PERCHERON THERAPEUTICS LIMITED — Director's Dealing 2002

Dec 10, 2002

11 December 2002

The Companies Section The Australian Stock Exchange Limited 530 Collins Street MELBOURNE VIC 3000

VIA FACSIMILE NO. 1300 300 021

No of Pages: 3

Dear Sir/Madam

Re: Appendix 3Y - Change of Director's Interest Notice

Please find enclosed a Change of Director's Interest Notice in respect of Mr Mark Diamond.

Yours sincerely

N. Horcher

Natalie Korchev Company Secretary

$[388.11]$ dec $[02.6]$ se]

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

Name of entity:	Antisense Therapeutics Limited
ABN:	41 095 060 745

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	______Mark Diamond
Date of last notice	4 January 2002

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	Mark Diamond is the managing director ofAntisense Therapeutics Limited
Date of change	9 December 2002
No. of securities held prior to change	ordinary shares fully paid150,000options expiring 1/2/0775,000exercisable at 20 cents eachrestricted options expiring3,000,00031/7/05 exercisable at 20 centseach
Class	Fully paid ordinary shares
Number acquired	26,666
Number disposed
Value/ConsiderationNote: If consideration is non-cash, provide details and estimated valuation	$$2,000$ (i.e. 7.5 cents per share)

Appendix 3Y Page 1

+ See chapter 19 for defined terms.

No. of securities held after change	ordinary shares fully paid176,666
	options expiring 1/2/0775,000
	exercisable at 20 cents each
	restricted options expiring3,000,000
	31/7/05 exercisable at 20 cents
	each
Nature of change	Acquisition of ordinary shares under the
Example: on-market trade, off-market trade, exercise of options, issue ofsecurities under dividend reinvestment plan, participation in buy-back-	company's offer information statement.

Part 2 - Change of director's interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosedin this part,

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder(if issued securities)	N/A
Date of change	N/A
No. and class of securities towhich interest related prior tochangeNote: Details are only required for a contract in relationto which the interest has changed	N/A
Interest acquired	N/A
Interest disposed	N/A
Value/ConsiderationNote: If consideration is non-cash, provide details and anestimated valuation	N/A
Interest after change	N/A

+ See chapter 19 for defined terms.