PFIZER INC — Director's Dealing 2003

Dec 19, 2003

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ARQULE INC (ARQL)
CIK: 0001019695
Period of Report: 2003-12-17

Reporting Person: PFIZER INC (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2003-12-17	Common stock	J	645162	$2.67	Acquired	3273679	Indirect

Footnotes

F1: Shares acquired directly from ArQule as an additional equity investment.

F2: Joint Filer Information
Name: Pfizer Holdings Europe
Address: La Touche House - International Financial Services Centre - Dublin 1, Ireland
Designated Filer: Pfizer Inc.
Issuer and Ticker Symbol: ArQule, Inc. (ARQL)
Date of Event Requiring Statement: December 17, 2003.
Signature: Pfizer Holdings Europe

Signature of Reporting Person: /s/ Brian G. Byala, Director
Date: December 17, 2003