Opthea Ltd — Major Shareholding Notification 2023

Jun 1, 2023

Form 605

Corporations Law Section 671B Notice of ceasing to be a substantial holder

To: Company Name/Scheme OPTHEA LIMITED ACN/ARSN 006 340 567

1. Details of substantial holder (1)

Name

UBS Group AG and its related bodies corporate

ACN/ARSN (if applicable):

The holder ceased to be a substantial shareholder on 31 May 2023 The previous notice was given to the company on 17 May 2023 The previous notice was dated 15 May 2023

2. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest (2) of the substantial holder or an associate (3) in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

Date of change	Person whose relevant interest changed	Nature of Change (4)	Consideration given in relation to change (5)	Class (6) and Number of securities affected	Person’s votes affected
Please see Appendix A.

3. Changes in association

The persons who have become associates (3) of, ceased to be associates of, or have changed the nature of their association (7) with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable)	Nature of association
N/A	N/A

4. Addresses

The addresses of persons named in this form are as follows:

Name	Address
N/A	N/A

SIGNATURE

Print Name: Andrew Costley Capacity: Authorised signatory Sign Here: Date: 02 June 2023 Print Name: Florian Naef Capacity: Authorised signatory Sign Here: Date: 02 June 2023

Contact details for this notice:

--------------------------------------------------------------Andrew Costley Group Compliance, Regulatory & Governance (T) + 852 3712 3707

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OPT - Appendix A
Date of Person whose relevant interest changed Nature of Change Consideration given in Number of Class
change relation to change securities
16-May-23 UBS Securities Australia Ltd Sell 192 (283) Ordinary
16-May-23 UBS Securities Australia Ltd Sell 1,180 (1,735) Ordinary
16-May-23 UBS Securities Australia Ltd Sell 1,181 (1,735) Ordinary
16-May-23 UBS Securities Australia Ltd Buy 50,543 74,415 Ordinary
16-May-23 UBS Securities Australia Ltd Sell 39,221 (57,695) Ordinary
16-May-23 UBS Securities Australia Ltd Sell 14,347 (21,009) Ordinary
16-May-23 UBS Securities Australia Ltd Buy 7,303 10,900 Ordinary
16-May-23 UBS Securities Australia Ltd Sell 5,442 (8,066) Ordinary
16-May-23 UBS Securities Australia Ltd Buy 5,714 8,449 Ordinary
16-May-23 UBS Securities Australia Ltd Buy 11,033 16,135 Ordinary
16-May-23 UBS Securities Australia Ltd Sell 327 (480) Ordinary
16-May-23 UBS Securities Australia Ltd Buy 5,616 8,234 Ordinary
16-May-23 UBS Securities Australia Ltd Sell 7,414 (10,960) Ordinary
16-May-23 UBS Securities Australia Ltd Buy 3,589 5,302 Ordinary
16-May-23 UBS Securities Australia Ltd Sell 61 (89) Ordinary
16-May-23 UBS Securities LLC Buy 12 16 ADR
16-May-23 UBS Securities LLC Buy 6 8 ADR
16-May-23 UBS Securities LLC Buy 6 8 ADR
16-May-23 UBS Securities LLC Buy 6 8 ADR
16-May-23 UBS Securities LLC Sell 6 (8) ADR
16-May-23 UBS Securities LLC Buy 6 8 ADR
16-May-23 UBS Securities LLC Buy 6 8 ADR
17-May-23 UBS Securities Australia Ltd Sell 239 (374) Ordinary
17-May-23 UBS Securities Australia Ltd Buy 38,746 59,490 Ordinary
17-May-23 UBS Securities Australia Ltd Sell 42,878 (66,861) Ordinary
17-May-23 UBS Securities Australia Ltd Buy 45,517 69,705 Ordinary
17-May-23 UBS Securities Australia Ltd Sell 21,460 (33,230) Ordinary
17-May-23 UBS Securities Australia Ltd Buy 18,166 28,112 Ordinary
17-May-23 UBS Securities Australia Ltd Sell 23,094 (35,838) Ordinary
17-May-23 UBS Securities Australia Ltd Sell 8,865 (13,596) Ordinary
17-May-23 UBS Securities Australia Ltd Buy 24,141 36,806 Ordinary
17-May-23 UBS Securities Australia Ltd Sell 8,696 (13,480) Ordinary
17-May-23 UBS Securities Australia Ltd Buy 44,027 69,029 Ordinary
17-May-23 UBS Securities Australia Ltd Sell 72 (109) Ordinary
17-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (1,028,588) Ordinary
17-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (1,117,062) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 72 (106) Ordinary
18-May-23 UBS Securities Australia Ltd Buy 1 2 Ordinary
18-May-23 UBS Securities Australia Ltd Sell 1,228 (1,842) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 1,240 (1,842) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 32,543 (48,234) Ordinary
18-May-23 UBS Securities Australia Ltd Buy 46,513 70,357 Ordinary
18-May-23 UBS Securities Australia Ltd Sell 5,955 (8,793) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 1,175 (1,807) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 13,864 (20,711) Ordinary
18-May-23 UBS Securities Australia Ltd Buy 8,832 13,111 Ordinary
18-May-23 UBS Securities Australia Ltd Sell 255 (395) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 1,489 (2,239) Ordinary
18-May-23 UBS Securities Australia Ltd Buy 6,569 9,919 Ordinary
18-May-23 UBS Securities Australia Ltd Sell 4,602 (6,800) Ordinary
18-May-23 UBS Securities Australia Ltd Sell 12,067 (17,730) Ordinary
18-May-23 UBS Securities Australia Ltd Buy 2,027 3,000 Ordinary
18-May-23 UBS Securities Australia Ltd Sell 38 (55) Ordinary
19-May-23 UBS Securities Australia Ltd Buy 9,164 13,366 Ordinary
19-May-23 UBS Securities Australia Ltd Sell 20,550 (29,757) Ordinary
19-May-23 UBS Securities Australia Ltd Sell 147 (216) Ordinary
19-May-23 UBS Securities Australia Ltd Buy 315 463 Ordinary
19-May-23 UBS Securities Australia Ltd Sell 19,184 (27,807) Ordinary
19-May-23 UBS Securities Australia Ltd Sell 9,663 (13,972) Ordinary
19-May-23 UBS Securities Australia Ltd Buy 5,469 7,963 Ordinary
19-May-23 UBS Securities Australia Ltd Sell 245 (352) Ordinary
19-May-23 UBS Securities Australia Ltd Buy 7,742 11,251 Ordinary
19-May-23 UBS Securities Australia Ltd Sell 913 (1,330) Ordinary
19-May-23 UBS Securities Australia Ltd Buy 3,573 5,189 Ordinary
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19-May-23 UBS Securities LLC Sell 229 (320) ADR
22-May-23 UBS Securities Australia Ltd Sell 1,170 (1,755) Ordinary
22-May-23 UBS Securities Australia Ltd Sell 7,602 (11,344) Ordinary
22-May-23 UBS Securities Australia Ltd Buy 5,656 8,482 Ordinary
22-May-23 UBS Securities Australia Ltd Sell 1,509 (2,250) Ordinary
22-May-23 UBS Securities Australia Ltd Buy 2,354 3,510 Ordinary
22-May-23 UBS Securities Australia Ltd Sell 785 (1,180) Ordinary
22-May-23 UBS Securities Australia Ltd Sell 1 (2) Ordinary
22-May-23 UBS Securities Australia Ltd Sell 316 (471) Ordinary
22-May-23 UBS Securities Australia Ltd Buy 866 1,300 Ordinary
23-May-23 UBS Securities Australia Ltd Sell 397 (615) Ordinary
23-May-23 UBS Securities Australia Ltd Sell 1,307 (2,028) Ordinary
23-May-23 UBS Securities Australia Ltd Sell 181 (281) Ordinary
23-May-23 UBS Securities Australia Ltd Buy 20,806 32,307 Ordinary
23-May-23 UBS Securities Australia Ltd Sell 43,124 (66,921) Ordinary
23-May-23 UBS Securities Australia Ltd Sell 24,171 (37,567) Ordinary
23-May-23 UBS Securities Australia Ltd Sell 12,664 (19,537) Ordinary
23-May-23 UBS Securities Australia Ltd Buy 10,324 16,019 Ordinary
23-May-23 UBS Securities Australia Ltd Sell 2,727 (4,235) Ordinary
23-May-23 UBS Securities Australia Ltd Sell 6,094 (9,463) Ordinary
23-May-23 UBS Securities Australia Ltd Buy 14,285 22,275 Ordinary
23-May-23 UBS Securities Australia Ltd Sell 8,186 (12,690) Ordinary
23-May-23 UBS Securities Australia Ltd Buy 5,711 8,852 Ordinary
23-May-23 UBS Securities Australia Ltd Sell 771 (1,200) Ordinary
23-May-23 UBS Securities Australia Ltd Buy 16,225 25,253 Ordinary
23-May-23 UBS Securities Australia Ltd Buy 127 199 Ordinary
23-May-23 UBS Securities LLC Sell 406 (608) ADR
23-May-23 UBS Securities LLC Buy 406 608 ADR
23-May-23 UBS Securities LLC Buy 352 528 ADR
23-May-23 UBS Securities LLC Buy 53 80 ADR
24-May-23 UBS Securities Australia Ltd Buy 934 1,442 Ordinary
24-May-23 UBS Securities Australia Ltd Sell 15,241 (23,652) Ordinary
24-May-23 UBS Securities Australia Ltd Buy 21,943 34,137 Ordinary
24-May-23 UBS Securities Australia Ltd Buy 395 603 Ordinary
24-May-23 UBS Securities Australia Ltd Sell 15,171 (23,506) Ordinary
24-May-23 UBS Securities Australia Ltd Sell 19,023 (29,438) Ordinary
24-May-23 UBS Securities Australia Ltd Sell 1,882 (2,955) Ordinary
24-May-23 UBS Securities Australia Ltd Sell 8,009 (12,419) Ordinary
24-May-23 UBS Securities Australia Ltd Buy 9,604 14,916 Ordinary
24-May-23 UBS Securities Australia Ltd Sell 2,980 (4,657) Ordinary
24-May-23 UBS Securities Australia Ltd Buy 6,211 9,680 Ordinary
24-May-23 UBS Securities Australia Ltd Sell 5,406 (8,441) Ordinary
24-May-23 UBS Securities Australia Ltd Sell 15,800 (24,341) Ordinary
24-May-23 UBS Securities Australia Ltd Buy 6,072 9,521 Ordinary
25-May-23 UBS Securities Australia Ltd Buy 2,923 4,489 Ordinary
25-May-23 UBS Securities Australia Ltd Sell 3,900 (6,000) Ordinary
25-May-23 UBS Securities Australia Ltd Buy 10,039 15,540 Ordinary
25-May-23 UBS Securities Australia Ltd Sell 825 (1,273) Ordinary
25-May-23 UBS Securities Australia Ltd Sell 1,350 (2,086) Ordinary
25-May-23 UBS Securities Australia Ltd Sell 1,755 (2,700) Ordinary
25-May-23 UBS Securities Australia Ltd Sell 707 (1,088) Ordinary
25-May-23 UBS Securities Australia Ltd Buy 1,061 1,640 Ordinary
25-May-23 UBS Securities Australia Ltd Sell 520 (800) Ordinary
25-May-23 UBS Securities Australia Ltd Buy 68 105 Ordinary
25-May-23 UBS Securities Australia Ltd Sell 2,866 (4,409) Ordinary
25-May-23 UBS Securities Australia Ltd Buy 123 190 Ordinary
25-May-23 UBS Securities Australia Ltd Sell 1,617 (2,488) Ordinary
25-May-23 UBS Securities Australia Ltd Buy 97 151 Ordinary
26-May-23 UBS Securities Australia Ltd Sell 6 (10) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 770 1,225 Ordinary
26-May-23 UBS Securities Australia Ltd Sell 1,329 (2,129) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 1,329 (2,129) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 117,268 (185,904) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 43,287 68,884 Ordinary
26-May-23 UBS Securities Australia Ltd Sell 63,200 (100,000) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 69,911 (111,358) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 4,670 7,355 Ordinary
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26-May-23 UBS Securities Australia Ltd Sell 8,422 (13,534) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 17,871 (28,250) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 15,740 25,261 Ordinary
26-May-23 UBS Securities Australia Ltd Sell 1,111 (1,772) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 26,226 (41,537) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 24,656 39,362 Ordinary
26-May-23 UBS Securities Australia Ltd Sell 11,120 (17,861) Ordinary
26-May-23 UBS Securities Australia Ltd Sell 13,358 (21,434) Ordinary
26-May-23 UBS Securities Australia Ltd Buy 17,064 27,190 Ordinary
29-May-23 UBS Securities Australia Ltd Buy 248,000 400,000 Ordinary
29-May-23 UBS Securities Australia Ltd Buy 3 5 Ordinary
29-May-23 UBS Securities Australia Ltd Sell 407 (651) Ordinary
29-May-23 UBS Securities Australia Ltd Sell 1,428 (2,276) Ordinary
29-May-23 UBS Securities Australia Ltd Sell 1,427 (2,276) Ordinary
29-May-23 UBS Securities Australia Ltd Sell 8,009 (12,729) Ordinary
29-May-23 UBS Securities Australia Ltd Buy 32,884 52,297 Ordinary
29-May-23 UBS Securities Australia Ltd Sell 10,528 (16,818) Ordinary
29-May-23 UBS Securities Australia Ltd Sell 1 (1) Ordinary
29-May-23 UBS Securities Australia Ltd Buy 1,440 2,322 Ordinary
29-May-23 UBS Securities Australia Ltd Sell 8,569 (13,601) Ordinary
29-May-23 UBS Securities Australia Ltd Sell 1,923 (3,068) Ordinary
29-May-23 UBS Securities Australia Ltd Buy 3,635 5,771 Ordinary
29-May-23 UBS Securities Australia Ltd Sell 9,183 (14,595) Ordinary
29-May-23 UBS Securities Australia Ltd Buy 669 1,071 Ordinary
29-May-23 UBS Securities Australia Ltd Sell 8,766 (13,872) Ordinary
29-May-23 UBS Securities Australia Ltd Buy 3,145 5,027 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 1 (2) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 1,456 (2,332) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 1,456 (2,332) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 137 (221) Ordinary
30-May-23 UBS Securities Australia Ltd Buy 13,372 21,491 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 13,425 (21,353) Ordinary
30-May-23 UBS Securities Australia Ltd Buy 16,629 26,572 Ordinary
30-May-23 UBS Securities Australia Ltd Buy 979 1,579 Ordinary
30-May-23 UBS Securities Australia Ltd Buy 1,311 2,097 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 304 (482) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 753 (1,213) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 1,130 (1,802) Ordinary
30-May-23 UBS Securities Australia Ltd Buy 2,624 4,200 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 804 (1,296) Ordinary
30-May-23 UBS Securities Australia Ltd Buy 16,668 26,482 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 6,855 (11,043) Ordinary
30-May-23 UBS Securities Australia Ltd Sell 10,294 (16,415) Ordinary
30-May-23 UBS Securities Australia Ltd Buy 1,888 3,025 Ordinary
30-May-23 UBS Securities Australia Ltd Sell 6 (9) Ordinary
31-May-23 UBS Securities Australia Ltd Buy 312 521 Ordinary
31-May-23 UBS Securities Australia Ltd Sell 1,393 (2,320) Ordinary
31-May-23 UBS Securities Australia Ltd Sell 1,393 (2,320) Ordinary
31-May-23 UBS Securities Australia Ltd Sell 52,876 (87,124) Ordinary
31-May-23 UBS Securities Australia Ltd Buy 28,127 46,730 Ordinary
31-May-23 UBS Securities Australia Ltd Buy 21,668 35,868 Ordinary
31-May-23 UBS Securities Australia Ltd Buy 2,057 3,400 Ordinary
31-May-23 UBS Securities Australia Ltd Sell 20,558 (33,992) Ordinary
31-May-23 UBS Securities Australia Ltd Sell 10,115 (16,858) Ordinary
31-May-23 UBS Securities Australia Ltd Sell 34,703 (56,928) Ordinary
31-May-23 UBS Securities Australia Ltd Buy 6,566 10,857 Ordinary
31-May-23 UBS Securities Australia Ltd Sell 6,792 (11,265) Ordinary
31-May-23 UBS Securities Australia Ltd Sell 13,735 (22,461) Ordinary
31-May-23 UBS Securities Australia Ltd Buy 4,333 7,173 Ordinary
31-May-23 UBS Securities Australia Ltd Sell 75,067 (123,669) Ordinary
31-May-23 UBS Securities Australia Ltd Buy 4,765 7,921 Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (3,260,210) Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (2,611,256) Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (2,781,139) Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (9,293,828) Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (3,990,858) Ordinary
31-May-23 UBS AG, Australia Branch Return of Rehypothecated positi N/A (936,988) Ordinary
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