ORASURE TECHNOLOGIES INC — Director's Dealing 2011

May 24, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ORASURE TECHNOLOGIES INC (OSUR)
CIK: 0001116463
Period of Report: 2011-05-20

Reporting Person: LANCASTER RONNY B (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-20	Common Stock	M	40000	$6.43	Acquired	97715	Direct
2011-05-20	Common Stock	M	20000	$5.598	Acquired	117715	Direct
2011-05-20	Common Stock	S	60000	$7.629	Disposed	57715	Direct
2011-05-23	Common Stock	S	42715	$7.684	Disposed	15000	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-20	NonQual. Stock Options	$6.43	M	40000	Disposed	2013-05-13	Common Stock (40000)	Direct
2011-05-20	NonQual. Stock Options	$5.598	M	20000	Disposed	2015-01-26	Common Stock (20000)	Direct

Footnotes

F1: Nonqualified stock options, granted on May 13, 2003, vesting and exercisable ratably, on a monthly basis, over the subsequent twenty-four months.

F2: Nonqualified stock options, granted on January 26, 2005, vesting and exercisable ratably, on a monthly basis, over the subsequent twelve months.