Opthea Ltd — Share Issue/Capital Change 2021

Mar 24, 2021

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25 March 2021

The Manager Market Announcements Office ASX Limited Level 4, North Tower, Rialto 525 Collins Street MELBOURNE VIC 3000

Dear Sir/Madam

Appendix 2A

We refer to our Appendix 2A dated 25 March 2021. For completeness, the estimated consideration in respect of the 4,147,136 shares referred to in question 4.2d is $26.00 in total (i.e. approximately $0.00000627 per share).

Yours sincerely,

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Mike Tonroe

This announcement was authorised to be given to the ASX by the Company Secretary.

Opthea Limited, Suite 0403, Level 4, 650 Chapel Street, South Yarra, Victoria 3141, Australia A.C.N. 006 340 567 l Telephone: +61 3 9826 0399 l Website: www.opthea.com