ORASURE TECHNOLOGIES INC — Director's Dealing 2011

May 11, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ORASURE TECHNOLOGIES INC (OSUR)
CIK: 0001116463
Period of Report: 2011-05-09

Reporting Person: KUNA MARK L (SVP. VP & Controller)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-09	Common Stock	S	35000	$8.077	Disposed	62463	Direct
2011-05-09	Common Stock	M	15000	$5.865	Acquired	77463	Direct
2011-05-09	Common Stock	M	2874	$6.955	Acquired	80337	Direct
2011-05-09	Common Stock	S	17874	$8.077	Disposed	62463	Direct
2011-05-10	Common Stock	M	7100	$6.955	Acquired	69563	Direct
2011-05-10	Common Stock	S	7100	$8.014	Disposed	62463	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-09	Incentive Stock Options	$5.865	M	11195	Disposed	2012-01-31	Common Stock (11195)	Direct
2011-05-09	NonQual. Stock Options	$5.865	M	3805	Disposed	2012-01-31	Common Stock (3805)	Direct
2011-05-09	NonQual. Stock Options	$6.955	M	2874	Disposed	2013-01-31	Common Stock (2874)	Direct
2011-05-10	NonQual. Stock Options	$6.955	M	7100	Disposed	2013-01-31	Common Stock (7100)	Direct

Footnotes

F1: Incentive stock options granted on January 31, 2002, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.

F2: Nonqualified stock options granted on January 31, 2002, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.

F3: Nonqualified stock options granted on January 31, 2003, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.