NOK 0.2 million. As of 31 December 2018 the expected loss in the Group is NOK 0.3 million.

IV. Disclosures regarding new standards not yet effective

IFRS 16

IFRS 16 introduces a single, on-balance sheet accounting model for lessees. The standard is effective for annual period beginning on or after 1 January 2019. The adoption of IFRS is not expected to have a significant impact on Photocure's statement of financial position as future lease payments under existing lease contracts are limited, ref. note 14. The preliminary calculation of the expected leasing liabilities as per 1 January 2019 related to office lease contracts amounts to approximately NOK 10.0 million.

There are no other IFRSs or IFRIC interpretations that are not yet effective that would be expected to have a material impact on the Group. The new and amended standards and interpretations from IFRS that were adopted by the EU with effect from 2018 did not have any significant impact on the reporting in 2018.

Estimated
Estimated
adjustments
adjustments
Estimated
adjustments
Estimated
adjustments
As reported at due to due to due to opening
Estimated impact of adaption of IFRS 9 and IRFS 15 31 December adoption of adoption of adoption of balance at 1
(Amounts in NOK 1000) 2017 IFRS 9 IFRS 15.A IFRS 15.B January 2018
Retained earnings 149,561 -209 -6,402 -4,168 138,782
Total 149,561 -209 -6,402 -4,168 138,782

V. Use of judgements and estimates

In preparation of these consolidated financial statements, management has made judgments, estimates and assumptions that affect the application of the Group's accounting policies and the reported amounts of assets, liabilities, income and expenses. Actual results may differ from these estimates.

Estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to estimates are recognized prospectively. Information about judgements made in applying accounting policies that have the most significant effects on the amounts recognized, and information about assumptions and estimation uncertainties that have significant risk of resulting in a material adjustment in the financial statements as of 31 December 2018, are included in the following notes:

  • Note 3 Revenue: the assumptions in implementation of IFRS 15 and various considerations in the five-step model.
  • Note 12 Recognition of deferred tax asset: available future taxable profit against which tax losses carried forward can be used.
  • Note 14 Development expenditures: key assumptions underlying the capitalized development costs.
  • Note 25 Long term loan subsidiary: impairment and key assumptions underlying the balance sheet value in parent company.

VI. Summary of important guidelines for accounting for the Group

A. CLASSIFICATION

Assets/liabilities are classified as current assets/current liabilities when they meet one of the following criteria:

  • They are expected to be realized in the Group's ordinary operating cycle or are kept for sale or consumption;
  • They are expected to be realized within 12 months of the balance sheet date; or
  • They are in the form of cash or a cash equivalent.
  • All other assets/liabilities are classified as fixed assets/long-term liabilities

B. CURRENCY

Monetary items in foreign currencies are converted at closing rate of exchange. In the absence of any statement to the contrary, realized and unrealized exchange rate gains and losses are included in financial income or expenses. Transactions in foreign currencies are recorded at the exchange rate on the

date of transaction. Assets and liabilities in foreign currencies are translated into NOK at the exchange rate applicable on the balance sheet date.

Income and expenses in foreign subsidiaries are translated into NOK at the average exchange rate for the financial statement period. The assets and liabilities of the foreign subsidiaries are translated to NOK at exchange rates at the reporting date.

C. PROPERTY, PLANT AND EQUIPMENT

Tangible fixed assets are recognized at cost less deductions for accumulated depreciation and accumulated impairment losses. Tangible fixed assets are depreciated over the expected useful life of the assets taking any residual value into consideration. Costs incurred for major replacements and upgrades of tangible fixed assets are added to cost if it is probable that the costs will generate future economic benefits for the Group and if the costs can be reliably measured. Ordinary maintenance is expensed as incurred.

Tangible fixed assets are depreciated on a straight-line basis over the estimated useful life of the asset as follows:

- Production and test equipment 5 years
- Furniture and office equipment 3–5 years

D. INTANGIBLE ASSETS

Capitalized development expenditures are recognized at cost less accumulated amortization and accumulated impairment losses. The expenditure capitalized includes the costs of services and materials rendered by external suppliers and own pharmaceutical ingredients and devices directly attributable to the development of the product. Internal personal and overhead costs are not capitalized.

Intangible development expenditures are amortized on a straight-line basis in the profit and loss over the remaining patent period for the approved product and indication as follows: - Product development 4 - 10 years

E. IMPAIRMENT

Financial assets and tangible & intangible fixed assets that are recognized in the balance sheet, are tested for impairment if there are indications of a permanent loss in value. If the book value of an asset is higher than the recoverable value of the asset, the loss in value is recognized in profit and loss. The recoverable value is the highest of net sales value and the value in use of the asset. Tangible fixed assets are grouped and measured at the lowest level for determining loss in value.

Previous impairment losses are reversed to the extent that the assets carrying amount does not exceed the carrying amount that would have been determined, net of depreciation and amortization, if no impairment loss had been recognized or taken place.

F. RESEARCH AND DEVELOPMENT COSTS

Research costs are expensed as incurred. Development costs are recognized in the balance sheet as intangible assets only if there is an identifiable asset that is expected to generate future financial benefits, and when the costs of such an asset can be reliably measured. Development costs are recognized in the balance sheet as intangible assets if all the following criteria are fulfilled:

  • It is technically possible to complete the asset so that it can be available for use or for sale;
  • The purpose is to complete the asset for use or for sale;
  • The Group is able to use or sell the asset;
  • The asset will provide future financial benefits, a market exists for the asset or the output of the asset or that the asset is useful if it is to be used internally.
  • Sufficient technical, financial or other resources are available to carry out the development and to use or sell it, and
  • The opportunity exists to reliably measure costs associated with the intangible asset.

When all the criteria listed above have been met, costs related to development are to be recognized in the balance sheet. Development costs that have been expensed in previous accounting periods cannot be recognized in the balance sheet at a later date. Cost-sharing of research and development expenses with license partners is booked as a reduction in costs.

The work of the regulatory function and services provided are related to both market expansion and product development. Photocure classifies for this reason the regulatory function into the following two categories:

  • Regulatory work and services related to new products or product development based on new clinical trials up to and including phase 3, are classified as R&D costs
  • Regulatory work and services for new markets based on existing clinical data are classified as marketing costs

G. INVESTMENT IN SUBSIDIARY COMPANIES

Shares and investments with the aim of long-term ownership are booked in the balance sheet as long-term investments and are valued at the lower of cost and fair value. Write-downs for permanent declines in value are made on the basis of individual evaluations. Any realized and unrealized profits/losses and any

write-downs related to these investments will be booked in the income statement as financial items.

H. INVENTORIES

Raw materials are valued at the lower of cost and net sales value in accordance with the first-in, first-out principle (FIFO). Semi-finished and finished goods are valued at production cost including a mark-up for their share of the indirect production costs based on the FIFO principle.

I. FINANCIAL ASSETS AND LIABILITIES

Recognition and measurement

Trade receivables are initially recognised when they are originated. All other financial assets and financial liabilities are initially recognised when the Group becomes a party to the contractual provisions of the instrument. A trade receivable without a significant financing component is initially measured at the transaction price. All other financial assets are initially measured at fair value plus, for an item not at fair value through, transaction costs that are directly attributable.

A financial asset is subsequently measured at amortised cost if it meets both of the following criteria and is not designated as at Fair Value Through Profit and Loss (FVTPL):

  • it is held within a business model whose objective is to hold assets to collect contractual cash flows; and
  • its contractual terms give rise on specified dates to cash flows that are solely payments of principal and interest on the principal amount outstanding.

Trade receivables, loan to group companies, and other receivables meet both of these criteria and are measured at amortised cost using effective interest rate method. A debt investment is subsequently measured at Fair Value through Other Comprehensive Income (FVOCI) if it meets both of the following criteria and is not designated as at FVTPL:

  • it is held within a business model whose objective is achieved by both collecting contractual cash flows and selling financial assets; and
  • its contractual terms give rise on specified dates to cash flows that are solely payments of principal and interest on the principal amount outstanding.

Photocure has no financial asset that meet both of these criteria. All financial assets not classified as measured at amortised cost or FVOCI as described above are subsequently measured at FVTPL. Photocure's investments in money market funds are measured at FVTPL.

Interest bearing liabilities are recognised at fair value at the time of recognition. In subsequent periods, interest-bearing liabilities are booked at amortised cost according to the effective interest rate method.

Financial income consists of interest income on bank balances and money market fund as well as exchange rate gains from currency items. Financial expense consists of interest expense on borrowing and exchange rate losses from currency items.

Impairment

The Group recognises loss allowances for expected credit losses (ECLs) on financial assets measured at amortised cost. The Group measures loss allowances at an amount equal to lifetime ECLs, except for the following, which are measured at 12-month ECLs:

  • debt securities that are determined to have low credit risk at the reporting date; and
  • other debt securities and bank balances for which credit risk (i.e. the risk of default occurring over the expected life of the financial instrument) has not increased significantly since initial recognition.

The Group assumes that the credit risk on a financial asset has increased significantly if it is more than 30 days past due. Lifetime ECLs are the ECLs that result from all possible default events over the expected life of a financial instrument. 12-month ECLs are the portion of ECLs that result from default events that are possible within the 12 months after the reporting date (or a shorter period if the expected life of the instrument is less than 12 months). Loss allowances for trade receivables and contract assets are always measured at an amount equal to lifetime ECLs. The Group uses an allowance matrix based on historical losses adjusted for forward-looking information. For other financial assets measured at amortised cost the ECLs are probability-weighted estimates of credit losses discounted at the effective interest rate of the financial asset.

J. REVENUE RECOGNITION

The Group has initially applied IFRS 15 from 1 January 2018. Information about the Group's accounting policy relating to contracts with customers is provided in Note 3. The effect of initially applying IFRS 15 is described in Note 4.

Revenues for the sale of products are recorded on the date of delivery, when both control and risk essentially have been transferred to the buyer.

License agreements that give the right to a guaranteed minimum royalty are booked as revenue at the time the prerequisite is fulfilled. Royalty revenue is booked as Sales revenue in line with the licensee's sale of licensed products.

K. GOVERNMENT GRANTS

Government grants are booked at the same time as the income that it shall generate or the cost that it shall reduce. Grants received for product development or manufacture are first booked as reduction of costs when the conditions for the grant in question have been met and the applications are granted. Grants received for product development that are capitalized, are reported as reduction of gross expenditures and the net expenditures are regarded as the intangible assets.

L. LICENSE COSTS

The Group has entered into agreements with external parties concerning access to technology in the form of license agreements and agreements that allow the use of patented technology. Royalty-based payments on products are booked as an expense in line with the sale of the licensed products, and booked in the income statement as "Cost of goods sold". License payments associated with signing fees and milestone payments concerning regulatory approval and product launches are booked as an expense when they occur and are reported as "Other operating expenses" in the income statement.

M. PENSIONS

Photocure ASA has an agreement with a life assurance company concerning contribution-based pensions for Photocure's employees. Pension contributions are paid into the employee's contribution account with the life assurance company. The Company's payment of contributions is expensed in the period it is accrued. Any prepayments made to the contribution fund are recognized in the balance sheet.

Salary to senior management employees in Photocure ASA above 12 x G is subject to agreements concerning operational coverage of pensions for salary above this level in the form of contribution-based pensions. The calculated contribution constitutes 16% of the employee's salary above 12 x G.

Employees residing in the United States participate in a 401(k), a tax-qualified, defined-contribution pension account defined in subsection 401(k) of the Internal Revenue Code. In addition, Photocure Inc has established an additional unfunded pension coverage for senior managers accruing annually an amount equal to 4% of salary and earned bonus.

The calculated pension obligation pursuant to these schemes are interest-bearing.

N. SHARE REMURATION AND OTHER BENEFITS RELATED TO SHARE BASED REMUNERATION

Employees may receive an award related to annual base salary at the time of granting with which the employees are obliged to buy shares at fair value in the Company. The award is offered to the employees according to the Board's discretion.

The plan is a performance base remuneration element reflecting the underlying long term value creation of the company. The participant receiving the grant is required to invest the net amount after tax into shares in the Company ("Restricted Stocks"), that will be subject to a three years' lock up period. The Company will, on behalf of the employee, seek to facilitate the share purchase with the use of treasury shares or share capital increases. The board of directors has decided further terms and conditions for the Restricted Stock plan including lock-up and termination of employment.

Employees have been offered share options to 2017 to the Company's shares as an element of the Group's employee incentive policy. If the Group has a sufficient amount of own shares, the Group may allot own shares instead of issuing new shares when share options are exercised. All share options granted 2014 and later, are offered at strike prices that reflect the market price +10% of the shares at the time of allotment of the rights.

The fair value is expensed over the share options vesting period and the Company's equity is increased correspondingly. The fair value of share options is calculated according to the Black-Scholes model. Each program is calculated separately with the actual strike price and duration of the program. The share options cease to be valid immediately on the employee's resignation from the Company.

Employer's social security contributions on outstanding share options are accrued as personnel costs over the vesting period based on the intrinsic value of the rights.

The fair value of the amount payable to employees in respect of restricted shares, which are settled in cash, is recognized as an expense with a corresponding increase in liabilities, over the period during which the employees become unconditionally entitled to payment. The liability is remeasured at each reporting date and at settlement date. Any changes in the liability are recognized in profit or loss.

O. TAX

The tax expense in the income statement includes both the income tax payable for the period and changes in deferred tax. Deferred tax in Norway is calculated at rate of 22% and in the USA at an effective rate of 30% on the basis of the temporary differences that exist between the tax value of the assets and liabilities, and their book value.

Liabilities for deferred tax are included for all temporary differences that increase tax, except when the asset in connection with deferred tax arises as a result of the first-time inclusion of an asset or liability in a transaction that is not in a business combination and affects neither the accounting nor the taxable profit or loss at the time of the transaction.

Assets in connection with deferred tax are included for all taxreducing temporary differences, carry forward of tax deductions and tax losses in the extent that there is objective proof that there will be sufficient taxable profits against which to offset taxreducing temporary differences, and carry forward of unused tax deductions and tax losses.

In the US the tax years 2017 and prior, businesses were able to offset current taxable income by claiming net operating losses (NOLs), generally eligible for a two-year carryback and 20-year carryforward. Starting in tax year 2018, NOLs cannot be carried back, but can be indefinitely carried forward. In addition, NOLs for tax years beginning in 2018 will be subject to an 80-percent limitation. The 80 percent limitation on NOL deductions applies to losses generated in tax years beginning after December 31, 2017. NOLs generated in 2017 and earlier would retain their 20-year life and be available to offset 100 percent of taxable income, subject to certain limitations. Companies will have to track their NOLs in different buckets based on date (pre and post December 31, 2017).

The book value of assets in connection with deferred tax is reviewed on every balance sheet date and is reduced to the degree that there is no longer any objective proof that there will be sufficient taxable profits to utilize all or parts of assets in connection with deferred tax. Non-recognized assets in connection with deferred tax are reviewed every balance sheet date and are included to the degree that it is probable that future taxable profits will allow the recovery of assets in connection with deferred tax. Each taxable entity in the Group are treated separately.

P. EARNINGS PER SHARE

Earnings per share is calculated on the basis of the profits for the period after tax but before "Other comprehensive income", divided by a weighted average number of outstanding shares in the period and adjusted for the treasury shares.

The diluted earnings per share are calculated by adjusting the denominator for amounts outstanding on option programs. Anti-dilution effects are not taken into consideration.

Q. PROVISIONS

Provisions are booked when the Group has a liability associated with an event, when it is probable that the liability will have to be settled and when the liability can be measured or estimated.

When the Group expects that all or parts of the liability can be charged on to another party, this recharge will be recorded as an account receivable if there is virtual certain that the other party will pay. The cost associated with a provision will be recorded net in the income statement after deduction for the recharge.

R. CONTINGENT LIABILITIES AND ASSETS

Contingent liabilities are defined as:

  • Possible liabilities as a result of earlier events where their existence depends on future events;
  • Liabilities that are not included because it is not probable that they will lead to an outflow of resources from the Group;
  • Liabilities that cannot be measured with sufficient reliability.

Contingent liabilities are not included in the annual accounts. Notes on significant contingent liabilities are provided, with the exception of contingent liabilities with little probability of occurring.

Contingent assets are not included in the annual accounts, but are reported in cases in which there is a certain likelihood of their resulting in a benefit to the Group.

S. EVENTS AFTER THE BALANCE SHEET DATE

New information regarding the Group's financial position on the balance sheet date has been taken into account in the annual accounts. Events after the balance sheet date that do not affect the Group's financial position on the balance sheet date, but which will affect the Group's financial position in the future, are reported if they are significant.

T. CASH FLOW STATEMENT

The cash flow statement has been prepared in accordance with the indirect method. Cash and cash equivalents consists of cash, bank deposits and other current investments like money market funds.

U. EQUITY

Amounts that are distributed to or contributed by shareholders are included directly in the equity. The Group's equity is increased in direct relation to the cost of share-based remuneration for employees.

  1. The nominal value of treasury shares is presented in the balance sheet as a negative equity element. The net purchase price is entered as a reduction of other paid-in equity. Profits or losses on transactions in treasury shares are not included in the income statement.

  2. Transaction charges in connection with equity transactions are included directly in equity after deduction for tax. Only transaction charges that are directly attributable to the equity transaction are included directly in equity.

V. LEASE AGREEMENTS

The decision as to whether an agreement is, or contains, a lease is based on underlying conditions in the transaction and requires an assessment of whether fulfillment of the agreement is dependent on the use of a specific asset and whether this entails a right to use the asset.

The rental sum in operational lease contracts is charged against income on a straight-line basis over the period of the lease. The lease sum is separated from payment for other elements in the agreement, and the amounts are recorded separately.

W. SEGMENT REPORTING

Segments are reported similarly as the internal reporting to the Group's senior decision makers. Senior decision makers are defined as the Group's management group.

Notes to the Financial Statements for 2018

OWN SALES AND LICENSING OF HEXVIX AND CYSVIEW

In 2011 Photocure entered into an agreement with Ipsen Pharma SAS (Ipsen) for marketing, sales and distribution of Hexvix in most of Europe and rest of the world excluding the US, Nordic region and certain other countries.

In August 2015 Photocure appointed BioSyent Pharma Inc. as our exclusive distributor for the commercialization of Cysview in Canada. BioSyent Pharma will fund all costs related to the launch and commercialization of Cysview, which was approved by Health Canada in January 2015. In May 2015 Photocure appointed Juno Pharmaceuticals as our exclusive distributor for the registration and commercialization of Hexvix in Australia and New Zealand.

In 2016 Hexvix was approved by Australian health authorities and by New Zealand health authorities in 2017.

OPERATING SEGMENTS

The operating segments follow the current business model for Photocure which consists of two segments: Commercial Franchise and Development Portfolio. The Commercial segment include the Hexvix/Cysview products and is broken down into own sales and partner sales by market segments and other sales. The Development segment is split by development of commercial products and pipeline products. Sales revenue from own sales in Commercial segment consists of Hexvix sales to pharmaceutical wholesalers in Nordic markets and sales of Cysview to hospitals in the US. Sales through partners comprise mainly sales of Hexvix to Ipsen in Europe outside the Nordic region and royalties from sales by Ipsen to end users. Milestone revenue within partner subsegment include deferred milestone payments in accordance with implementation of IFRS 15.

In April 2017, Photocure and Bellus Medical signed an asset purchase and licensing agreement for Photocure's cosmetic dermatology product Allumera. Under the terms of this agreement, Photocure received USD 200,000 at signing. Photocure has in 2018 received two more payments of each USD 300,000. Other Sales in the Commercial segment consists of the resale of the HIVEC product from Combat and royalties from Bellus.

Operating costs are charged directly to the respective segment involved if directly related. Indirect manufacturing costs are allocated based on sales within the commercial segment and other indirect costs are allocated based on time and resources utilized within the different subsegments. Government research grants are offset against operating expenses.

1 Jan - 31 December 2018 Commercial Franchise Development Portfolio
Amounts in NOK 1,000 Hex/Cys
Own sales
Hex/Cys
Partner
Other
Sales
Total
Sales
Hex/Cys
Develop.
Pipeline Total
R&D
Grand
Total
Sales Revenues 110,725 62,209 303 173,237 - - - 173,237
Milestone revenues - 3,378 4,895 8,273 - - - 8,273
Cost of goods sold -6,562 -10,514 -71 -17,147 - - - -17,147
Gross profit 104,163 55,073 5,127 164,363 - - - 164,363
Gross profit of sales % 94 % 83 % 77 % 90 % 90 %
R&D - - - - -2,363 -6,962 -9,325 -9,325
Sales & marketing -113,961 -6,258 - -120,219 - -994 -994 -121,213
Other & allocations -18,123 -17,630 - -35,753 -1,357 -7,206 -8,563 -44,317
Operating expenses -132,084 -23,888 - -155,972 -3,721 -15,162 -18,883 -174,855
EBITDA before restructuring -27,921 31,185 5,127 8,391 -3,721 -15,162 -18,883 -10,492
Depreciation and Amortization -2,921 -10,290 -13,211

EBIT before restructuring 5,470 -29,173 -23,703

1

2

1 Jan - 31 December 2017 Commercial Franchise Development Portfolio
Amounts in NOK 1,000 Hex/Cys
Own sales
Hex/Cys
Partner
Other
Sales
Total
Sales
Hex/Cys
Develop.
Pipeline Total
R&D
Grand
Total
Sales Revenues 85,720 63,295 166 149,181 - - - 149,181
Milestone revenues - - 1,730 1,730 - - - 1,730
Cost of goods sold -3,403 -8,607 - -12,011 - - - -12,011
Gross profit 82,316 54,688 1,895 138,900 - - - 138,900
Gross profit of sales % 96 % 86 % 100 % 92 % 92 %
R&D - - - - -3,905 -18,991 -22,896 -22,896
Sales & marketing -84,022 -8,320 - -92,342 - -4,012 -4,012 -96,355
Other & allocations -14,195 -21,208 -765 -36,168 -4,028 -12,548 -16,576 -52,744
Operating expenses -98,218 -29,527 -765 -128,510 -7,933 -35,551 -43,485 -171,995
EBITDA before restructuring -15,901 25,160 1,130 10,390 -7,933 -35,551 -43,485 -33,095
Depreciation and Amortization -1,612 -10,496 -12,108
EBIT before restructuring 8,778 -53,981 -45,203

The definition of EBITDA is "Earnings Before Interest, Tax, Depreciation and Amortization".

REVENUE

The Group has initially adopted IFRS 15 'Revenue from Contracts with Customers' from 1 January 2018. The effect of initially applying IFRS 15 on the Group's revenue from contracts with customers is described in Note 4.

Performance obligations

For the sales of products Photocure satisfy the contractual performance obligation upon delivery of products according to the delivery terms agreed. Invoices are issued at that point in time and the payment term is usually within 30 days. No discounts are provided to the customers and no return of products are accepted within the expiry of the products.

Revenue were recognized under IAS 18 prior to 1 January 2018 at the point in time the goods were delivered to customers and at wich the customer accepted the goods and the related risks and rewards of ownership transferred.

Revenue is recognized under IFRS 15 from 1 January 2018 at the point in time the products are delivered and have been accepted by customers at agreed terms. For delivery to license partner the timing of revenue recognition is deferred to the point in time the products are delivered to their customers.

Contract balances

The timing effect of recognition of sales of products under IFRS 15 is calculated to be NOK 6.4 million 1 January, 2018 and disclosed as contract liability. The timing effect as of 31 December 2018 is NOK 4.5 million giving increased sales revenue of NOK 1.846 thousands and a corresponding decrease of contract liabilities, see Note 4 Adjustments.

Under IFRS 15 up-front fees not related to a separate performance obligation are recognized over the term of the contract upon the delivery of goods. For current contracts the contract term is estimated to be equal to the expiry date of the patents in the relevant market areas. This result in revenue being deferred compared to revenue recognition under the previous standard. There is currently only one material open contract, entered into in 2011 where patents will expire in 2019. Deferred contract revenue as of 1 January, 2018 is calculated to NOK 5.9 million and disclosed as part of the contract liability balance of NOK 12.3 million. As of 31 December 2018 remaining deferred contract revenue is NOK 2.5 million resulting in increased Signing fee and milestones revenues of NOK 3.378 thousands and a corresonding decrease in contract liability, see Note 4 Adjustments. Total contract liabilities as of 31 December 2018 is NOK 7.1 million.

Assets recognised from the costs obtained to fulfil the material open contract as of 1 January 2018 is calculated to remaining balance of NOK 1.7 million and disclosed as contract cost. The amortization of the contract assets is allocated on a straight line basis to the remaining patent protection period from contract entered in 2011 to expry of patent in 2019. This result in amortization of contract assets of NOK 1 million in 2018 and remaining contact assets of NOK 0.747 million as f 31 December 2018.

In the segment table the Hexvix & Cysview revenue from partners correspond to the revenue from contract with customers. The milestone revenue from partners in 2018 represent the deferred revenue according to IFRS 15.

Sales Revenues of Hexvix & Cysview in own markets and Other sales of other products in the segment table are regular sales orders to pharmaceutical wholesalers in the Nordic markets and sales of Cysview to hospitals in the US not based on signed contracts.

Sales revenue of Hexvix & Cysview to its own customers are recognized at a point in time when ownership of the products are transferred.

The milestone revenue under Other sales in 2017 and 2018 from Bellus Medical is not based on contractual performance obligations by Photocure but agreed down payment terms for the sale of the Allumera product rights in USA.

The geographical revenue information is based on the location of the end customers. The signing fees and milestone revenue are not included in the following table.

Amounts in NOK 1,000 Group sales revenues
Geographical information 2018 2017
Nordic countries 47,221 43,278
United States 63,807 42,607
Own sales 111,028 85,885
Partner countries Europe 61,614 63,296
Partner countries rest of world 595 0
173,237 149,181
Timing of revenue recognition 2018 2017
Products transferred at a point in time 172,934 149,015
Products transferred over time - -
Revenue from contract with customers 172,934 149,015
Other revenue 303 166
173,237 149,181

CHANGES IN SIGNIFICANT ACCOUNTING POLICIES

The Group has adopted IFRS 15 using the cumulative effect method and accordingly, the information presented for 2017 has not been restated. The following table summarizes the impact of transition to IFRS 15 and IFRS 9 on retained earnings at 1 January 2018 and 31 December 2018. Further information regarding the contract assets and contract liabilities under the IFRS 15 are disclosed in Note 3.

Amounts in NOK 1,000
Statement of financial position 01.01.2018 31.12.2018
As reported Adjustments Without
adjustments
As reported Adjustments Without
adjustments
Intangible assets 33,315 33,315 22,502 22,502
Contract assets 1,744 -1,744 - 747 -747 -
Other non-currrent assets 54,171 54,171 54,518 54,518
Accounts receivable 14,371 202 14,573 20,371 288 20,660
Other currrent assets 161,040 161,040 133,058 133,058
Total assets 264,641 -1,542 263,099 231,196 -459 230,737
Shareholders' equity 207,334 10,746 218,080 176,342 6,605 182,947
Long-term liabilities 4,752 4,752 2,401 2,401
Contract liabilities 12,288 -12,288 - 7,064 -7,064 -0
Other current liabilities 40,267 40,267 45,389 45,389
Total equity and liabilities 264,641 -1,542 263,099 231,196 -459 230,737

Amounts in NOK 1,000

Statement of comprehensive income 31.12.2018
As reported Adjustments Without
adjustments
Sales revenues, see Note 3 173,237 -1,846 171,391
Signing fees and milestone revenues, see Note 3 8,273 -3,378 4,896
Cost of goods sold -17,147 -17,147
Gross profit 164,363 -5,224 159,140
Total operating expenses -188,066 1,064 -187,002
Operating profit before restructuring -23,703 -4,160 -27,863

Photocure has implemented IFRS 9 Financial Instruments from 1 January 2018. Based on the contracts, financial assets and liabilities currently held by the Group, the impact on Photocure's financial statements is evaluated to be insignificant. The impact 1 January 2018 of changing from the incurred loss model under IAS 39 to the expected loss model under IFRS 9 on trade receivables, amounts to NOK 0.2 million. As of 31 December 2018 the expected loss in the Group is estimated to be NOK 0.3 million and the increase of expected loss is disclosed under Adjustments in Total operating expenses.

COST OF GOODS SOLD

5

Total cost of goods sold include direct materials, services provided by contract manufactures and packaging suppliers, products freights and distribution costs. In addition are royalties for in licensing of technology and rights from other parties included.

INCOME STATEMENT CLASSIFIED BY NATURE

Amounts in NOK 1,000 Group Parent
Note 2018 2017 2018 2017
Sales revenues 2 173,237 149,181 114,950 109,277
Signing fees and milestone revenues 2 8,273 1,730 8,273 1,730
Cost of goods sold -17,147 -12,011 -16,837 -11,677
Gross profit 164,363 138,900 106,386 99,330
Other income 0 0 2,337 668
Payroll expenses 7 -99,369 -96,271 -54,785 -53,597
R&D costs excluding payroll expenses/other operating expenses -3,742 -12,999 -3,742 -12,999
Ordinary depreciation and amortisation 14 -13,211 -12,108 -12,968 -12,000
Other operating expenses -71,744 -62,725 -41,849 -49,048
Total operating expenses recurring -188,066 -184,103 -111,007 -126,976
Operating profit / loss (-) before restructuring -23,703 -45,203 -4,621 -27,646
Specification of Other operating expenses: 2018 2017 2018 2017
Marketing expenses 15,601 10,760 6,335 5,248
Profit split coverage US - - 13,390 9,942
Travel expenses 17,297 13,852 3,447 4,411
Patent costs, legal and other fees 22,248 19,957 15,728 15,066
Other expenses 16,598 18,156 2,949 14,381
Total other operating expenses 71,744 62,725 41,849 49,048

PERSONNEL EXPENSES

7

Amounts in NOK 1,000 Group Parent
Note 2018 2017 2018 2017
Salaries 86,592 74,790 39,346 37,425
Employer's social security contributions on salaries, etc. 9,824 7,553 5,817 5,228
Option costs incl employer's social security contributions 595 716 595 489
Pension costs 8 5,160 4,359 3,628 3,279
Other benefits 11,008 8,853 15,696 7,176
Hereoff restructuring -13,810 - -10,297 -
Total payroll expenses 99,369 96,271 54,785 53,597
No. of full-time equivalent positions 71 60 28 31

Share-based remuneration

As part of the company's incentive policy, employees have been offered share options to the company's shares (the term 'options' is also used). Allocated share options are vested over three years, one third each year. The rights are no longer valid after five years or immediately on resignation of the employee. No share options are allocated to members of the Board of Directors. For 2018 no options were granted. For 2017, NOK 1.3 million of share-based payments was been expensed, of which NOK 0.2 million applied to Photocure Inc.

6

The number of employee share options and average exercise prices for Photocure, and developments during the year:

2018 2017
Number Average exercise
price (NOK)
Number Average exercise
price (NOK)
Outstanding at start of year 737,669 35.53 951,955 36.10
Granted during the year - - 90,100 38.06
Forfeited during the year 170,367 38.02 94,627 37.35
Exercised during the year 185,434 30.18 2,667 27.39
Expired during the year - - 207,092 38.50
Outstanding at end of year 381,868 35.53 737,669 35.53
Vested options as per 31 December 367,533 36.98 591,389 34.56

The average weighted life of outstanding share options was 1.7 years at 31 December 2018 and 2.5 years at 31 December 2017. There were no options granted in 2018.

The exercise prices and the average life of outstanding share options as per 31 December 2018 were as follows:

Average remaining life No. of options Exercise price
NOK
1 year 150,168 32.78
2 year 188,700 40.15
3 year 43,000 38.06
Total 381,868

Calculation method for market value of employee share options:

The market value of share options is calculated according to the Black-Scholes method. Volatility is calculated on the basis of the development in the historical share price equal to the lifetime of the options. This assumes that historical volatility indicates future volatility, which is not necessarily the case. Strike prices are set as the listed price plus 10% at the time of allocation. Risk-free interest is based on the interest for Norwegian government bonds. Each option programme is calculated separately with the actual exercise price and duration of the programme. The exercise date for the options is calculated on the basis of historical experience in the company and is differentiated between senior management and other employees. The interest advantage is insignificant and has not been included in the accounts. The table below shows the values that have been used in the model.

2017 2016 2015
Dividends (NOK) 0.00 0.00 0.00
Expected volatility (%) 48.33 41.22 39.99
Historical volatility (%) 48.33 41.22 39.99
Risk-free interest (%) 0.87 0.48 0.95
Expected life of options (years) 3.50 3.50 3.50

PENSION COSTS

Photocure ASA has an agreement with a life assurance company concerning contribution-based pensions for Photocure's employees. The contribution plan match the revised national regulations for pension. The contributions are 6% of the employee's ordinary salary up to 7.1 times the basic amount (G) of the Norwegian National Insurance scheme, and thereafter 16% up to 12 x G. The national insurance cover pension for salaries to 7.1 G. Pension contributions are paid into the employee's contribution account with the life assurance company. As of 31 December 2018 and 31 December 2017, the company had immaterial deposits in the premium and the contribution fund.

Photocure Inc matches its employee's contribution to the 401(k) plan dollar for dollar up to 4% of salary for the employees that elect to join the plan. There is a salary maximum set by the IRS, which was \$275,000 in 2018.

Photocure has entered into pension agreements with senior management in the form of un-funded pensions for salaries exceeding coverage by insurance. This un-funded pension liability is interest-bearing.

The pension cost for the year is calculated as follows:

Amounts in NOK 1,000 Group Parent
2018 2017 2018 2017
Total pension costs, contribution scheme in life assurance 4,221 3,468 3,003 2,629
Total pension costs, company scheme 939 891 624 650
Total 5,160 4,359 3,628 3,279

10

RESTRUCTURING

Restructuring costs have been incurred with NOK 14.2 million for the year and relates to implemented headcount reductions and organizational changes. In total 6 employees including the CEO and CBO have left the Company or agreed to a severance agreement to leave before year end. The cost reductions do not relate to the commercial organization.

Included in the restructuring costs are costs related to the exit of the CEO totaling NOK 7.0 million according to the employment agreement. The CEO is entitled to continue to receive his salary for up to 24 months after the end of his period of notice. Should the previous CEO receive other income from employment in this period, any such income will be offset in full against his continued salary during the last 12 months of the period in which he continues to receive salary.

As part of the exit agreements pension coverage in the Photocure balance has been reclassified to short term liabilities with NOK 3.2 million as of December 31, 2018.

AUDITING FEES

Amounts in NOK 1,000 ex VAT Group and parent
2018 2017
Statutory auditing 361 435
Other attestation services 23 23
Other services excluding auditing 22
Tax advice 211 85
Total 617 543

FINANCIAL INCOME AND EXPENSE

Amounts in NOK 1,000 Group Parent
2018 2017 2018 2017
Interest income 1,185 2,359 1,185 2,359
Foreign exchange gains 2,467 3,590 18,236 3,590
Total financial income 3,652 5,949 19,421 5,949
Foreign exchange losses 2,192 2,107 2,192 12,629
Other financial expense 272 219 272 219
Total financial expense 2,464 2,326 2,464 12,848

The foreign exchange gain in the parent company include unrealised exchange gain of the long term loan to the subsidiary that is nominated in USD. The exchange rate NOK/USD increased to 8.76 as of December 31, 2018 compared to exchange rate of 8.24 at end of previous year. This is resulting in an unrealised gain of NOK 15.8 million in 2018 compared to a loss of NOK 10.5 million in 2017. In the consolidated accounts the unrealised gain/loss is eliminated against the change in equity as part of other comprehensive income.

TAX

12

Amounts in NOK 1,000 Parent & Group
2018 2017
Income tax expense
Tax payable -533 -
Changes in deferred tax 526 -6,883
Total income tax expense -6 -6,883
Tax base calculation
Profit before income tax 1,654 -34,546
Permanent differences *) 910 -3,618
Change in temporary differences -8,062 26,568
Utilisation of tax loss carried forward - -
Increase tax loss carried forward 5,499 11,596
Tax base 0 -
Temporary differences:
Receivables -108 -
Inventories 3,174 -2,602
Non current assets -1,164 -1,411
Long term currency loans 74,907 59,588
Provisions -13,269 -
Pensions -4,903 -4,207
Gains and loss account 39,328 49,160
Total 97,966 100,528
Tax loss carried forward -336,041 -330,542
Net temporary differences -238,076 -230,014
Deferred tax liability (asset) -52,377 -52,903
Amounts in NOK 1,000 Parent & Group
2018 2017
Reconciliation of effective tax rate
Expected income taxes at statutory tax rate 380 -8,291
Permanent differences 209 -868
Effect refund withholding tax prior year -533 -
Effect change tax rate Norway 2,381 2,300
Recognition of previously unrecognized tax losses -2,445 -25
Income tax expense -6 -6,883
Effective tax rate in % **) -0.4 % 19.9 %

Temporary differences are recognized for the parent company only and the note disclosure for the Group is of this reason identic to the disclosure for parent company. * ) Permanent differences consist of non deductible costs, non taxable income and deduction for development cost through the SkatteFunn concept.

**) Tax expense related to profit before tax.

The parent company has a taxable loss in 2018 of NOK 5.5 million compared to loss of NOK 11.6 million in 2017. Photocure apply a profit/loss split method for the business in US and a share of the US related revenue and expenses are included in the parent company. The basis for recognition of a tax asset in Norway are the predicted future profit according to the business plan for all major markets and that temporary differences for the coming years will be reversed. The deferred tax asset is of this reason maintained by NOK 52.4 million as of 31 December 2018.

It is Photocure's judgment that the operation in the US will be profitable and this will contribute to the pre-tax result in the parent company through the profit/loss split method. This is based on a cash flow model taking into account a balanced view of the market share for Cysview in the US compared to partner sales of Hexvix in Europe and Photocure's own sales in the Nordic region. The expansion of the US sales and marketing force which commenced in 2017, has continued in 2018 and enable Photocure Inc to cover larger parts of the US market in order to gain further market shares. Furthermore, in 2017 a significant milestone was reached in the US as cystoscopy with Cysview was decided to be reimbursed by the US Health Care at hospital outpatient departments from January 2018. This decision provides strong recognition of the clinical benefits of Cysview/ Hexvix and is an important foundation for future growth in the US.

Photocure continues to see growth opportunities in the Nordic and major European countries, not at least in the surveilance market with flexible cystoscopes which is 2-3 times bigger than the rigid cystoscopy market. Several studies have been published highlighting and verifying key clinical benefits including the positive impact of Hexvix/Cysview on reduced disease progression, bladder cancer detection and the safety of repeated use of Hexvix/Cysview.

The basis for the recognition of the tax asset is the assessment that there are convincing evidence that the deferred tax benefit will be utilised.

There is no expiry on losses to be carried forward in Norway while it expires after 20 years in US according to tax legislation valid to end of 2017. The new US tax legislation valid for taxable years from 2018 have no expiry of loss carried forward but a 80% limit in utilization.

Deferred tax assets have not been recognised in respect of the following items in the US subsidiary due to no history of pre-tax profit at this point in time:

Amounts in NOK 1,000 2018 2017
Unrecognised deferred tax assets Amount Tax effect Amount Tax effect
Net deductible temporary differences -1,508 -428 -1,815 -545
Tax losses 125,706 35,731 91,280 27,384
Total 124,198 35,303 89,465 26,840

Tax losses for which no deferred tax asset was recognized, expire as follows:

Amounts in NOK 1,000 2018 2017
Amount Expiry date Amount Expiry date
Expire 122,384 2030 - 2037 91,280 2030 - 2037
Never expire 3,322 - -
Total 125,706

13

EARNINGS PER SHARE

Earnings per share are calculated on the basis of the profit/loss for the year after tax but excluding other comprehensive items. The result is divided by a weighted average number of outstanding shares over the year, reduced by acquisition of treasury shares. The diluted earnings per share is calculated by adjusting the average number of outstanding shares by the number of employee share options that can be exercised. Antidilution effects are not taken into consideration.

2018 2017
Figures indicate the number of shares
Ordinary shares 1 January 21,557,910 21,557,910
Effect of treasury shares -9,616 -809
Effect of share options exercised 17,781
Effect of shares issued 16,905
Weighted average number of shares, 31 December 21,582,980 21,557,101
Effect of outstanding share options 47,512 10,175
Weighted average number of diluted shares, 31 December 21,630,492 21,567,276
Amounts in NOK 1,000 2018 2017
Net profit/loss(-) -36,708 -34,697
Earnings per share
Earnings per share in NOK basic -1.70 -1.61
Earnings per share in NOK diluted -1.70 -1.61

INTANGIBLE ASSETS, MACHINERY AND EQUIPMENT

Amounts in NOK 1,000
Intangible assets Machinery and Equipment
Group Product
Development
Software
Systems
Total Production Office Total
Accumulated cost at 31 December 2016 32,972 2,811 35,783 3,324 5,145 8,469
Additions 17,538 622 18,160 0 428 428
Disposals and scrapping 0 0 0 0 -350 -350
Accumulated cost at 31 December 2017 50,510 3,433 53,943 3,324 5,223 8,547
Additions 559 237 796 228 1,328 1,556
Disposals and scrapping 0 0 0 -3,324 -76 -3,400
Accumulated cost at 31 December 2018 51,069 3,670 54,739 228 6,475 6,703
Accumulated depreciation at 31 December 2016 9,346 47 9,393 2,932 3,877 6,809
Amortization and depreciation 10,673 562 11,235 392 481 873
Disposals and scrapping 0 0 0 0 -403 -403
Accumulated depreciation at 31 December 2017 20,019 609 20,628 3,324 3,955 7,279
Amortization and depreciation 10,943 665 11,608 13 1,590 1,603
Disposals and scrapping 0 0 0 -3,324 -996 -4,320
Accumulated depreciation at 31 December 2018 30,962 1,274 32,236 13 4,549 4,562
Book value at 31 December 2018 20,107 2,396 22,502 215 1,926 2,141
Book value at 31 December 2017 30,491 2,824 33,315 0 1,268 1,268

The note for parent company has immaterial differences to the group and is not disclosed of this reason.

The Group cannot render probable future earnings large enough to justify recognizing development costs for pharmaceuticals and medical equipment in the balance sheet before marketing approval has been obtained. Own development costs are therefore recognized as an expense until national market approval for the product and indication has been granted. Development expenditures for the product after marketing approval has been obtained and market launch is completed, may be recognized in the balance sheet. The premise of this presentation is based on development that involves significant changes to the product, which is considered likely to generate future financial benefits.

Photocure has from 2015 carried out a clinical study in US for the approved product Cysview in order to obtain a marketing approval for repeated use and use in combination with flexible cystoscopies in US. Photocure has in 2018 capitalized NOK 0.4 million in the balance sheet and accumulated NOK 46.2 million as of 31 December 2018 for these development expenditures. The development expenditures are amortized on a straight-line basis in the profit and loss from the start of the expenditure project over the remaining patent period for the approved product and indication.

The study addressed safety and efficacy questions regarding repeat use of Cysview and safety and efficacy in the detection of pre-cancerous lesions (CIS). In addition to fulfill the post marketing commitments in US, the results of the study has been used to expand the indication for use of Cysview. The study was completed in 2017 and the application for the fullfillment of the post marketing committments and expanded indications was filed with FDA in August 2017. Photocure has in February 2018 received an unconditional approval from FDA. The supplier of the flexible scope has also filed and received approval for their flexible scope that in US is required for the use of Cysview.

Group Parent
Rental costs 2018 2017 2018 2017
Rental of office premises 4,152 3,808 3,047 2,893
Rental of equipment 1,430 912 1,378 861
Total rental costs 5,583 4,720 4,425 3,754

The parent company has a rental agreement for premises at Hoffsveien 4 in Oslo ending August 2021. The agreement include a right to sub rent part of the premises and this right has been utilised. The net rent amounts to NOK 2.5 million for the period 1 January 2019 through 31 December 2019. The net rent for the remaining period until the expiry of the agreement amounts to NOK 4.2 million. Annual regulation of the rent corresponds to the change in the consumer price index.

Photocure Inc rents office premises at Carnegie Center, Princeton, New Jersey from 1 April 2011 through 10 December 2022. Photocure Inc utilised in 2017 an option to increase the space leased by 551 feet and to extend the agreement until 10 December 2022. The rent commitment for the period 1 January 2019 to 31 December 2019 is NOK 1.1 million while the rent for the remaining period until the expiry of the agreement amounts to NOK 3.4 million.

Rental of equipment comprises medical treatment equipment located at hospitals and office equipment. All rental agreements for equipment are short-term.

OTHER INVESTMENTS

In the balance sheet of parent company 100% of shares in the subsidiary Photocure Inc are included with book value NOK 5.5 million as of 31 December 2018 and NOK 5.5 million as of 31 December 2017.

INVENTORIES

Amounts in NOK 1,000 Group Parent
31-Dec-18 31-Dec-17 31-Dec-18 31-Dec-17
Raw materials 1,095 1,526 1,095 1,526
Resale products 71 0 71 0
Semi-finished and finished goods 17,417 18,026 16,682 17,470
Total inventories 18,583 19,552 17,848 18,996

The raw materials inventory consists of active substances for the pharmaceutical products. Raw materials are valued at cost. Finished and semi-finished goods are valued at full manufacturing cost. Consumption is carried out in accordance with the FIFO principle. Obsolete goods are written down to net relisable value. Provisions and write-downs of inventories are included in cost of goods sold in the income statement.

Stock of resale products comprises from 2018 medical disposable equipment according to the distribution agreement with Combat Medical for the bladder chemoterapy business.

In April 2017, the Board of Directors announced that the Company should carry out a broad review of possible strategic alternatives for its non-urology assets, Cevira® and Visonac®, in parallel with ongoing partner search. The impact of this decision was to write down the inventory of components by NOK 4 million. The write-down are included in the R&D expenses for 2017.

FINANCIAL RISK

The note describes the company's various financial risks and the management of same. In addition, numerical presentations of risk associated with financial risks are included.

(I) Organisation of financial risk management

Photocure has an international business operation and is exposed to currency risk, interest rate risk, commodity price risk, liquidity risk and credit risk. Responsibility for managing financial risk is placed with the management of the company, including financing, interest rate and currency management as well as risk within the business areas and the risk associated with the company's business processes. Financial risk is also monitored by the Board of Directors.

Centralised risk management

Photocure has a centralised finance department. This department ensures the company's financial freedom to act both long and short term, and to monitor and manage financial risk in collaboration with the individual business units within the company. The finance department maintains communication with the company's bank connections, and carries out hedging transactions regarding interest and currency. Required authorisations for borrowing and entering into derivative agreements are to be granted by the Board of Directors. All transactions involving financial instruments are backed by an underlying commercial hedging requirement.

Commercial operations – production, sales and marketing

Photocure manufactures, markets and sells the company's products through own sales organization in the Nordic region and US and through license partners in other countries. Revenues from license partners consist of three elements: sales of products to license partners, royalties from license partners' sales to end users, and milestone revenues. Photocure manufactures the company's products by renowned contract manufacturers in Italy, Spain, Netherland and Austria. Prices of raw materials is a risk factor. Currency risk is mainly related to milestone revenues, sale to partner and royalties which mainly is nominated in EUR and USD. Also Photocure's commercial operations in the US expose Photocure for currency risk against USD as both revenues and expenses are in USD. Currency risks are partly naturally hedged by purchasing goods and services in EUR and USD.

(II) Classes of financial risk

Interest rate risk

Photocure does not have any interest-bearing debt with exception for pension liability, and the company's interest rate risk is mainly associated with the company's holdings of cash and cash equivalents. The main strategy is to diversify the risk and invest in money market funds and bond funds with low risk, high liquidity and short duration. More than 90% of the investments are denominated in NOK and are not hedged.

Liquidity risk

A main objective of Photocure's financial policy is to ensure that the company has the financial freedom to act both short and long term to achieve strategic and operational goals. Photocure is to have sufficient funds to cover known capital requirements during the forthcoming 12 months in addition to a strategic reserve. The Company monitors the cash flows on long and short term through planning and reporting. Photocure does not have any loan agreements that involve covenants or other financial requirements.

Photocure uses a multi-currency consolidated accounts system that provides flexibility in relation to drawing on multiple currencies.

The following table presents an overview of the maturity structure of the company's financial obligations, based on non-discounted contractual payments:

Amounts in NOK 1,000 Remaining period
Less than
1 month
1–3 months 3–12 months 1–5 years Total
31-Dec-18
Accounts payable 9,682 500 10,182
Withholding tax and social securities 2,653 1,690 4,343
Other current liabilities 8,364 9,000 12,500 1,000 30,864
31-Dec-17
Accounts payable 14,081 1,000 15,081
Withholding tax and social securities 1,640 2,054 3,694
Other current liabilities 3,492 7,500 9,500 1,000 21,492

Credit risk

Management of credit risk associated with accounts receivable and other operational receivables is dealt with as a part of the commercial risk and is followed up continuously as a part of normal operations. Photocure is primarily exposed to credit risk associated with accounts receivable and other short-term receivables. Photocure's sales are made to license partners, pharmaceutical wholesalers in the Nordic region and hospitals in USA. The credit risk is limited as the counterparties are maily large companies that are not related to each other. Photocure's credit risk is considered moderate and the Company does not use credit insurance.

Currency risk

As NOK is the Company's presentation currency, Photocure is exposed to translation risk associated with the company's foreign net exposure. Photocure's revenues and costs are incurred in different currencies, primarily EUR, USD, GBP, SEK and DKK. Photocure is therefore exposed to exchange rate fluctuations. The company regularly monitors the need for hedging of large transactions. Bank accounts in foreign currencies are used actively to reduce exposure to all the main currencies, and currency risk is to some degree naturally hedged in EUR, USD, SEK and DKK by having both revenues and costs in the same currency. However Photocure had a cash surplus in EUR and a cash deficit in USD.

The following table shows the Company's sensitivity for potential changes in the NOK exchange rate with all other factors constant. The calculation is based on the same change in relation to all relevant currencies. The effect in the income statement comes from changes in the value of monetary items.

Amounts in NOK 1,000 Change in the NOK
exchange rate
Effect on operating
profit/loss
2018 + 10 % -4,105
2018 - 10 % 4,105
2017 + 10 % -4,600
2017 - 10 % 4,600

FAIR VALUE

18

The table below analyses financial assets recognised in the balance sheet at fair value according to the valuation method.

The different levels have been defined as follows:

  • Level 1: Noted prices in active markets for corresponding assets or liabilities
  • Level 2: Available value measurements other than the noted prices classified as Level 1, either directly observable in the form of agreed prices
  • or indirectly as derived from the price of equivalent.
  • Level 3: Value measurements of assets or liabilities that are not based on observed market values
Amounts in NOK 1,000
Market value hierarchy Level 1 Level 2 Level 3 Total
Money market funds 79,114 79,114
Total 79,114 - - 79,114

19 RECEIVABLES

Maximum credit risk

The company's maximum credit risk associated with financial instruments corresponds to gross receivables. In a hypothetical situations, where no receivables are actually paid, this would correspond to:

Amounts in NOK 1,000 Group Parent
31-Dec-18 31-Dec-17 31-Dec-18 31-Dec-17
Accounts receivable 20,371 14,573 10,645 8,203
Accounts receivable intercompany 579 224
Total 20,371 14,573 11,224 8,427
Royalty 4,495 4,548 4,495 4,548
Other receivables 3,148 7,572 904 6,482
Total other receivables 7,643 12,119 5,399 11,030

Loan to the subsidiary is disclosed in note 25.

Age breakdown of group accounts receivable Not yet due 0–30 days 30–60 days 60–90 days Over 90 days Total
31 December 2018 15,823 3,666 730 152 20,371
31 December 2017 10,617 2,918 364 89 585 14,573

The impact 1 January 2018 of changing from the incurred loss model under IAS 39 to the expected loss model under IFRS 9 on trade receivables, amounts to NOK 0.2 million. As of 31 December 2018 the expected loss in the Group is estimated to be NOK 0.3 million. Realised bad debt loss' in 2018 and 2017 have been immaterial. Credit risk and foreign exchange risk in regard to trade accounts receivable are dealt with in more detail in Note 17.

20

CASH AND SHORT TERM DEPOSITS

Amounts in NOK 1,000 Group Parent
31-Dec-18 31-Dec-17 31-Dec-18 31-Dec-17
Cash and cash equivalents, restricted (1) 4,330 4,073 4,330 4,073
Cash and cash equivalents, non-restricted 23,389 24,312 22,516 23,935
Money market funds, non-restricted 79,114 100,983 79,114 100,983
Total 106,833 129,368 105,960 128,991

(1) Restricted cash and cash equivalents at 31 December 2018 include security for employees' withholding tax in of NOK 1.9 million, while the remaining amount refers to deposit for rent of office.

SHARE CAPITAL

Registered share capital in Photocure ASA amounted to:

No. of shares Nominal value
per share NOK
Share capital
in NOK
Share capital at 31 December 2017 21,557,910 0.50 10,778,955
Share capital at 31 December 2018 21,779,008 0.50 10,889,504
Treasury shares:
Holdings of treasury shares at 31 December 2016 809 405
Buy-back of treasury shares 0 0.50 0
Share option exercise 0 0.50 0
Holdings of treasury shares at 31 December 2017 809 405
Buy-back of treasury shares 13,000 0.50 6,500
Buyback of restricted shares 1,121 0.50 561
Holdings of treasury shares at 31 December 2018 14,930 7,465

All shares have the same voting rights and otherwise the same rights in the Company. Ordinary shares are classified as equity. Expenses that are directly attributable to the issue of ordinary shares are included as a reduction of equity.

At the General Meeting 9 May 2018, the Board of Directors of Photocure ASA was granted authorisation to issue up to 3.2 million shares. Of this authorisation, (a) 2.16 million shares are linked to financing of the Company's development, while (b) 1.08 million shares are associated with the issue of shares to the Company's employees. Subscription of shares under the incentive program shall be subscribed at the market price with an addition of 10% at the time of allocation of the employee share options. At the General Meeting the Board of Directors was granted authorisation to purchase treasury shares to a total nominal value of up to 10% of the applicable share capital. The basis for this authorisation to purchase treasury shares is the desire by the Board of Directors to increase the liquidity of the Company's shares and in connection with the incentive schemes.

All authorisations are valid up until the Ordinary General Meeting in 2019. Previously issued authorisations have expired.

The table below indicates the status of authorisations at 31 December 2018:

Figures indicate the number of shares Purchase, treasury
shares
Ordinary share issue Employee share issues
Authorisation issued at the General Meeting on 9 May 2018 2,155,791 2,155,791 1,077,895
Share issues after the General Meeting on 9 May 2018 0 0 185,434
Purchase of treasury shares after the General Meeting 9 May 2018 -1,121 0 0
Remaining under authorisations at 31 December 2018 2,154,670 2,155,791 892,461

381 868 share options have been allocated to employees 31 December 2018 (see note 7).

Ownership structure

The major shareholders in Photocure as of 31 December 2018 were:

Shares Shareholding
High Seas AS 2,220,000 10.2 %
Fondsfinans Norge 975,000 4.5 %
KLP Aksjenorge 930,062 4.3 %
Radiumhospitalets Forskningsstiftelse 693,319 3.2 %
Kommunal Landspensjonskasse 679,994 3.1 %
Mp Pensjon PK 674,355 3.1 %
Myrlid AS 585,000 2.7 %
Nordnet Livsforsikring AS 409,871 1.9 %
Danske Bank A/S 360,811 1.7 %
Bnp Paribas Securities Services 356,186 1.6 %
Vicama AS 329,530 1.5 %
Polar Capital Global Healthcare 254,537 1.2 %
Rul AS 244,451 1.1 %
Fondsfinans Global Helse 234,490 1.1 %
Egeland Holding AS 230,000 1.1 %
Lehre Holding AS 212,731 1.0 %
Billington 190,000 0.9 %
Nordnet Bank AB 189,523 0.9 %
A/S Skarv 150,000 0.7 %
Pibco AS 140,000 0.6 %
Total of 20 largest shareholders 10,059,860 46.2 %
Treasury shares 14,930 0.1 %
Total other shareholders 11,704,218 53.7 %
Total number of shares 21,779,008 100.0 %

Shares owned, directly or indirectly, by members of the Board of Directors, the President and CEO and senior management and their closely related associates as of 31 December 2018:

Restricted No. of share
Name Position No. of shares shares options*
Jan H. Egbert Chairperson of the board 14,500 - -
Gwen Melincoff Board member 1,000 - -
Tom Pike Board member 3,400 - -
Daniel Schneider President and CEO 15,000 - -
Ambaw Bellete Head, US Cancer Commercial Operations 3,600 5,551 22,500
Erik Dahl Chief Financial Officer 3,500 5,046 49,500
Grete Hogstad Vice President Strategic Marketing 13,878 4,025 45,000
Espen Njåstein Head, Nordic Cancer Commercial Operations 8,378 2,691 51,100
Gry Stensrud Vice President Technical Development & Operations 1,845 3,803 53,300

* See note 7 for additional information about the share options.

22

CAPITAL STRUCTURE

The Group is financed by equity and had no interest-bearing debt at 31 December 2018 and 31 December 2017 with exception for the pension liability according to note 8.

23

ACCOUNTS PAYABLE AND OTHER CURRENT LIABILITIES

Amounts in NOK 1,000 Group Parent
31-Dec-18 31-Dec-17 31-Dec-18 31-Dec-17
Accounts payable 10,182 15,081 7,638 13,394
Accounts payable, intercompany 1,344 943
Total 10,182 15,081 8,982 14,338
Accrued bonus, holiday pay, salaries 19,031 15,487 12,272 12,661
Accrued royalty liability 1,630 1,153 1,630 1,153
Short term portion of pension liability 3,179 - 3,057 -
Miscellaneous other accrued costs 7,025 4,852 6,075 4,436
Total other current liabilities 30,864 21,492 23,033 18,250

Accrued royalty liability concerns agreements with external parties for the right to use patented technology. The liability is calculated as royalty on sales of products accrued in the last period and as a share of any signing fees and milestone payments received. Accrued bonus, holiday pay, salaries include accrual for restricted share allotment with NOK 3.452 as of 31 December 2018 compared to NOK 4,588 previous year end. Final allotment for the Group to be decided by the Board of Directors.

24

REMUNERATION OF MANAGEMENT AND BOARD OF DIRECTORS

Amounts in NOK 1,000 Restricted
share
Directors'
fees paid
Salaries
paid
bonuses
accrued
Bonuses
accrued
Benefits in
kind
Pension
cost
Total
Senior management 2018
President and CEO until June 2018 1,274 - - 264 401 1,939
President and CEO from November 2018 *) 2,229 1,041 92 - 147 3,509
Chief Business Officer until May 2018 *) 1,233 - - 91 114 1,438
VP Research and Development until November
2018
1,058 - 66 360 97 1,580
Chief Financial Officer 1,833 146 143 156 235 2,513
VP Strategic Marketing 1,526 107 132 216 197 2,178
VP Technical Development and Operations 1,345 107 115 19 160 1,746
Head, US Cancer Commercial Operations *) 2,890 130 373 462 229 4,084
Head, Nordic Cancer Commercial Operations 1,395 80 135 146 170 1,926
Total senior management 14,783 1,612 1,055 1,713 1,750 20,913
Board of Directors 2018
Chairperson of the Board 486 486
Members of the Board 1,680 1,680
Total remuneration 2,166 14,783 1,612 1,055 1,713 1,750 23,079
*) Remunerations paid in USD:
President and CEO 274 128 11 - 18 431
Chief Business Officer until May 2018 152 - - 11 14 177
Head, US Cancer Commercial Operations 355 16 46 57 28 502

Key mangement and Directors transactions

The Group used the professional services of its Chairperson of the Board and one of its Directors in relation to consulting services during 2018. The consulting services relates to work beyond regular board duties. Contracts are based on market rates and conditions for such services. The amount billed by the Director of USD 7.5 thousands was paid by Photocure in 2019. The amount billed by the Chairperson of NOK 146 thousands was paid by Photocure in 2018.

Directors' Bonuses Benefits in
Amounts in NOK 1,000 fees paid Salaries paid accrued kind Pension cost Total
Senior management 2017
President and CEO 2,552 586 88 407 3,632
Chief Business Officer from May 2017 *) 1,848 334 677 120 2,978
VP Research and Development 1,285 147 88 123 1,643
Chief Financial Officer 1,712 205 18 229 2,164
VP Strategic Marketing 1,497 176 93 194 1,960
VP Technical Development and Operations 1,296 163 18 146 1,623
Head, US Cancer Commercial Operations *) 2,818 465 217 219 3,718
Head, Nordic Cancer Commercial Operations 1,386 193 20 162 1,761
Total senior management 14,393 2,268 1,218 1,599 19,480
Board of Directors 2017
Chairperson of the Board 470 470
Members of the Board 1,080 1,080
Total remuneration 1,550 14,393 2,268 1,218 1,599 21,030
*) Remunerations paid in USD:
Chief Operating Officer 223 40 82 15 360
Head, US Cancer Commercial Operations 341 56 26 26 449

Key mangement and Directors transactions

The Group used the professional services of its Chairperson of the Board and one of its Directors in relation to consulting services during 2017. The consulting services relates to work beyond regular board duties. Contracts are based on market rates and conditions for such services. The amount billed by the Director of NOK 183 thousands was paid by Photocure in 2017.

THE BOARD OF DIRECTORS' DECLARATION ON DETERMINATION OF SALARIES AND OTHER REMUNERATION FOR SENIOR MANAGEMENT 2019

1. General

This declaration is prepared by the board of directors in Photocure ASA ("Photocure" or the "Company") in accordance with the Norwegian Public Limited Liability Companies Act (the "Companies Act") section 6-16a, for consideration at the annual general meeting on 9 May 2019.

Principles in this declaration regarding allocation of shares, subscription rights, options and any other form of remuneration stemming from shares or the development of the official share price in the Company are binding on the board of directors when approved by the general meeting. Such guidelines are described in section 3.2. Other guidelines are precatory for the board of directors. If the board of directors decides to deviate from these guidelines, the reasons for this change shall be stated in the minutes of the board of directors' meeting.

The principles set out for the determination of salaries and other remuneration for senior management in this declaration shall apply for the financial year 2019 and until new principles are resolved by the general meeting in accordance with the Companies Act. The annual general meeting in 2020 will review how the principles set out in this declaration have been pursued in 2019 and deal with the principles for 2020 in accordance with the Companies Act.

2. Main principles

Senior management remuneration in Photocure and group companies shall be determined based on the following main principles:

2.1 Remuneration shall be competitive, but not leading

Senior management remuneration shall, as a general guideline, be suited to attract and retain skilled leaders in order to enhance value creation in the Company and support the alignment of interests between management and shareholders. Total remuneration should, as a general rule, be at level with remuneration for senior management in comparable industries, businesses and positions in the country in which the individual manager resides.

2.2 Remuneration shall be motivational

Senior management remuneration shall be structured to drive motivation and encourage improvements in results and shareholder value. In general, the remuneration consists of five elements: base salary, short term incentives, long term incentives, benefits in kind and pension benefits.

The variable remuneration, short term and long term, is linked to value generation for shareholders over time. The variable remuneration is determined both by the achievement of individual and companywide key performance indicators and goals. Instrumental is that senior managers, both individually and as a team, can influence achievement of the key performance indicators and goals.

The long term incentives are tied to the development of the share price of the Company and in accordance with section 3.2 of this declaration.

2.3 Remuneration shall be comprehendible and acceptable both internally and externally

The remuneration system shall not be unduly difficult to explain to the general public and should not involve disproportional complexity for the administration.

2.4 Remuneration shall be flexible, allowing adjustments over time

To be able to offer competitive remuneration, the Company must have a flexible system that can accommodate changes as the Company and markets evolve.

3. Principles regarding benefits offered in addition to base salary

The base salary is the main element of the senior manager's remuneration. Additional and variable remuneration elements are, at time of grant, subject to determination of specific maximum amounts depending on the position of the employee.

The following refers to the individual benefits which are granted in addition to base salary. Unless specifically mentioned, no special terms, conditions or allocation criteria apply to the benefits mentioned.

3.1 Additional benefits

3.1.1 Short term incentive / cash bonus scheme

The Company has established a bonus scheme for senior management. These schemes are reviewed at least annually. Bonus schemes are tied to the achievement of operational and financial goals for the Company determined by the board of directors and achievement of personal goals. Personal goals for senior management are approved by the board of directors at the start of the year.

The Chief Executive Officer of the Company has a bonus agreement of up to 40% of base salary, while other members of the senior management team have bonus agreements from 20% to 35% of their base salary.

3.1.2 Pension plans and insurance

Senior managers in Norway participate in Photocure ASA's pension scheme, which is a contribution scheme that involves payment of between 6% and 16% of the employee's base salary up to 12 times the basic amount (G) of the Norwegian National Social Security Scheme (Folketrygden). Photocure has established pension coverage for senior management for salary above 12 G. The scheme is a contribution-based operating pension with provisions corresponding to 16% of salary above 12 G. In the event of resignation, full pension rights are conditional upon at least five years' employment, while less than 3-years' employment carries no rights. The pension schemes also cover in the event of disability.

Senior managers residing in the United States participates in a 401(k), a tax-qualified, defined-contribution pension account defined in subsection 401(k) of the Internal Revenue Code. In addition, Photocure Inc. has established an additional pension coverage contributing annually an amount equal to 4% of salary and earned bonus.

The Company compensates senior management for health and life insurance plans in line with standard conditions for senior positions, in addition to mandatory occupational injury insurance required under Norwegian law.

3.1.3 Severance schemes

The Chief Executive Officer has a period of notice of thirty (30) days. In addition, and in accordance with detailed regulations, the Chief Executive Officer is entitled to a lump sum amount equal to 12 months of his base salary and prorated performance bonus adjusted for degree of bonusobjectives achieved at time of termination and also a lump sum related to a health care premium calculated for 12 months of coverage. Other senior management has a period of notice between 3 and 12 months.

3.1.4 Benefits in kind

Senior managers will normally be given the benefits in kind that are common market practice, i.e., telephone expenses, a laptop, free broadband connection, newspapers and car allowance if applicable. There are no special restrictions on the type of other benefits that can be agreed on.

3.1.5 Loans and guarantees

No loans are granted, nor are any securities provided for members of the senior management team, the board of directors, employees or other persons in elected corporate bodies.

3.1.6 Other benefits

It may be used other variable elements in the remuneration or awarded other special benefits than those mentioned above, provided that this is considered expedient for attracting and/or retaining a manager. No special limitations have been placed on the type of benefits that can be agreed.

3.2 Binding principles for shares and other types of benefits related to shares or share price trends

The Company operates an equity-settled, share-based compensation plan for its senior managers and selected personnel.

The existing restricted shares program shall be replaced with a share option program. The option program is designed to create an ownership culture to ensure alignment between shareholders and senior employees of the Company. The program is an important tool to attract and retain high caliber employees as the Company has transformed itself from a technology-based company to a therapeutic area-focused commercial stage pharmaceutical company with focus on bladder cancer. In particular, the Company needs to adjust compensation structure to the regions where it operates. As the largest growth potential for the Company is in U.S., the Company needs to adjust to U.S. practices. Furthermore, the restricted shares program is not tax effective and has been difficult to implement for U.S. based employees.

Senior management and selected employees will be eligible for option awards, including new hires, as decided by the board of directors. Awards will be on a discretionary basis taking into account performance, organizational level and position, and importance of retention. Evaluation of performance will be based on the achievement of Company and individual goals. The option program has a performance-based remuneration element reflecting the underlying long term value creation of the Company. The board of directors shall, amongst others, take into consideration the Company's goals, strategies and performance as well as targeted individual performance for each participant. Depending on goal achievement, senior management (CEO and currently 6 direct reports) are for 2019 expected to be awarded 50-70% of total Company award. Total Company award will depend on goal achievement.

Company goals are mainly financial and related to growth and profitability, as are individual goals designed for the specific position. For 2019, Company goals are 85% related to revenue growth and EBITDA and 15% related to specific strategic initiatives. Individual performance goals for 2019 are position specific and designed to support achievement of Company goals. All individual goals for senior management are approved by the board of directors.

Senior management are for 2019 measured as follows:

  • CEO: Company goals 100%
  • CFO: Company goals 70% / Individual goals 30%
  • Other senior management: Company goals 50% / Individual goals 50%

The terms for the options for each individual, including any limits, are determined by the board of directors within the board of director's authorizations as resolved by the Company's general meeting. The board of directors will exercise discretion as to who will receive an equity award in any given year. This decision is based on recommendations made by the compensation committee. Awards will normally be granted on an annual basis based on Company performance and within the maximum size of the awards approved at the Company's annual general meeting. The number of outstanding options shall not exceed 9 % of the Company's total outstanding shares at any point in time.

The intention is that options will be granted annually with a strike price based on the weighted average share price 10 trading days prior to the grant with an additional premium of 10% on top of the calculated average price. Grants may also be made in connection with new recruitments. The share options shall vest over three years, with 25% vesting after one year, 25% after two years, and the remaining 50% after three years. Any non-exercised options expire five years after grant.

To avoid the risk of extreme payouts, the options shall have a cap on the maximum pay out of the share option. This cap shall equal 7 times the stock price at the time of grant.

To ensure long term ownership, shares following exercise of options shall be held for at least 2 years after exercise, except shares to be sold to cover costs including purchase amount and tax.

In case of termination of employment, all options unvested as well as vested but not exercised at the time of expiry of employment will lapse. If the option holder is dismissed, unvested options as well as vested but not exercised options will lapse upon dismissal, unless the board of directors decides otherwise.

The option strike price may be subject to adjustments in the event of share split, combination of shares, dividend payment and/or other distribution. In the event of change of control or a merger the options may vest in full.

The board of directors shall decide the further terms and conditions for the share options.

Proposed authorization

To recruit and retain experienced managers and key employees to support the commercial activities and growth, particularly in U.S., the Company needs to offer competitive compensation. The option program is an important element of this.

The board of directors proposes that the 2019 annual general meeting authorizes the board of directors to grant, during the period from the 2019 annual general meeting until the 2020 annual general meeting, up to 500,000 options including assumed 100,000 options for new key employees as determined by the board of directors. Maximum award requires full achievement of Company goals as well as all individual goals as outlined in this guideline.

4. Remuneration to senior managers in other Photocure companies

All companies in the Photocure group are to follow the main principles for the determining of senior management salaries and remuneration as set out in this declaration. Photocure aims at coordinating management remuneration policy and the schemes used for variable benefits throughout the group.

5. Statement on executive salary policy and consequences of agreements on remuneration in the previous financial year

Remuneration, including pension and insurances, severance schemes, benefits in kind and other benefits granted to senior management are discussed in note 24 to the annual accounts for the financial year 2018.

The annual report and annual accounts for 2018 are available on the web site of the Company, www.photocure.com.

The agreements entered into with senior management during the financial year 2018 are entered into in accordance with the principles for determining senior management salaries and remuneration as approved by the general meeting in 2018.

The board of directors believes that the guidelines for share-based remuneration promote value creation in the Company and that the impact they have on the Company and shareholders is positive."

Senior managers' holdings of shares in Photocure ASA are stated in the note concerning share capital. Allocation and exercise of Share options to shares and holdings of Share options for senior managers are presented in the following overview:

Share options for senior management 2018 Share options
awarded
Expired share
options
Share options
exercised
Holding of share
options at 31
December 2018
Average
exercise price
President and CEO - - - - -
Chief Financial Officer - - 14,000 49,500 36.58
VP Strategic Marketing - - 13,000 45,000 36.22
VP Technical Development and Operations - - - 53,300 36.42
Head, US Cancer Commercial Operations - - 38,800 22,500 40.15
Head, Nordic Cancer Commercial Operations - - 13,000 51,100 36.79
Total - - 78,800 221,400
Share options for senior management 2017 Share options
awarded
Expired share
options
Share options
exercised
Holding of share
options at 31
December 2017
Average
exercise price
President and CEO - 21,000 - 72,500 36.08
Chief Financial Officer - 30,000 - 63,500 34.55
VP Strategic Marketing - 19,800 - 58,000 34.24
VP Research and Development - 20,280 - 70,300 34.39
VP Technical Development and Operations - 20,550 - 53,300 36.42
Head, US Cancer Commercial Operations - 15,300 - 61,300 34.25
Head, Nordic Cancer Commercial Operations - 16,350 - 64,100 34.88
Chief Business Officer - - - 0.00
Total - 143,280 - 443,000

RELATED PARTIES - COMPANIES

Subsidiary

Photocure has established a wholly owned subsidiary in the US, Photocure Inc, in order to carry out the marketing-, selling- and distribution activities for the Cysview product from 2012. Photocure ASA has the ownership to the patent rights and the trade mark and is responsible in the Group for development and manufacturing of the product.

Photocure Inc purchases the completed product from the parent company and distributes in the United States. The transfer price method implemented is the profit & loss split method (PSM). The PSM divides the combined profit or loss between the transacting related entities based on what would be anticipated if the entities had been transacting at arm's length. A contribution analysis for sale of Cysview compares the split of profit or loss between Photocure Inc and Photocure ASA based on the value of the functions performed by each of the related parties, taking account of assets used and the risks assumed by both parties.

Photocure Inc has established its own marketing organization that is funded by a loan from its parent company in addition to its own revenues. The transactions between Photocure ASA and Photocure Inc are on terms at arm's length, except for the loan that is interest free until further notice.

It is Photocure's judgment that the operation in the US will be profitable. This is based on a cash flow model taking into account a balanced view of the market share for Cysview in the US compared to partner sales of Hexvix in Europe and Photocure's own sales in the Nordic region. The expansion of the US sales and marketing force which commenced in 2017, has continued in 2018 and will enable Photocure Inc to cover larger parts of the US market in order to gain further market shares. Furthermore, in 2017 a significant milestone was reached in the US as cystoscopy with Cysview was decided to be reimbursed by the US Health Care at hospital outpatient departments from January 2018. This decision provides strong recognition of the clinical benefits of Cysview/Hexvix and is an important foundation for future growth in the US.

The application for the fullfillment of the post marketing committments for US market approval and expanded indications that was filed in 2017, has been approved by FDA in February 2018. The approval expands the indication in the current rigid setting by including the detection of pre-cancerous leasons in bladder cancer patients as well as the repeat use of Cysview.

Amounts in NOK 1,000
Transactions and intercompany balances Photocure Inc: 2018 2017
Sales of products 5,363 2,539
Sales of services 2,337 668
Total subsidiary 7,700 3,207
31-Dec-18 31-Dec-17
Accounts receivables 579 224
Long term loan given 266,964 227,467
Accounts payables -1,344 -943
Total subsidiary 266,200 226,748
Guarantees to bank in favor of subsidiary for requested security 2,058 1,936

These are for licenses with the States of Maryland, Mississippi and California to sell Cysview and for the office lease deposit.

SUBSEQUENT EVENTS

There are no subsequent events after 31 December 2018 that give material impact to the Group financial position as of the balance sheet date.

KPMG AS Sørkedalsveien 6 Postboks 7000 Majorstuen 0306 Oslo

Telephone +47 04063 Fax +47 22 60 96 01 Internet www.kpmg.no Enterprise 935 174 627 MVA

To the General Meeting of Photocure ASA

Independent auditor's report

Report on the Audit of the Financial Statements

Opinion

We have audited the financial statements of Photocure ASA, which comprise:

  • The financial statements of the parent company Photocure ASA (the Company), which comprise the balance sheet as at 31 December 2018, the income statement, statement of changes in equity and cash flow statement for the year then ended, and notes to the financial statements, including a summary of significant accounting policies, and
  • The consolidated financial statements of Photocure ASA and its subsidiaries (the Group), which comprise the balance sheet as at 31 December 2018, the income statement, statement of changes in equity and statement of cash flows for the year then ended, and notes to the financial statements, including a summary of significant accounting policies.

In our opinion:

  • The financial statements are prepared in accordance with the law and regulations.
  • The accompanying financial statements give a true and fair view of the financial position of the Company as at 31 December 2018, and its financial performance and its cash flows for the year then ended in accordance with International Financial Reporting Standards as adopted by the EU.
  • The accompanying consolidated financial statements give a true and fair view of the financial position of the Group as at 31 December 2018, and its financial performance and its cash flows for the year then ended in accordance with International Financial Reporting Standards as adopted by the EU.

Basis for Opinion

We conducted our audit in accordance with laws, regulations, and auditing standards and practices generally accepted in Norway, including International Standards on Auditing (ISAs). Our responsibilities under those standards are further described in the Auditor's Responsibilities for the Audit of the Financial Statements section of our report. We are independent of the Company and the Group as required by laws and regulations, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Key Audit Matters

Key audit matters are those matters that, in our professional judgment, were of most significance in our audit of the financial statements of the current period. These matters were addressed in the context of our audit of the financial statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters.

KPMG AS, a Norwegian limited liability company and member firm of the KPMG network of independent member firms affiliated
with KPMG International Cooperative ("KPMG International"), a Swiss entity.

Offices in:

Oslo Elverum Mo i Rana Stord
Alta Finnsnes Molde Straume
Arendal Hamar Skien Tromsø
Bergen Haugesund Sandefjord Trondheim
Bodø Knarvik Sandnessjøen Tynset
Drammen Kristiansand Stavanger Ålesund

Statsautoriserte revisorer - medlemmer av Den norske Revisorforening

1. Deferred tax asset

Refer to Note 12 Tax in the financial statements

The Key Audit Matter How the matter was addressed in our audit
The Group has recognized a deferred tax asset
of NOK 52 million in the Company and Group's
financial statements as of 31 December 2018.
The recognized deferred tax asset relates to
deductible temporary differences and unused
tax losses in the Company in Norway.
Management has assessed that there is
convincing evidence that it is probable that
taxable profits from the product Cysview ®, will
be available in the future, against which unused
tax losses in Norway can be utilized.
Due to the application of the profit/loss split
method for the business in the US, future
taxable profits in Norway are not only
dependent on the development in Europe, but
also the market development for Cysview ® in
the US.
We have determined this to be a key audit
matter, due to the inherent uncertainty in
forecasting the amount of future taxable
profits.
Our audit procedures included, among others:

Comparing historical cash flow
development in mature markets
with expected future cash flows in
new markets for Cysview ®

Evaluating the appropriateness of
key assumptions in the estimated
future taxable profit analysis
prepared by management,
including profit and cash flow
growth, the impact of the expiry of
patents and the reversal of
significant temporary differences

Comparing financial performance
with the original forecasts, to
evaluate the reliability of
management's prognoses related
to future taxable profit

Evaluating management's
sensitivity analysis to assess the
impact of reasonable changes in
key assumptions including future
sales in the US for Cysview ®

Evaluating the adequacy of the
financial statement disclosures in
the financial statements.
From the evidence obtained, we consider
management's assessment of the value of the
deferred tax assets to be acceptable.

Photocure ASA

2. Carrying value of intangible assets

Refer to Note 14 Intangible assets, machinery and equipment in the financial statements

The Key Audit Matter How the matter was addressed in our audit
Our audit procedures with regards to the
The Group has recognized intangible assets of identification of impairment indicators
NOK 23 million in Company and Group's included, among others:
financial statements as of 31 December 2018.
Development costs have been recognized in the
Applying our own knowledge of the
statement of financial position after national business and the industry to challenge
marketing approval has been obtained and management in the identification of any
market launch is completed to the extent this indicators of impairments of intangible
involves significant changes to the product, assets.
physical or the label, which is considered likely
to generate future financial benefits.

Analyzing documentation that the post
marketing clinical trial for Cysview ® has
Due to the size of the balance and the inherent been finalized in accordance with the
judgment in determining the carrying value of project plan and with the expected
intangible assets, we have considered risk of results.
impairment to be a key audit matter. If
Evaluating the adequacy of the financial
management identifies indicators, an statement disclosures in the Company
impairment test is performed. Management did and Group's financial statements.
not identify any impairment indicators. From the evidence obtained, we consider
management's assessment that there are
currently no impairment indicators present,
acceptable.

Photocure ASA

3. Loan to Group company

Refer to Note 25 Related Parties – Companies in the financial statements

The Key Audit Matter How the matter was addressed in our audit
Our audit procedures in this area included,
Photocure ASA has one subsidiary, Photocure among others:
Inc, that was established in order to carry out
Challenging management and applying
the marketing-, selling- and distribution our own knowledge of the business and
activities for the Cysview ® product in the US. the industry to identify any indicators of
Photocure ASA has a long-term loan to impairment of the loan
Photocure Inc. that is recognized at NOK 267
million in the Company's financial statement as

Assessing the impairment
of 31 December 2018. documentation prepared by
management
We have determined risk of impairment of the
Evaluating the appropriateness of key
loan to be a key audit matter, due to the assumptions in the impairment
inherent uncertainty in Photocure Inc. and the documentation, including profit and
Group's ability to successfully commercialize cash flow growth, the impact of the
the individual product concerned. expiry of patents, discount rate and
agree these with the relevant key
assumptions used in valuation of
deferred tax asset

Comparing historical cash flow
development in mature markets in
Europe with expected future cash flows
in the US market

Evaluating management's sensitivity
analysis to assess the impact of
reasonable changes in key assumptions
like future sales in the US for Cysview ®
Evaluating the adequacy of the financial
statement disclosures in the Company's
financial statement
From the evidence obtained, we consider
management's assessment of the carrying value
of the loan to Photocure Inc. to be acceptable.

Other information

Management is responsible for the other information. The other information comprises information in the annual report, except the financial statements and our auditor's report thereon.

Our opinion on the financial statements does not cover the other information and we do not express any form of assurance conclusion thereon.

In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated.

If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact. We have nothing to report in this regard.

Responsibilities of the Board of Directors and the Managing Director for the Financial Statements

The Board of Directors and the Managing Director (Management) are responsible for the preparation in accordance with law and regulations, including fair presentation of the financial statements in accordance with International Financial Reporting Standards as adopted by the EU, and for such internal control as management determines is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, management is responsible for assessing the Company's and the Group's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless management either intends to liquidate the Group or to cease operations, or has no realistic alternative but to do so.

Auditor's Responsibilities for the Audit of the Financial Statements

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with laws, regulations, and auditing standards and practices generally accepted in Norway, including ISAs will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

As part of an audit in accordance with laws, regulations, and auditing standards and practices generally accepted in Norway, including ISAs, we exercise professional judgment and maintain professional scepticism throughout the audit. We also:

  • identify and assess the risks of material misstatement of the financial statements, whether due to fraud or error. We design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control.
  • obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company's or the Group's internal control.
  • evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by management.
  • conclude on the appropriateness of management's use of the going concern basis of accounting and, based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Company and the Group's ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor's report to the related disclosures in the financial statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor's report. However, future events or conditions may cause the Company and the Group to cease to continue as a going concern.
  • evaluate the overall presentation, structure and content of the financial statements, including the disclosures, and whether the financial statements represent the underlying transactions and events in a manner that achieves fair presentation.
  • obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Group to express an opinion on the consolidated financial statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion.

We communicate with the Board of Directors regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit.

We also provide the Board of Directors with a statement that we have complied with relevant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and where applicable, related safeguards.

From the matters communicated with the Board of Directors, we determine those matters that were of most significance in the audit of the financial statements of the current period and are therefore the key audit matters. We describe these matters in our auditor's report unless law or regulation precludes public disclosure about the matter or when, in extremely rare circumstances, we determine that a matter should not be communicated in our report because the adverse consequences of doing so would reasonably be expected to outweigh the public interest benefits of such communication.

Report on Other Legal and Regulatory Requirements

Opinion on the Board of Directors' report

Based on our audit of the financial statements as described above, it is our opinion that the information presented in the Board of Directors' report and in the statements on Corporate Governance and Corporate Social Responsibility concerning the financial statements, the going concern assumption and the proposed allocation of the result is consistent with the financial statements and complies with the law and regulations.

Opinion on Registration and Documentation

Based on our audit of the financial statements as described above, and control procedures we have considered necessary in accordance with the International Standard on Assurance Engagements (ISAE) 3000, Assurance Engagements Other than Audits or Reviews of Historical Financial Information, it is our opinion that management has fulfilled its duty to produce a proper and clearly set out registration and documentation of the Company's accounting information in accordance with the law and bookkeeping standards and practices generally accepted in Norway.

Oslo, 16 April 2019 KPMG AS

Geir Moen State Authorised Public Accountant

Alternative Performance Measures

(Information provided based on Guidelines on Alternative Performance Measures (APMs) for listed issuers by The European Securities and Markets Authority - ESMA)

Photocure reports certain performance measures that are not defined under IFRS but which represent additional measures used by the Board and management in assessing performance as well as for reporting both internally and to shareholders. Photocure believes that the presentation of these non-IFRS performance measures provides useful information which provides readers with a more meaningful understanding of the underlying financial and operating performance of the Company when viewed in conjunction with our IFRS financial information.

Photocure uses the following alternative performance measures.

EBITDA and EBIT

We regard EBITDA as the best approximation to pre-tax operating cash flow and reflects cash generation before working capital changes and capex. EBITDA is widely used by investors when evaluating and comparing businesses, and provides an analysis of the operating results excluding depreciation and amortisation. The non-cash elements depreciation and amortization may vary significantly between companies depending on the value and type of assets.

The definition of EBITDA is "Earnings Before Interest, Tax, Depreciation and Amortization".

The reconciliation to the IFRS accounts is as follows:

All amounts in NOK 1,000 2018 2017
1.1-31.12 1.1-31.12
Gross profit 164,363 138,900
Operating expenses excl amortization & depreciation -174,855 -168,016
EBITDA before restructuring -10,492 -29,116
Amortization & depreciation -13,211 -12,108
EBIT before restructuring -23,703 -41,224

Recurring EBITDA equals EBITDA before restructuring. In 2017 Photocure identified the write-off of parts and finished goods inventory for Nedax as an infrequent and unusual, in total NOK 4.0 million. In 2018 Photocure incurred NOK 14.2 million in restructuring costs. Photocure choose to measure before restructuring and before infrequent and unusual because adjustments of these items give a better basis for an evaluation of future results.

Revenue growth in constant currency

Photocure's business is conducted internationally and in respective local currency. Less than 10% of the revenue is conducted in Norwegian kroner, our reporting currency. Fluctuations in foreign exchange rates may have a significant impact on reported revenue in Norwegian kroner. To eliminate the translational effect of foreign exchange and to better understand the revenue development in the various regions Photocure provides calculated revenue growth information by region and total for the Company.

The average exchange rates used to translate revenues as per the reporting dates were as follows:

2018 2017
1.1-31.12 1.1-31.12
USD (NOK per 1 USD) 8,13 8,27
EUR (NOK per 1 EUR) 9,60 9,33
DKK (NOK per 100 DKK) 128,80 125,42
SEK (NOK per 100 SEK) 93,63 96,80

Alternative Performance Measures

In-market sales

A significant share of Photocure's sales of Hexvix/Cysview, i.e. all sales classified as partner sales and all sales in the Nordic region, goes through partners and distributors. These partners and distributors carry inventory of Hexvix/Cysview. Photocure's billing and revenue therefore does not necessarily reflect the demand from end users / hospitals at a given point in time as inventory levels may vary over time.

Furthermore, Photocure's revenue does not reflect the full value of the product in the market, as partners pay a royalty or a purchase price for the product below the price charged the end user.

To capture end user demand the Company's partners and distributors report their revenue to end users in terms of number of units invoiced and in terms of revenue achieved. Photocure collects this data and consolidate to get the group total in-market sales, in units and in Norwegian kroner.

All amounts in NOK 1,000 2018 2017
1.1-31.12 1.1-31.12
In-market sales 284,809 256,426

Photocure ASA

| Hoffsveien 4 | 0275 Oslo, Norway | +47 22 06 22 10 | [email protected]

Photocure INC

| 104 Carnegie Center, suite 303 | Princeton, NJ 08540 USA | +1609 7596500 | [email protected]

www.photocure.com

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