Opthea Ltd — Share Issue/Capital Change 2012

Jun 21, 2012

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22 June 2012

Notice under section 708A(5)(e) of the Corporations Act 2001 (Cth)

Issuer: Circadian Technologies Limited ACN 006 340 567

Details of the issue or offer of securities

Class of securities	Ordinary Shares
ASX Code of the securities	CIR
Date of the issue of the securities	12 June 2012
Total number of securities issued	2,084,714Ordinary Shares

Notice

1. Circadian Technologies Limited gives ASX (as the relevant market operator) notice relating to the issue of securities identified above.

2. This notice is given under paragraph 5(e) of section 708A of the Corporations Act 2001 (Cth).

3. Circadian Technologies Limited issued the securities identified above without disclosure to investors under Part 6D.2 of the Corporations Act 2001 (Cth).

4. As at the date of this notice, Circadian Technologies Limited has complied with:

   • (a) the provisions of Chapter 2M of the Corporations Act 2001 (Cth) as they apply to it; and

   • (b) section 674 of the Corporations Act 2001 (Cth).

5. There is no excluded information (as defined in section 708A(7) of the Corporations Act 2001 (Cth)) as at the date of this notice.

Signed for and on behalf of the Issuer:

Name: Susan Madden Position held: Company Secretary

Level 1 10 Wallace Avenue Toorak Victoria 3142 Australia T +61 (3) 9826 0399 F +61 (3) 9824 0083 www.circadian.com.au

ABN 32 006 340 567