ORASURE TECHNOLOGIES INC — Director's Dealing 2012

May 19, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ORASURE TECHNOLOGIES INC (OSUR)
CIK: 0001116463
Period of Report: 2012-05-16

Reporting Person: Michels Douglas A (Director, President & CEO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-16	Common stock	M	47782	$7.765	Acquired	629211	Direct
2012-05-16	Common stock	S	47782	$12.082	Disposed	581429	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-05-16	Nonqualified stock option	$7.765	M	47782	Disposed	2014-06-22	Common stock (47782)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common stock	5400	Indirect

Footnotes

F1: Sale pursuant to a predetermined sales plan, entered into on February 28, 2012, under Rule 10b5-1 of the Securities and Exchange Act of 1934.

F2: Nonqualified stock options granted on June 22, 2004, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.