PepGen Inc. — Director's Dealing 2025

Sep 30, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: PepGen Inc. (PEPG)
CIK: 0001835597
Period of Report: 2025-09-26

Reporting Person: RA CAPITAL MANAGEMENT, L.P. (N/A)
Reporting Person: RA Capital Healthcare Fund LP (Director, 10% Owner)
Reporting Person: RA Capital Nexus Fund II, L.P. (Director)
Reporting Person: Kolchinsky Peter (Director, 10% Owner)
Reporting Person: Shah Rajeev M. (Director, 10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-09-26	Common Stock	P	9375000	$3.20	Acquired	18554273	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1302600	Indirect
Common Stock	207672	Indirect

Footnotes

F1: These securities are held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F2: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

F3: These securities are held directly by the Nexus Fund II.

F4: These securities are held directly by the Account.