Opthea Ltd — Share Issue/Capital Change 2021

Dec 13, 2021

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14 December 2021

The Manager Market Announcements Office ASX Limited Level 4, North Tower, Rialto 525 Collins Street MELBOURNE VIC 3000

Dear Sir/Madam

Notice under section 708A(5)(e) of the Corporations Act 2001 (Cth)

This notice is given by Opthea Limited ACN 006 340 567 (ASX Code: OPT) ( Opthea ) under section 708A(5)(e) of the Corporations Act 2001 (Cth) ( Corporations Act ).

Opthea has today issued 750,000 fully paid ordinary shares in Opthea ( Shares ) in accordance with the announcements made by Opthea on 27 October 2021.

Opthea advises as follows:

• (a) the Shares have been issued without disclosure under Part 6D.2 of the Corporations Act;

• (b) as at the date of this notice, Opthea has complied with:

• (i) the provisions of Chapter 2M of the Corporations Act as they apply to Opthea; and

• (ii) section 674 of the Corporations Act; and

• (c) as at the date of this notice, there is no “excluded information” of the type referred to in sections 708A(7) and 708A(8) of the Corporations Act.

Yours sincerely,

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Karen Adams

This announcement was authorised to be given to the ASX by the Company Secretary.

Opthea Limited, Suite 0403, Level 4, 650 Chapel Street, South Yarra, Victoria 3141, Australia A.C.N. 006 340 567 l Telephone: +61 3 9826 0399 l Website: www.opthea.com