ORASURE TECHNOLOGIES INC — Major Shareholding Notification 2010

Feb 16, 2010

SC 13G/A 1 v174115_sc13ga.htm Unassociated Document Licensed to: Vintage Filings Document Created using EDGARizer 4.0.6.4 Copyright 1995 - 2008 EDGARfilings, Ltd., an IEC company. All rights reserved

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Amendment No. 2)

Under the Securities Exchange Act of 1934

OraSure Technologies, Inc.

(Name of Issuer)

Common Stock, $0.000001 par value

(Title of Class of Securities)

68554V108

(CUSIP Number)

December 31, 2009

(Date of Event Which Requires Filing of this Statement)

Check the following box to designate the rule pursuant to which the Schedule is filed:

| o | Rule 13d-1(b) | | --- | --- | | x | Rule 13d-1(c) | | o | Rule 13d-1(d) |

• The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

| CUSIP No. 68554V108 — 1. | Names of Reporting Persons I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw Valence Portfolios, L.L.C. 13-4046559 | | | --- | --- | --- | | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | | | | (a) | o | | | (b) | o | | 3. | SEC Use Only | | | 4. | Citizenship or Place of Organization Delaware | |

Number of Shares Beneficially Owned by Each Reporting Person With		Sole Voting Power -0-
	6.	Shared Voting Power -0-
	7.	Sole Dispositive Power -0-
	8.	Shared Dispositive Power -0-
9.	Aggregate Amount Beneficially
Owned by Each Reporting Person -0-
10.	Check if the Aggregate Amount
in Row (9) Excludes Certain Shares (See Instructions) o
11.	Percent of Class Represented by
Amount in Row (9) 0.0%
12.	Type of Reporting Person (See
Instructions) OO

| CUSIP No. 68554V108 — 1. | Names of Reporting Persons I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw & Co., L.P. 13-3695715 | | | --- | --- | --- | | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | | | | (a) | o | | | (b) | o | | 3. | SEC Use Only | | | 4. | Citizenship or Place of Organization Delaware | | | Number of Shares Beneficially Owned by Each Reporting Person With | 5. | Sole Voting Power -0- | | | 6. | Shared Voting Power 293 | | | 7. | Sole Dispositive Power -0- | | | 8. | Shared Dispositive Power 293 | | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 293 | | | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o | | | 11. | Percent of Class Represented by Amount in Row (9) 0.0% | | | 12. | Type of Reporting Person (See Instructions) IA, PN | |

| CUSIP No. 68554V108 — 1. | Names of Reporting Persons I.R.S. Identification Nos. of above persons (entities only) David E. Shaw | | | --- | --- | --- | | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | | | | (a) | o | | | (b) | o | | 3. | SEC Use Only | | | 4. | Citizenship or Place of Organization United States | |

Number of Shares Beneficially Owned by Each Reporting Person With	Sole Voting Power -0-
6.	Shared Voting Power 293
7.	Sole Dispositive Power -0-
8.	Shared Dispositive Power 293

| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person 293 | | --- | --- | | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o | | 11. | Percent of Class Represented by Amount in Row (9) 0.0% | | 12. | Type of Reporting Person (See Instructions) IN |

Item 1.
(a)	Name of Issuer:
	OraSure
Technologies,
Inc.
(b)	Address of Issuer's Principal
Executive Offices:
	220
East First Street Bethlehem,
Pennsylvania
18015
Item 2.
(a)	Name of Person Filing:
	D.
E. Shaw Valence Portfolios, L.L.C. D.
E. Shaw & Co., L.P. David
E. Shaw
(b)	Address of Principal Business
Office or, if none, Residence:
	The
business address for each reporting person is: 120
W. 45 th Street, Tower 45, 39 th Floor New
York, NY 10036
(c)	Citizenship:
	D.
E. Shaw Valence Portfolios, L.L.C. is a limited liability company
organized under the laws of the state of Delaware. D.
E. Shaw & Co., L.P. is a limited partnership organized under the laws
of the state of Delaware. David
E. Shaw is a citizen of the United States of
America.
(d)	Title of Class of Securities:
	Common
Stock, $0.000001 par
value
(e)	CUSIP Number:
	68554V108

Item 3.
Not
Applicable

Item 4.
As
of December 31, 2009: (a)
Amount beneficially owned:

| D.

E. Shaw Valence Portfolios, L.L.C.:	-0- shares
D.
E. Shaw & Co., L.P.:	293
shares This
is composed of 293 shares in the name of D. E. Shaw Synoptic
Portfolios 2,
L.L.C.

David E. Shaw: 293 shares This is composed of 293 shares in the name of D. E. Shaw Synoptic Portfolios 2, L.L.C.

(b) Percent of class:

| D.

E. Shaw Valence Portfolios, L.L.C.:	0.0%
D.
E. Shaw & Co., L.P.:	0.0%
David
E. Shaw:	0.0%

(c) Number of shares to which the person has:

(i) Sole power to vote or to direct the vote:

| D. E. Shaw Valence Portfolios, L.L.C.: | -0- shares | | --- | --- | | D. E. Shaw & Co., L.P.: | -0- shares | | David E. Shaw: | -0- shares |

(ii) Shared power to vote or to direct the vote:

| D. E. Shaw Valence Portfolios, L.L.C.: | -0- shares | | --- | --- | | D. E. Shaw & Co., L.P.: | 293 shares | | David E. Shaw: | 293 shares |

(iii) Sole power to dispose or to direct the disposition of:

| D. E. Shaw Valence Portfolios, L.L.C.: | -0- shares | | --- | --- | | D. E. Shaw & Co., L.P.: | -0- shares | | David E. Shaw: | -0- shares |

(iv) Shared power to dispose or to direct the disposition of:

| D. E. Shaw Valence Portfolios, L.L.C.: | -0- shares | | --- | --- | | D. E. Shaw & Co., L.P.: | 293 shares | | David E. Shaw: | 293 shares |

David E. Shaw does not own any shares directly. By virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Synoptic Portfolios 2, L.L.C., and by virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the managing member of D. E. Shaw Synoptic Portfolios 2, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 293 shares as described above constituting 0.0% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 293 shares.

| Item 5. | Ownership of Five Percent or Less of a Class | | --- | --- | | If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following [X]. | | | Item 6. | Ownership of More than Five Percent on Behalf of Another Person | | Not Applicable | | | Item 7. | Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person | | Not Applicable | | | Item 8. | Identification and Classification of Members of the Group | | Not Applicable | | | Item 9. | Notice of Dissolution of Group | | Not Applicable | | | Item 10. | Certification | | By signing below, each of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw & Co., L.P., and David E. Shaw certify that, to the best of such reporting person’s knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect. | |

SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. A Power of Attorney, dated October 24, 2007, granted by David E. Shaw in favor of Rochelle Elias, is attached hereto.

Dated: February 16, 2010

| D.

E. Shaw Valence Portfolios, L.L.C.
By:	/s/ Rochelle
Elias
	Rochelle
Elias Authorized
Signatory

| D. E. Shaw &

Co., L.P.
By:	/s/ Rochelle
Elias
	Rochelle
Elias Chief
Compliance Officer

| David E.

Shaw
By:	/s/ Rochelle
Elias
	Rochelle
Elias Attorney-in-Fact
for David E.
Shaw