Opthea Ltd — Share Issue/Capital Change 2010

Jul 29, 2010

ASX release

30 July 2010

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Shares to be released from escrow

Circadian Technologies Limited (ASX:CIR) advises that 2,558,716 restricted ordinary shares in Circadian are to be released from escrow on 14 August 2010. These shares are owned by the Ludwig Institute for Cancer Research and Licentia Limited (the commercial arm of the University of Helsinki), the developers of the VEGF technology which is now owned outright by Circadian.

There are now no outstanding restricted Circadian ordinary shares. The company has total issued ordinary shares of 45,241,928.

Susan Madden

Finance Manager & Company Secretary

Level 1/10 Wallace Avenue Toorak 3142 Victoria Australia