ORASURE TECHNOLOGIES INC — Director's Dealing 2011

May 11, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ORASURE TECHNOLOGIES INC (OSUR)
CIK: 0001116463
Period of Report: 2011-05-09

Reporting Person: JERRETT JACK E (Snr. VP & General Counsel)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-09	Common Stock	S	30609	$8.157	Disposed	50310	Direct
2011-05-10	Common Stock	S	22731	$8.012	Disposed	27579	Direct
2011-05-10	Common Stock	M	30000	$5.865	Acquired	57579	Direct
2011-05-10	Common Stock	S	30000	$7.979	Disposed	27579	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-10	Incentive Stock Options	$5.865	M	8258	Disposed	2012-01-31	Common Stock (8258)	Direct
2011-05-10	NonQual. Stock Options	$5.865	M	21742	Disposed	2012-01-31	Common Stock (21742)	Direct

Footnotes

F1: Incentive stock options granted on January 31, 2002, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.

F2: Nonqualified stock options granted on January 31, 2002, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.