ORASURE TECHNOLOGIES INC — Director's Dealing 2011

May 19, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ORASURE TECHNOLOGIES INC (OSUR)
CIK: 0001116463
Period of Report: 2011-05-16

Reporting Person: Lee Stephen R (Exec. VP & CSO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-16	Common Stock	M	19716	$2.805	Acquired	181922	Direct
2011-05-16	Common Stock	S	19716	$7.216	Disposed	162206	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-16	NonQual. Stock Options	$2.805	M	19716	Disposed	2019-01-23	Common Stock (19716)	Direct

Footnotes

F1: Nonqualified stock options, granted on January 23, 2009, vesting and exercisable over a four year period, with one-fourth of the options vesting on the first anniversary date of the grant and the remainder vesting ratably on a monthly basis, over the remaining 36 months.